Risk Factors for Birth Asphyxia in an Urban Health Facility in Cameroon
Iranian Journal of Child Neurology,
Vol. 7 No. 3 (2013),
28 August 2013
,
Page 46-54
https://doi.org/10.22037/ijcn.v7i3.3473
Abstract
How to Cite This Article: Chiabi A, Nguefack S, Mah E, Nodem S, Mbuagbaw L, Mbonda E, Tchokoteu PF, Doh A. Risk Factors for Birth Asphyxia in an Urban Health Facility in Cameroon. Iran J Child Neurol. 2013 Summer; 7(3):46-54.
Objective
The World Health Organization (WHO) estimates that 4 million children are born with asphyxia every year, of which 1 million die and an equal number survive with severe neurologic sequelae. The purpose of this study was to identify the risk factors of birth asphyxia and the hospital outcome of affected neonates.
Materials & Methods
This study was a prospective case-control study on term neonates in a tertiary hospital in Yaounde, with an Apgar score of < 7 at the 5th minute as the case group, that were matched with neonates with an Apgar score of ≥ 7 at the 5th minute as control group. Statistical analysis of relevant variables of the mother and neonates was carried out to determine the significant risk factors.
Results
The prevalence of neonatal asphyxia was 80.5 per 1000 live births. Statistically significant risk factors were the single matrimonial status, place of antenatal visits, malaria, pre-eclampsia/eclampsia, prolonged labor, arrest of labour,
prolonged rupture of membranes, and non-cephalic presentation. Hospital mortality was 6.7%, that 12.2% of them had neurologic deficits and/or abnormal transfontanellar ultrasound/electroencephalogram on discharge, and 81.1% had
a satisfactory outcome.
Conclusion
The incidence of birth asphyxia in this study was 80.5% per1000 live birth with a mortality of 6.7%. Antepartum risk factors were: place of antenatal visit, malaria during pregnancy, and preeclampsia/eclampsia. Whereas prolonged labor, stationary labor, and term prolonged rupture of membranes were intrapartum risk faktors. Preventive measures during prenatal visits through informing and communicating with pregnant women should be reinforced.
References
1. World Health Organisation. Perinatal mortality: a listing
of available information. WHO/frh/msm/96.7.Geneva: WHO;1996.
2. Lawn JE, Cousens S, Zupan J; Lancet Neonatal Survival
Steering Team. 4 million neonatal deaths: When? Where?
Why? Lancet 2005;365;891-900.
3. Bryce J, Boschi-Pinto C, Shibuya K, Black RE, WHO Child Health Epidemiology Reference Group. WHO estimates of the causes of death in children. Lancet 2005;365:1147-52.
4. United Nations. The Millenium Development Goals Report 2010. New York; 2010
5. Boog G. La souffrance foetale aigue. J Gynecol Obstet
Biol Reprod 2001;30:393-432.
6. Zupan-Simunek V. Définition de l’asphyxie intrapartum
et conséquences sur le devenir. J Gynecol Obstet Biol
Reprod 2008;37S: S7-S15.
7. McGuire W. Perinatal asphyxia. Available from: http://
www.bestpractice.bmj.com/best-practice/evidence/ background/0320.html. (Accessed 2/3/2010).
8. De Vries LS, Jongmans MJ. Long-term outcome after
neonatal hypoxic-ischaemic encephalopathy. Arch Dis
Child Fetal Neonatal Ed 2010;95:F220-F4.
9. Dilenge ME, Majnemer A, Shevell MI. Long-term developmental outcome of asphyxiated term neonates. J
Child Neurol 2001;16:781-92.
10. Haider BA, Bhutta ZA. Birth asphyxia in developing countries: Current status and public health implications. Curr Probl Pediatr Adolesc Health Care 2006;6:178-88.
11. Badawi N, Kurinczuk JJ, Keogh JM, Alessandri LM, O’Sullivan F, Burton PR, et al. Intrapartum risk factors for newborn encephalopathy: the Western Australian case-control study. BMJ 1998;317(7172):1554-8.
12. Badawi N, Kurinczuk JJ, Keogh JM, Alessandri LM, O’Sullivan F, Burton PR, et al. Antepartum risk factors for newborn encephalopathy: the Western Australian case-control study. BMJ 1998;317(7172):1549-53.
13. Arniel-Tison C, Ellison P. Birth asphyxia in the full term newborn: early assessment and outcome. Dev Med Child Neurol 1986;28: 671-82.
