• Register
  • Login

Iranian Journal of Child Neurology

  • Home
  • About
    • About the Journal
    • Indexing & Abstracting
    • Submissions
    • Editorial Team
    • Privacy Statement
    • Contact
  • Current
  • Archives
  • Announcements
Advanced Search
  1. Home
  2. Archives
  3. Vol. 17 No. 2 (2023): spring
  4. Case Report

Vol. 17 No. 2 (2023)

March 2023

What kept back on the mirror of COVID-19 related transverse myelitis? A genetic background!

  • Reza Sinaei
  • Sara Pezeshki
  • Roya Sinaei

Iranian Journal of Child Neurology, Vol. 17 No. 2 (2023), 16 March 2023 , Page 143-147
https://doi.org/10.22037/ijcn.v17i2.36487 Published: 2023-03-15

  • View Article
  • Download
  • Cite
  • References
  • Statastics
  • Share

Abstract

 

The acute transverse myelitis associated with COVID-19 cases have been reported worldwide. Nevertheless, Iran, Italy and USA are the most affected countries, witnessing the possibility that genetic factors might be associated with this susceptibility. The genetic variants of the coronavirus-2 entry mechanisms and host innate immune response related genes like interferons, interleukins, Toll-like receptors, human leukocyte antigen, blood groups, and some risk loci may be accountable. Here, we have a description of the compatibility of the geographical distribution between ATM and the Neanderthal core haplotype that confers risk for severe COVID-19, as well as some possible culprit genes.

Keywords:
  • COVID-19
  • transverse myelitis
  • genetic
  • pdf

How to Cite

Sinaei, R., Pezeshki, S. ., & Sinaei, R. . (2023). What kept back on the mirror of COVID-19 related transverse myelitis? A genetic background!. Iranian Journal of Child Neurology, 17(2), 143–147. https://doi.org/10.22037/ijcn.v17i2.36487
  • ACM
  • ACS
  • APA
  • ABNT
  • Chicago
  • Harvard
  • IEEE
  • MLA
  • Turabian
  • Vancouver
  • Endnote/Zotero/Mendeley (RIS)
  • BibTeX

References

Biglari HN, Sinaei R, Pezeshki S, Hasani FK. Acute transverse myelitis of childhood due to novel coronavirus disease 2019: The first pediatric case report and review of literature. Iranian Journal of Child Neurology. 2021;15(1):107.

Zeberg H, Pääbo S. The major genetic risk factor for severe COVID-19 is inherited from Neanderthals. Nature. 2020;587(7835):610-2. Doi:https://doi.org/10.1038/s41586-020-2818-3

Clohisey S, Baillie JK. Host susceptibility to severe influenza A virus infection. Critical Care. 2019;23(1):1-10. Doi:https://doi.org/10.1186/s13054-019-2566-7

Pairo-Castineira E, Clohisey S, Klaric L, et al. Genetic mechanisms of critical illness in Covid-19. Nature. 2021;591(7848):92-8. Doi:https://doi.org/10.1038/s41586-020-03065-y

Group SC-G. Genomewide association study of severe Covid-19 with respiratory failure. New England Journal of Medicine. 2020;383(16):1522-34. Doi:10.1056/NEJMoa2020283

Zeberg H, Pääbo S. A genomic region associated with protection against severe COVID-19 is inherited from Neandertals. Proceedings of the National Academy of Sciences. 2021;118(9). Doi:https://doi.org/10.1073/pnas.2026309118

Yildirim Z, Sahin OS, Yazar S, Bozok Cetintas V. Genetic and epigenetic factors associated with increased severity of Covid‐19. Cell biology international. 2021;45(6):1158-74. Doi: https://doi.org/10.1002/cbin.11572

Wang F, Huang S, Gao R, et al. Initial whole-genome sequencing and analysis of the host genetic contribution to COVID-19 severity and susceptibility. Cell discovery. 2020;6(1):1-16. Doi:https://doi.org/10.1038/s41421-020-00231-4

Román GC, Gracia F, Torres A, Palacios A, Gracia K, Harris D. Acute transverse myelitis (ATM): clinical review of 43 patients with COVID-19-associated ATM and 3 post-vaccination ATM serious adverse events with the ChAdOx1 nCoV-19 vaccine (AZD1222). Frontiers in immunology. 2021;12:879.

Michael L. Genetic Mutation Found in Familial Transverse Myelitis 2017 [Available from: https://wearesrna.org/genetic-mutation-found-familial-transverse-myelitis/.

Matsushita T, Masaki K, Isobe N, et al. Genetic factors for susceptibility to and manifestations of neuromyelitis optica. Annals of Clinical and Translational Neurology. 2020;7(11):2082-93. Doi:https://doi.org/10.1002/acn3.51147

Ligocki A, Rounds W, Cameron E, et al. Expansion of CD27 high plasmablasts in transverse myelitis patients that utilize VH4 and JH6 genes and undergo extensive somatic hypermutation. Genes & Immunity. 2013;14(5):291-301. Doi:10.1038/gene.2013.18

  • Abstract Viewed: 377 times

Download Statastics

  • Linkedin
  • Twitter
  • Facebook
  • Google Plus
  • Telegram

Developed By

Open Journal Systems
  • Home
  • Archives
  • Submissions
  • About the Journal
  • Editorial Team
  • Contact
Powered by OJSPlus