The Association of Acute Motor Axonal Neuropathy (Guillain-Barre’ Syndrome Variant) with Coronavirus (SARS-Cov-2) in a Child: A Case Report
Iranian Journal of Child Neurology,
Vol. 17 No. 2 (2023),
16 March 2023
,
Page 159-166
https://doi.org/10.22037/ijcn.v17i2.35849
Abstract
Various reports of neurological manifestations of SARS-COV-2 infection after the virus outbreak are available, including anosmia, seizures, acute flaccid myelitis, Guillain-Barré syndrome (GBS), and encephalitis. Most of the literature has focused on the respiratory manifestation of SARS-CoV-2 infection in adults, but recent evidence showed that it is not confined to the respiratory tract. This report is about a rare variant of GBS acute motor axonal neuropathy (AMAN) in a child due to COVID-19 infection An 11 years old boy was referred to the hospital with a history of three-day lasting mild fever, and gastroenteritis, two weeks before starting symptoms. He was presented with progressive ascending weakness, paresthesia, and areflexia in four limbs four days ago. Nasopharyngeal swab polymerase chain reaction (PCR) was positive for SARS-CoV-2. The electrodiagnostic finding was compatible with acute generalized axonal motor neuropathy, and imaging revealed thoracolumbar syrinx and nerve root enhancement in lumbosacral MRI. Other lab tests were normal. GBS and its variant are one of the manifestations of SARS-CoV-2 in children. Children with an unexplained neurological process should be tested for SARS-CoV-2.
- Guillain-Barré syndrome (GBS); Acute Axonal Motor Neuropathy (AMAN); COVID-19; Children
How to Cite
References
Whittaker, A., M. Anson, and A. Harky, Neurological manifestations of COVID‐19: a systematic review and current update. Acta Neurologica Scandinavica, 2020. 142(1): p. 14-22.
Frank, C.H.M., et al., Guillain–Barré syndrome associated with SARS-CoV-2 infection in a pediatric patient. Journal of tropical pediatrics, 2020.
Lowery, M.M., et al., Atypical variant of Guillain Barre syndrome in a patient with COVID-19. The Journal of Critical Care Medicine, 2020. 6(4): p. 231.
Willison, H.J., B.C. Jacobs, and P.A. van Doorn, Guillain-barre syndrome. The Lancet, 2016. 388(10045): p. 717-727.
Rahimi, K., Guillain-Barre syndrome during COVID-19 pandemic: an overview of the reports. Neurological Sciences, 2020: p. 1-8.
Donofrio, P.D., Guillain-Barré Syndrome. CONTINUUM: Lifelong Learning in Neurology, 2017. 23(5): p. 1295-1309.
Abu-Rumeileh, S., et al., Guillain–Barré syndrome spectrum associated with COVID-19: an up-to-date systematic review of 73 cases. Journal of neurology, 2020: p. 1-38.
Petrelli, C., et al., Acute Motor Axonal Neuropathy Related to COVID-19 Infection: A New Diagnostic Overview. Journal of Clinical Neuromuscular Disease, 2020. 22(2): p. 120-121.
Curtis, M., et al., Guillain-Barré syndrome in a child with COVID-19 infection. Pediatrics, 2021. 147(4).
Munhoz, R.P., et al., Neurological complications in patients with SARS-CoV-2 infection: a systematic review. Arquivos de Neuro-Psiquiatria, 2020. 78(5): p. 290-300.
Krishnakumar, A., et al., Guillain–Barré Syndrome with Preserved Reflexes in a Child after COVID-19 Infection. Indian Journal of Pediatrics, 2021: p. 1-2.
Gupta, P.K., et al., How different is AMAN from AIDP in childhood GBS? A prospective study from North India. The Indian Journal of Pediatrics, 2019. 86(4): p. 329-334.
- Abstract Viewed: 243 times