Serum and Cerebrospinal Fluid Lactate Dehydrogenase in Children with Febrile Convulsions
Iranian Journal of Child Neurology,
Vol. 17 No. 1 (2023),
Tissue damage caused by febrile convulsion has not still been proved or refuted completely. Given the fact that lactate dehydrogenase as an intracellular enzyme can be increased due to tissue damage, we decided to evaluate serum and cerebrospinal fluid lactate dehydrogenase in children with febrile convulsion.
Materials & Methods
This is a cross-sectional study on 166 children aged 6-24 month, in three groups of simple febrile convulsion (n=56), complex febrile convulsion (n=27) with 3 different subgroups (recurrence in 24 hours, duration >15 minutes, and with focal components), and control (n=83). Patients’ serum and cerebrospinal fluid specimens were collected after meeting the inclusion criteria. Demographic information was documented and patients’ serum and cerebrospinal fluid lactate dehydrogenase and glucose were measured. Data were analyzed using SPSS software.
The mean serum lactate dehydrogenase in simple febrile convulsion, complex febrile convulsion, and controls were 501.57± 143.70, 553.07±160.22, and 505.87±98.73 U/L, respectively. The mean cerebrospinal fluid lactate dehydrogenase in simple, complex febrile convulsion, and control groups were 22.58±11.92, 29.48±18.18, and 21.56±17.32 U/L, respectively. Only cerebrospinal fluid lactate dehydrogenase difference between complex febrile convulsion and control group (p=0.039) (In the duration >15 minutes subgroup and controls, p=0.028) was statisticallysignificant. There was a significantThere was a significant difference between sex and serum lactate dehydrogenase in the same subgroup of complex group (p=0.012).
Complex febrile convulsion may lead to increase of lactate dehydrogenase in cns of CNS cellular damage
- Cerebrospinal Fluid; Lactate Dehydrogenase; Convulsions; Febrile; Seizure, Febrile; Complex; Pediatrics
How to Cite
Quvile T, Wilmshurst JM. Febrile Seizures. In Clinical Child Neurology 2020 (pp. 767-776). Springer, Cham.
Thadchanamoorthy V, Dayasiri K. Review on Febrile Seizures in Children. International Neuropsychiatric Disease Journal. 2020 Sep 15:25-35.
Otman MA, Saed MM. Febrile seizures: What do you want to know?. International Journal of Pharmacy & Life Sciences. 2020 Aug 1;11(8).
Kumaresan G. FEBRILE FITS. Indian Journal of Practical Pediatrics. 2020;22(1):5.
Finegersh A, Avedissian C, Shamim S, Dustin I, Thompson PM, Theodore WH. Bilateral hippocampal atrophy in temporal lobe epilepsy: effect of depressive symptoms and febrile seizures. Epilepsia. 2011; 52(4):689-97.
Crespel A, Coubes P, Rousset MC, Brana C, Rougier A, Rondouin G, et al. Inflammatory reactions in human medial temporal lobe epilepsy with hippocampal sclerosis. Brain Res. 2002; 952(2):159-69..
Theodore WH, Bhatia S, Hatta J, Fazilat S, DeCarli C, Bookheimer SY, et al. Hippocampal atrophy, epilepsy duration, and febrile seizures in patients with partial seizures. Neurology. 1999; 52(1):132-6
Cendes F, Andermann F, Dubeau F, Gloor P, Evans A, Jones-Gotman M, et al. Early childhood prolonged febrile convulsions atrophy and sclerosis of mesial structures, and temporal lobe epilepsy: An MRI volumetric study. Neurology. 2011; 76:1845.
Boison D, Steinhäuser C. Epilepsy and astrocyte energy metabolism. Glia. 2018 Jun; 66(6):1235- 43.
Khan AA, Allemailem KS, Alhumaydhi FA, Gowder SJ, Rahmani AH. The biochemical and clinical perspectives of lactate dehydrogenase: an enzyme of active metabolism. Endocrine, Metabolic & Immune Disorders-Drug Targets. 2020 Aug 1; 20(6):855-68.
Jialal I, Sokoll LJ. Clinical utility of lactate
dehydrogenase: a historical perspective. American Journal of Clinical Pathology. 2015 Feb; 143(2):158-9.
