Evaluate serum proteome in women with obsessive-compulsive disorder/bipolar compared with pure OCD subjects as well as healthy controls
Iranian Journal of Child Neurology,
Vol. 17 No. 3 (2023),
17 July 2023
,
Page 133-142
https://doi.org/10.22037/ijcn.v17i1.34795
Abstract
Objectives
The present study aimed to evaluate the serum proteome of women with obsessive-compulsive disorder (OCD)/bipolar disorder (BP) compared to pure OCD subjects and healthy controls.
Materials & Methods
Serum proteome of women with OCD/BP, pure OCD individuals, and healthy controls were subjected to 2DE-based proteomics accompanied with MALDI-TOF-TOF mass spectrometry. Further evaluation of the identified protein spots with the significance of p<0.05 and fold≥1.5 was done by applying protein interaction mapping via Cytoscape v.5.3.1 and its plugins.
Results
The results indicate that vitamin D binding protein (GC) and haptoglobin spots (HP) significantly changed expression in OCD and OCD/BP with different expression patterns. These identified spots may contribute to OCD/BP and act as differentially recognized biomarkers comparing pure OCD and OCD/BP.
Conclusion
The Findings imply that these proteins in the serum of the patients could be potential distinguishable biomarkers in clinical usage after related validation experiments. Therefore, this study provides a preliminary evaluation to understand OCD/BP proteome behavior better.
- Obsessive Compulsive Disorder; Bipolar disorder; Comorbidity, Proteomics, 2D electrophoresis, Serum Profiling
How to Cite
References
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