Acute Poisoning With Peganum Harmala, Esfand: A Rare Case Report
International Journal of Medical Toxicology and Forensic Medicine,
Vol. 8 No. 3(Summer) (2018),
1 July 2018
,
Page 119-121
https://doi.org/10.22037/ijmtfm.v8i3(Summer).22342
Abstract
Peganum harmala, is a plant of the family Nitrariaceae with small seeds, traditionally used to induce abortion and menstruation. It also has pharmacological properties such as lowering blood glucose, as well as analgesic, anti-cancer, antibacterial and antifungal effects. The current report presents a rare case of a middle-aged female referring to Clinical Toxicology Service with the history of drinking a glass of boiled Esfand seeds, in order to reduce blood sugar, and complaining of nausea, abdominal pain, general weakness, dizziness, and several vomiting episodes.
- Zygophyllaceae
- Harmaline
- Triterpenes
- Poisoning
How to Cite
References
Farouk L, Laroubi A, Aboufatima R, Benharref A, Chait A. Evaluation of the analgesic effect of alkaloid extract of Peganumharmala L.: Possible mechanisms involved. Journal of Ethnopharmacology. 2008; 115(3):449–54. [DOI:10.1016/j.jep.2007.10.014] [PMID]
El-Dwairi QA, Banihani SM. Histo-functional effects of Peganumharmala on male rat’s spermatogenesis and fertility. NeuroEndocrinol. Neuroendocrinology Letters. 2007; 28(3):305-10. [PMID]
Hemmateenejad B, Abbaspour A, Maghami H, Miri R, Panjehshahin MR. Partial least squares-based multivariate spectral calibration method for simultaneous determination of beta-carboline derivatives in Peganum harmala seed extracts. Analytica Chimica Acta. 2006; 575(2):290–9. [DOI:10.1016/j.aca.2006.05.093] [PMID]
Louis ED, Zheng W, Jiang W, Bogen KT, Keating GA. Quantification of the neurotoxic beta-carboline harmane in barbecued/grilled meat samples and correlation with level of doneness. Journal of Toxicology and Environmental Health, Part A. 2007; 70(12):1014–9. [DOI:10.1080/15287390601172015] [PMID] [PMCID]
Rommelspache H, Nanz C, Borbe HO, Fehske KJ, Müller WE, Wollert U. 1-Methyl-β-carboline (Harmane), a potent endogenous inhibitor of benzodiazepine receptor binding. Naunyn-Schmiedeberg’s Archives of Pharmacology. 1980; 314(1):97-100. [DOI:10.1007/BF00498436] [PMID]
Louis ED, Zheng W, Jurewicz EC, Watner D, Chen J, Factor Litvak P, et al. Elevation of blood β-carboline alkaloids in essential tremor. Neurology. 2002; 59(12):1940-4. [DOI:10.1212/01.WNL.0000038385.60538.19] [PMID] [PMCID]
Jahaniani F, Ebrahimi SA, Rahbar Roshandel N, Mahmoudian M. Xanthomicrol is the main cytotoxic component of Dracocephalum Kotschyii and a potential anti-cancer agent. Phytochemistry. 2005; 66(13):1581-92. [DOI:10.1016/j.phytochem.2005.04.035] [PMID]
Yonezawa T, Lee JW, Hibino A, Asai M, Hojo H, Cha BY, et al. Harmine promotes osteoblast differentiation through bone morphogenetic protein signaling. Biochemical and Biophysical Research Communications. 2011; 409(3):260–265. [DOI:10.1016/j.bbrc.2011.05.001] [PMID]
Hara ES, Ono M, Kubota S, Sonoyama W, Oida Y, Hattori T, et al. Novel chondrogenic and chondroprotective effects of the natural compound harmine. Biochimie. 2013; 95(2):374-81. [DOI:10.1016/j.biochi.2012.10.016] [PMID]
Egusa H, Doi M, Saeki M, Fukuyasu S, Akashi Y, Yokota Y, at al. The small molecule harmine regulates NFATc1 and Id2 expression in osteoclast progenitor cells. Bone. 2011; 49(2):264-74. [DOI:10.1016/j.bone.2011.04.003] [PMID]
Zheng XY, Zhang ZJ, Chou GX, Wu T, Cheng XM, Wang CH, et al. Acetylcholinesterase inhibitive activity-guided isolation of two new alkaloids from seeds of peganum nigellastrum bunge by an in vitro TLC-bioautographic assay. Archives of Pharmacological Research. 2009; 32(9):1245-51. [DOI:10.1007/s12272-009-1910-x] [PMID]
Avula B, Begum S, Ahmed S, Choudhary MI, Khan IA. Quantitative determination of vasicine and vasicinone in Adhatoda vasica by high performance capillary electrophoresis. Die Pharmazie- An International Journal of Pharmaceutical Sciences. 2008; 63(1):20-2.
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