Nussinovitch M, Avitzur Y, Finkelstein Y, Amir J, Harel D, Volovitz B. Lactic dehydrogenase isoenzyme in cerebrospinal fluid of children with febrile convulsions. Acta Paediatr. 2003; 92(2):186-9.
Baheerathan A, Pitceathly RD, Curtis C, Davies NW. CSF lactate. Practical neurology. 2020 Aug 1; 20(4):320-3.
Cacho-Díaz B, Lorenzana-Mendoza NA, Reyes-Soto G, Hernández Estrada A, Monroy- Sosa A, Guraieb-Chahin P, Cantu-de-León D. Lactate dehydrogenase as a prognostic marker in neoplastic meningitis. Journal of Clinical Neuroscience. 2018 May 1; 51:39-42.
Ehsanipour F, Mo’adabi H, Shayanfar N. A Comparison of CSF Lactic Dehydrogenase in Children with Simple and Complex Febrile Convulsion. Razi Journal of Medical Sciences. 2008; 15(0):7-12.
Nussinovitch M, Finkelstein Y, Elishkevitz KP, Volovitz B, Harel D, Klinger G, Razon Y, Nussinovitch U, Nussinovitch N. Cerebrospinal fluid lactate dehydrogenase isoenzymes in children with bacterial and aseptic meningitis. Translational Research. 2009 Oct 1; 154(4):214-8.
Whelan H, Harmelink M, Chou E, Sallowm D, Khan N, Patil R, et al. Complex febrile seizures-A systematic review. Dis Mon. 2017; 63(1):5-23.
American Academy of Pediatrics. Provisional Committee on Quality Improvement, Subcommittee on Febrile Seizures. Practice parameter: the neurodiagnostic evaluation of the child with a first simple febrile seizure. Pediatrics. 1996 May; 97(5):769-72.
Joint Working Group of the Research Unit of the Royal College of Physicians and the British Paediatric Association. Guidelines for the management of convulsions with fever. BMJ: British Medical Journal. 1991 Sep 14:634-6.
Bonadio W. Pediatric lumbar puncture and cerebrospinal fluid analysis. J Emerg Med. 2014; 46(1):141-50.
Westin E, Sund Levander M. Parent’s Experiences of Their Children Suffering Febrile Seizures. J Pediatr Nurs. 2018; 38:68-73.
Nelson PV, Carey WF, Pollard AC. Diagnostic significance and source of lactate dehydrogenase and its isoenzymes in cerebrospinal fluid of
children with a variety of neurological disorders. J Clin Pathol. 1975; 28(10):828-33.
Lending M, Slobody LB, Mestern J. Cerebrospinal fluid glutamic oxalacetic transaminase and lactic dehydrogenase activities in children with neurologic disorders. J Pediatr. 1964; 65:415-21.
Jain MK, Shah A, Rao SR, Sheth SS. Cerebrospinal dehydrogenases in central nervous system infections. Indian Pediatr. 1991; 28(4):369-74.
Nussinovitch M, Harel D, Eidlitz-Markus T, Amir J, Volovitz B. Lactic dehydrogenase isoenzyme in cerebrospinal fluid of children with infantile spasms. Eur Neurol. 2003; 49(4):231-3.
Nussinovitch M, Prais D, Finkelstein Y, Harel D, Amir J, Volovitz B. Lactic dehydrogenase isoenzymes in cerebrospinal fluid of children with Guillain Barre syndrome. Arch Dis Child. 2002; 87(3):255-6.
Nussinovitch M, Volovitz B, Finkelstein Y, Amir J, Harel D. Lactic dehydrogenase isoenzymes in cerebrospinal fluid associated with hydrocephalus. Acta Paediatr. 2001; 90(9):972-4.
Parakh N, Gupta HL, Jain A. Evaluation of enzymes in serum and cerebrospinal fluid in cases of stroke. Neurol India. 2002; 50(4):518- 9.
Schmidt H, Otto M, Niedmann P, Cepek L, Schroter A, Kretzschmar HA, et al. CSF lactate dehydrogenase activity in patients with Creutzfeldt-Jakob disease exceeds that in other dementias. Dement Geriatr Cogn Disord. 2004; 17(3):204-6.
- Abstract Viewed: 105 times
- pdf Downloaded: 0 times