Assessment of Hearing Loss in 2-years Follow up study of Neonates with Congenital Cytomegalovirus Infection
Iranian Journal of Child Neurology,
Vol. 16 No. 2 (2022),
14 March 2022
,
Page 17-26
https://doi.org/10.22037/ijcn.v16i2.30592
Abstract
Objective: Congenital CMV infection constitutes the main cause of sensory neural hearing loss (SNHL) worldwide. The rate of CMV induced SNHL is not well documented in developing countries like Iran. Therefore, this prospective follow up study was aimed to evaluate this rate among neonates with congenital CMV infection.
Materials & Methods: Infants with congenital CMV infection who were admitted to Neonatal Intensive Care Units and infected infants who were identified in 2 other prospective screening studies in our region were enrolled. Audiological follow up was performed for all the cases. Antiviral therapy was administered for the newborns in case of having severe symptoms.
Results: A total of 22 infants with congenital CMV infection were entered into the study, of which, 8 and 14 had symptomatic and asymptomatic congenital CMV infection, respectively. In total, 3 of 22 infants had SNHL (13.6%; 95% CI: 2.8-39.8), 2 of 8 with symptomatic cCMV infection (25.0%; 95% CI: 3-90) and 1 of 14 with asymptomatic cCMV infection (7.1%; 95% CI: 0.1-39). No association was found between SNHL and risk factors related to CMV in newborns.
In conclusion, the findings of this study revealed that the rate of congenital CMV induced SNHL is high among neonates how born in our region. Severe sequelae of congenital CMV infection indicate the need for screening for CMV infection at birth to reduce the risk of CMV complications and the financial load of treatment imposed on health care and treatment systems in the country.
- Congenital CMV infection
- Hearing Loss
- Newborns
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References
References
Yola DE, Demmler GJ, Nelson CT, et al. Early predictors of neurodevelopmental outcome in symptomatic congenital cytomegalovirus infection. J Pediatr. 2001;138:325.
Atkinson C, Emery V, Griffiths P. Development of a novel single tube nested PCR for enhanced detection of cytomegalovirus DNA from dried blood spots. Journal of virological methods. 2014;196:40-4.
Kenneson A, Cannon MJ. Review and meta‐analysis of the epidemiology of congenital cytomegalovirus (CMV) infection. Reviews in medical virology. 2007;17(4):253-76.
Ludwig A, Hengel H. Epidemiological impact and disease burden of congenital cytomegalovirus infection in Europe. Eurosurveillance. 2009;14(9):26-32.
Natale F, De Curtis M, Bizzarri B, Orlando MP, Ralli M, Liuzzi G, et al. Isolated auditory neuropathy at birth in congenital cytomegalovirus infection. Italian Journal of Pediatrics. 2020;46(3):1-7.
Pass R. Congenital cytomegalovirus infection and hearing loss. Herpes: the journal of the IHMF. 2005;12(2):50-5.
Dahle AJ, Fowler KB, Wright JD, Boppana SB, Britt WJ, Pass RF. Longitudinal investigation of hearing disorders in children with congenital cytomegalovirus. Journal of the American Academy of Audiology. 2000;11(5).
Fowler KB, Boppana SB. Congenital cytomegalovirus (CMV) infection and hearing deficit. J Clin Virol. 2006;35(2):226-31.
Kummer P., Marcrum SC. Potential Benefit of Selective CMV Testing after Failed Newborn Hearing Screening. In J Neonatal Screen. 2018;20(4):1-15. doi:10.3390/ijns4020020.
Ross SA, Fowler KB, Ashrith G, Stagno S, Britt WJ, Pass RF, et al. Hearing loss in children with congenital cytomegalovirus infection born to mothers with preexisting immunity. The Journal of pediatrics. 2006;148(3):332-6.
Foulon I, Naessens A, Foulon W, Casteels A, Gordts F. A 10-year prospective study of sensorineural hearing loss in children with congenital cytomegalovirus infection. The Journal of pediatrics. 2008;153(1):84-8.
