Comparison of Diffuse Weighted Imaging and Fluid Attenuation Inversion Recovery Sequences of MRI in Brain Multiple Sclerosis Plaques Detection
Iranian Journal of Child Neurology,
Vol. 11 No. 1 (2017),
1 January 2017
How to Cite This Article: Nafisi-Moghadam R, Rahimdel A, Shanbehzadeh T, Fallah R. Comparison of Diffuse Weighted Imaging and Fluid Attenuation Inversion Recovery Sequences of MRI in Brain Multiple Sclerosis Plaques Detection. Iran J Child Neurol. Winter 2017; 11(1):13-20.
Suitable magnetic resonance imaging (MRI) techniques from conventional to new devices can help physicians in diagnosis and follow up of Multiple Sclerosis (MS) patients. The aim of present research was to compare effectiveness of Fluid Attenuation Inversion Recovery (FLAIR) sequence of conventional MRI and Diffuse Weighted Imaging (DWI) sequence as a new technique in detection of brain MS plaques.
In this analytic cross sectional study, sample size was assessed as 40 people to detect any significant difference between two sequences with a level of 0.05.
DWI and FLAIR sequences of without contrast brain MRI of consecutive MS patients referred to MRI center of Shahid Sadoughi Hospital, Yazd, Iran from January to May 2012, were evaluated.
Thirty-two females and 8 males with mean age of 35.20±9.80 yr (range =11-66 yr) were evaluated and finally 340 plaques including 127(37.2%) in T2WI, 127(37.2%) in FLAIR, 63(18.5%) in DWI and 24(7.1%) in T1WI were detected. FLAIR sequence was more efficient than DWI in detection of brain MS plaques, oval, round, amorphous plaque shapes, frontal and occipital lobes, periventricular, intracapsular, corpus callosum, centrum semiovale, subcortical, basal ganglia plaques and diameter of detected MS plaques in DWI sequence was smaller than in FLAIR.
Old lesion can be detected by conventional MRI and new techniques might be more useful in early inflammatory phase of MS and assessment of experimental treatments.References
1. Inglese M, Bester M. Diffusion imaging in multiple sclerosis: research and clinical implications. NMR
2. Inaloo S, Haghbin S. Multiple Sclerosis in Children. Iran J Child Neurol 2013;7(2):1-10.
3. Polman CH, Reingold SC, Edan G, Filippi M, Hartung HP, Kappos L, et al. Diagnostic criteria for multiple sclerosis: 2005 revisions to the McDonald criteria. Ann Neurol 2005;58(6):840-6.
4. Sahraian MA, Eshaghi A. Role of MRI in diagnosis and treatment of multiple sclerosis. Clin Neurol Neurosurg 2010 ;112(7):609-15.
5. Miller DH; Steering Committee of MAGNIMS. Role of MRI in diagnosing multiple sclerosis: magnetic resonance imaging is valuable. BMJ 2006, 29;332(7548):1034.
6. Rovira A, León A. MR in the diagnosis and monitoring of multiple sclerosis: an overview. Eur J Radiol 2008;67(3):409-14.
7. Bakshi R, Thompson AJ, Rocca MA, Pelletier D, Dousset V, Barkhof F, Inglese M, Guttmann CR, Horsfield MA, Filippi M. MRI in multiple sclerosis: current status and future prospects. Lancet Neurol 2008 ;7(7):615-25.
8. Nielsen JM, Korteweg T, Barkhof F, Uitdehaag BM, Polman CH. Over diagnosis of multiple sclerosis and magnetic resonance imaging criteria. Ann Neurol 2005;58(5):781-3.
9. Zecca C, Cereda C, Wetzel S, Tschuor S, Staedler C, Santini F, Nadarajah N, Bassetti CL, Gobbi C. Diffusion weighted imaging in acute demyelinating myelopathy. Neuroradiology 2012;54(6):573-8.
10. Lo CP, Kao HW, Chen SY, Chu CM, Hsu CC, Chen YC, Lin WC, Liu DW, Hsu WL. Comparison of diffusion weighted imaging and contrast-enhanced T1-weighted imaging on a single baseline MRI for demonstrating dissemination in time in multiple sclerosis. BMC Neurol 2014,7;14:100.
11. Miabi Z, Midia M, Midia R, Moghinan D. Anatomical distribution of central nervous system plaques in multiple sclerosis: an Iranian experience. Pak J Biol Sci 2010;13(24):1195-201
12. Miabi Z, Hashemi H, Moghinan Hokmabad D, Samimi K. Diffusion-weighted and conventinal MRI in detection of multiple sclerosis lesion in brain : a comparative study.Tehran University Medical Journal (TUMJ)
13. Poloni G, Minagar A, Haacke EM, Zivadinov R. Recent developments in imaging of multiple sclerosis. Neurologist 2011;17(4):185-204.
14. Filippi M, Rocca MA. MRI aspects of the “inflammatory phase” of multiple sclerosis. Neurol Sci 2003 ;24 Suppl 5:S275-8.
15. Filippi M, Rocca MA, De Stefano N, Enzinger C, Fisher E, Horsfield MA, Inglese M, Pelletier D, Comi G. Magnetic resonance techniques in multiple sclerosis: the present and the future. Arch Neurol 2011 ;68(12):1514- 20.
16. Bhatt A, Masih A, Grothous HF, Farooq MU, Naravetla B, Kassab MY. Diffusion-weighted imaging: not all that glitters is gold. South Med J 2009 ;102(9):923-8.
17. Wilson M, Morgan PS, Lin X, Turner BP, Blumhardt LD. Quantitative diffusion weighted magnetic resonance imaging, cerebral atrophy, and disability in multiple sclerosis. J Neurol Neurosurg Psychiatry 2001;70(3):318- 22.
18. Cheng GX, Wu HW, Zhang J, Liang LN, Zhang XL. MRI diagnosis of multiple cerebral sclerosis. Nan Fang Yi Ke Da Xue Xue Bao. 2008;28(8):1372-5. [Article in Chinese]
- Multiple Sclerosis
- Magnetic Resonance Imaging
- Diffuse Weighted Imaging
- Fluid Attenuation Inversion Recovery
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