Primary spinal tumors and masses in children: a study of 37 cases
Iranian Journal of Child Neurology,
Vol. 16 No. 2 (2022),
14 March 2022
,
Page 129-135
https://doi.org/10.22037/ijcn.v16i2.30614
Abstract
Abstract
Objectives
Spinal cord tumors are a rare diagnosis in children, mostly presented with unspecific symptoms which may pose a problem due to their possible malignancy and further complications. Yet there is little data regarding spinal cord lesions in our country.
The aim of this study is to present a series of 37 cases of primary spinal tumors treated at the same institution and briefly review their pathology, symptoms and site of occurrence.
Materials & Methods
37 cases of spinal cord tumors and masses were selected from March 2007 to 2017, excluding spinal dysraphism. Data regarding age, sex, clinical presentation, location of the mass, and pathology were retrospectively collected.
Results
Mean age at diagnosis was 5 years and 8 months (standard deviation: 4.1 years). 21 were male and 16 were female (male-to-female ratio: 1.31). Pathological findings were 9 Neuroepitheliomas (6 Neuroblastoma, 2 Ganglioneuroma, 1 Ganglioneuroblastoma/Ganglioneuroma), 4 Ependymomas, 3 Primitive Neuroectodermal Tumors, 3 Glial tumors, 4 Neurodevelopmental tumors, 3 Lymphomas, 1 Hemangiopericytoma and 1 Neurofibroma. 26 patients had Motor symptoms (74.2%), 14 had pain (40%), 6 showed sensory symptoms (16.6%) and 4 had urinary symptoms (11.4%). The most common location of occurrence was the lumbosacral region.
conclusion
While differing in pathological composition and location of tumors in comparison to other papers, our study presents possible presentations and/or expected pathologies in pediatric spinal cord tumors.
- Spinal Cord Neoplasms
- Neurosurgery
- Pediatrics
How to Cite
References
References:
Ching L, Wan-Yee T. Epidemiology of central nervous system tumors in children. In: UpToDate. 2017.
Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer. 2010;127(12):2893–917.
Hsu W, Jallo GI. Pediatric spinal tumors [Internet]. Handbook of Clinical Neurology. Elsevier B.V.; 2013. 112 (1) 959–965 p.
Jazayeri SB, Rahimi-Movaghar V, Shokraneh F, Saadat S, Ramezani R. Epidemiology of primary CNS tumors in Iran: A systematic review. Asian Pacific J Cancer Prev. 2013;14(6):3979–85.
Duong LM, McCarthy BJ, McLendon RE, Dolecek TA, Kruchko C, Douglas LL, et al. Descriptive epidemiology of malignant and nonmalignant primary spinal cord, spinal meninges, and cauda equina tumors, United States, 2004-2007. Cancer. 2012;118(17):4220–7.
Jallo GI, Freed D, Epstein F. Intramedullary spinal cord tumors in children. Child’s Nerv Syst. 2003;19(9):641–9.
Schellinger KA, Propp JM, Villano JL, McCarthy BJ. Descriptive epidemiology of primary spinal cord tumors. J Neurooncol. 2008;87(2):173–9.
Wilson PE, Oleszek JL, Clayton GH. Pediatric spinal cord tumors and masses. J Spinal Cord Med. 2007;30(SUPPL. 1) 15–20.
Kutluk T, Varan A, Kafali C, Hayran M, Söylemezoʇlu F, Zorlu F, et al. Pediatric intramedullary spinal cord tumors: A single center experience. Eur J Paediatr Neurol. 2015;19(1):41–7.
Merlot I, Francois J, Marchal JC, Joud A, Guerbouz R, Chastagner P, et al. Spinal cord tumors in children: A review of 21 cases treated at the same institution. Neurochirurgie [Internet]. 2017;63(4):291–6. Available from: http://dx.doi.org/10.1016/j.neuchi.2017.01.008
Auguste KI, Gupta N. Pediatric intramedullary spinal cord tumors. Neurosurg Clin N Am. 2006;17(1):51–61.
Huisman TAGM. Pediatric tumors of the spine. Cancer Imaging. 2009;9(SPEC. ISS. A):45–8.
O’Sullivan C, Jenkin RD, Doherty MA, Hoffman HJ, Greenberg ML. Spinal cord tumors in children: Long-term results of combined surgical and radiation treatment. Vol. 81, Journal of Neurosurgery. 1994. 81(4): 507-12
- Abstract Viewed: 368 times