14. Sarnat HB, Sarnat MS. Neonatal encephalopathy following fetal distress. Arch Neurol 1976;33:696-705.
15. Sullivan KM, Soe MM: Sample size for a cross-sectional, cohort, or clinical trial studies. Available from: http:// www.openepi.com/Documentation/SSCohortdoc.htm.(Accessed 25/4/2011)
16. Zupan-Simunek V, Razafimahefa H, Caeymaex L. Pronostic neurologique des asphyxies perinatales à terme. J Gynecol Obstet Biol Reprod 2003;32:85-90.
17. Monebenimp F, Tietche F, Eteki N. Asphyxie néonatale au centre hospitalier universitaire de Yaoundé. Clin Mother Child Health 2005;2:335-8.
18. Douba EC. Souffrance cérébrale asphyxique du nouveauné
a terme au Centre Mère-Enfant de Yaoundé. MD thesis. Faculty of Medicine and Biomedical Sciences, University of Yaounde I; 2007.
19. Airede AI. Birth asphyxia and hypoxic- ischemic encephalopathy incidence and severity. Ann Trop Pediatr
1991;11(4): 331-5.
20. Ogunlesi TA, Oseni SB. Severe birth asphyxia in Wesley
Guild hospital: A persistent plague!. Niger Med Pract 2008;53(3):40-3.
21. Thornberg E, Thiringer K, Odeback A, Milson I. Birth asphyxia: incidence, clinical course and outcome in a
Swedish population. Acta Pediatr 1995;84(8):1927-32.
22. Gonzales de Dios J, Moya M. Perinatal difference in asphyxic full terms newborn: an epidemiological study. Rev Neurol 1996; 24:812-9.
23. Chandra S, Ramji S, Thirupuram S. Perinatal asphyxia: multivariate analysis of risk factors in hospital births. India Pediatr 1997;34(3):206-12.
24. Muhammad A. Birth asphyxia. Professional Med J
2004;11(4): 416-22.
25. Johnston MV, Hagberg H. Sex and the pathogenesis of
cerebral palsy. Dev Med Child Neurol 2007;49:74-8.
26. Raatikainen K, Heiskanen N, Heinoven S. Marriage still
protects pregnancy. BJOG 2003;112(10): 1411-6.
27. Houndjahoué GFH. Etude de la mortalité néonatale due à
l’asphyxie dans le district sanitaire de Kolokani au Mali (Thèse de Doctorat en Médecine). Faculté de Médecine, de Pharmacie et d’Odonto-Stomatologie. Université de Bamako; 2004.
28. Kinoti SN. Asphyxia of the newborn in East, Central and
Southern Africa. East Afr Med J 1993;70(7):422-33.
29. Rehana M, Yasmeen M, Farrukh M, Naheed PS, Uzma DM. Risk factors of birth asphyxia. J A M C. 2007;19(3):67-71.
30. Diallo S, Kourouma ST, Camara YB. Mortalité néonatale à l’institut de nutrition et de santé de l’enfant (INSE), Conakry-République de Guinée. Med Afr Noire 1998;45(5):326-9.
31. Victory R, Penava D, Dasilva O, Natale R, Richardson B. Umbilical cord pH and base excess values in relation to adverse outcome events for infants delivering at term. Am J Obstet Gynecol 2004;191(6):2021-8.
32. Meka LR. Evaluation de la prise en charge des nouveaunés
en salle de naissance : cas de l’Hôpital Gynéco- Obstétrique et Pédiatrique de Yaoundé (MD Thesis). Faculty of Medicine and Biomedical Sciences. Yaoundé: University of Yaounde I; 2008.
33. World Health Organization. WHO Antenatal care randomized trial: manual for the implementation of the new model. Geneva: World Health Organization; 2002.
34. Institut National de la Statistique (INS) et ORC Macro.
Enquête démographique et de santé du Cameroun. Calverton Maryland, USA : INS et ORC Macro; 2004
35. Kumari S, Sharma M, Yuadav M, Saraf A, Kabra M,
Merha R. Trends in neonatal outcome with low Apgar score. India J Pediatr 1993; 60(3):415-22.
36. Boeuf P, Tan A, Romagosa C, Radford J, Mwapasa V, Molyneux ME, et al. Placental hypoxia during placental
malaria. J Infect Dis 2008;197(5):757-65.
37. Brahim BJ, Johnson PM. Placental malaria and preeclampsia
through the looking glass backwards? J Reprod Immunol 2005; 65(1):1-15.
38. Ellis M, Manandhar N, Manandhar DS, Costello AM. Risk factors for neonatal encephalopathy in Kathmandu, Nepal, a developing country: unmatched case-control study. BMJ 2000;320:1229-36.
- Birth asphyxia
- Neonates
- Hospital outcome
- Cameroon
How to Cite
- Abstract Viewed: 1369 times