Hyperventilation-Induced High-Amplitude Rhythmic Slowing and Its Impact on Migraine Frequency in Children: A Retrospective Observational Cohort Study Migraine and Hyperventilation-induced high-amplitude rhythmic slowing
Iranian Journal of Child Neurology,
Vol. 20 No. 2 (2026),
1 April 2026
,
Page 39-43
https://doi.org/10.22037/ijcn.v20i2.47514
Abstract
Objectives:
The most common primary headache disorder in children is migraine. Some children with hyperventilation (HV) may exhibit hyperventilation-induced high-amplitude rhythmic slowing (HIHARS) in their electroencephalogram (EEG). The study aims to evaluate the correlation between HIHARS and a child’s future migraine onset risk.
Materials & Methods:
The present study evaluated HIHARS during the HV maneuver in children aged 7 to 12 admitted to the Electroencephalography Monitoring Unit for diverse referral reasons. After six years, the researchers assessed Long-term video-EEG monitoring data for migraine disease according to the International Classification of Headache Disorders, Third Edition (ICHD-3). The clinical and neurophysiological data were analyzed using appropriate statistical methods.
Results:
The study revealed that among children with HIHARS, migraine was higher (P=0.049) after six years. Additionally, 15 children (68.18%) with HIHARS had a family history of migraine, compared to 12 children (40%) without HIHARS, which was significant (P=0.044). Interestingly, no significant difference was observed between patients with seizures and those without (P=0.1), suggesting that seizures do not act as a confounding factor in this study.
Conclusion:
This is the first study on the correlation of HIHARS with migraine in children. Patients aged 7 to 12 years old with HIHARS had more susceptibility to migraine headaches. It is suggested that children with HIHARS and a history of migraine in first-degree family members will be more susceptible to developing migraine in life
- childern
- HIHARS
- Migraine
- EEG
How to Cite
References
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