Noorbakhsh S, Farhadi M, Haghighi F, Minaeian S, Haghighi H.M. Neonatal screening for congenital cytomegalovirus infection in Tehran, Iran, using Guthrie cards. IRAN J MICROBIOL. 2020;12(3):198-203.
Noorbakhsh S., Farhadi M., Rezaei F., Emam Jomeh H., Farahmand M., Haghighi F., et al. Prevalence of Congenital Cytomegalovirus Infection Among Hospitalized Neonates in Tehran, Iran. Iran Red Crescent Med J. 2020;22(10):e66.
de Vries JJ, Barbi M, Binda S, Claas EC. Extraction of DNA from dried blood in the diagnosis of congenital CMV infection. Methods Mol. Biol. 2012;903, 169-175
Flexer CA. Pediatric audiology: Diagnosis, technology, and management. Thieme; 2008.
Yamamoto AY, Mussi-Pinhata MM, Lima Isaac MD, Amaral FR, Carvalheiro CG, Aragon DC, Congenital Cytomegalovirus Infection as a Cause of Sensorineural Hearing Loss in a Highly Immune Population. Pediatr Infect Dis J. 2011;30(12):1-10.
Korver AM, Konings S, Dekker FW, Beers M, Wever CC, Frijns JH, et al. Newborn hearing screening vs later hearing screening and developmental outcomes in children with permanent childhood hearing impairment. Jama. 2010;304(15):1701-8.
Fakhim SA, Naderpoor M, Shahidi N, Basharhashemi F, Nejati N, Sakha SH, et al. Study of prevalence and causes of hearing loss in high risk neonates admitted to neonatal ward and neonatal intensive care unit. Int Adv Otol. 2010;6:365-70.
Farhat AS, Ghasemi MM, Akhondian J, Mohamadzadeh A, Esmaeili H, Amiri R, et al. Assessment of the prevalence of Hearing Impairment in Neonates Born in Imam Reza, Ghaem and OM-Albanin Hospitals of Mashhad. Iranian Journal of Neonatalogy. 2014;5(2):17-20.
Islami Z, Baradaranfar MH, Mehrparvar AH, Mollasadeghi A, Mostaghaci M, Naghshineh E. Frequency of Hearing Impairment among Full-term Newborns in Yazd, Iran. Iranian Journal of Pediatrics. 2013;23(3):349-52.
Karimian P, Yaghini O, Nasr Azadani H, Mohammadizadeh M, Arabzadeh SAM, Adibi A, et al. Prevalence, characteristics, and one-year follow-up of congenital cytomegalovirus infection in Isfahan City, Iran. Interdisciplinary perspectives on infectious diseases. 2016:1-8.
Rawlinson WD, Palasanthiran P, Hall B, Al Yazidi L, Cannon MJ, Cottier C, et al. Neonates with congenital Cytomegalovirus and hearing loss identified via the universal newborn hearing screening program. J Clin Virol. 2018;102:110-5.
Fowler KB, McCollister FP, Sabo DL, Shoup AG, Owen KE, Woodruff JL, et al. A Targeted Approach for Congenital Cytomegalovirus Screening Within Newborn Hearing Screening. Pediatrics. 2017;139(2):2016-28.
Korver AM, de Vries JJ, Konings S, de Jong JW, Dekker FW, Vossen AC, et al. Congenital cytomegalovirus infection in young children with permanent bilateral hearing impairment in the Netherlands. J Clin Virol. 2009;46(4):007.
Yamamoto AY, Mussi-Pinhata MM, Boppana SB, Novak Z, Wagatsuma VM, de Frizzo Oliveira P, et al. Human cytomegalovirus reinfection is associated with intrauterine transmission in a highly cytomegalovirus-immune maternal population. American journal of obstetrics and gynecology. 2010;202(3):297. e1-. e8.
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