A case of recurrent urinary tract infections with neurogenic bladder due to spinal tumors
Iranian Journal of Child Neurology,
Vol. 15 No. 1 (2021),
1 January 2021
,
Page 119-124
https://doi.org/10.22037/ijcn.v15i2.27793
Abstract
Neuroblastic tumors are the most common extracranial solid tumors in children. They are manifested by different clinical presentations ranging from cord compression symptoms to asymptomatic cases. A 2.5-year girl with a history of vaginal delivery at 39 gestational weeks and low Apgar score presented by repeated episodes of urinary tract infections and progressive paraplegia started at the age of 8 months.
Brain MRI and EEG were normal. Voiding cystourethrography revealed grade II vesicoureteral reflux in the left kidney. Lumbar MRI with and without contrast showed a dumbbell shape mass, the hyper signal in T2 -weighted image and low signal in T1 -weighted image, extramedullary, and intramural with mass effect on the cord.
Microscopic examination of tissue obtained by surgery reported ganglioneuroma.
Our case was interesting because of her presentation, neurogenic bladder associated with repeated episodes of urinary tract infections, and secondary paraplegia. Neurogenic bladder dysfunction is rarely reported in cases with ganglioneuroma.
- Neurogenic bladder
- Recurrent UTI
- Spinal tumors
- Ganglioneuroma
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References
Kaatsch P. Epidemiology of childhood cancer. Cancer Treat Rev 2010; 36(4):277-85.
Shimada H, Ambros IM, Dehner LP, Hata J, Joshi VV, Roald B. Terminology and morphologic criteria of neuroblastic tumors: recommendations by the International Neuroblastoma Pathology Committee. Cancer 1999; 86(2):349–63.
Cronin EM, Coffey JC, Herlihy D, Romics L, Aftab F, Keohane C, et al. Massive retroperitoneal ganglioneuroma presenting with small bowel obstruction 18 years following initial diagnosis. Ir J Med Sci 2005; 174(2):63–6.
Ponce-Camacho MA, Diaz de Leon-Medina R, Miranda-Maldonado I, Garza-Guajardo R, Hernandez-Salazar J, Barboza-Quintana O. A 5-year-old girl with a congenital ganglioneuroma diagnosed by fine needle aspiration biopsy: a case report. Cytojournal 2008; 5:5.
Decarolis B, Simon T, Krug B, Leuschner I, Vokuhl C, Kaatsch P, et al .Treatment and outcome of ganglioneuroma and ganglioneuroblastoma intermixed. BMC Cancer 2016; 6:542.
Geoerger B , Hero B, Harms D, Grebe J, Scheidhauer K, Berthold F. Metabolic activity and clinical features of primary ganglioneuromas. Cancer 2001; 15; 91(10):1905-13.
Huang Y, Lyu ZS, Liu LD, Wu D, Li Qiao, Zhang SK. Clinical characteristics and surgical treatment of ganglioneuroma in spine. Zhongguo Gu Shang 2015; 28(11):1013-6.
Przkora R, Perez-Canto A, Ertel W, Heyde CE. Ganglioneuroma: primary tumor or maturation of a suspected neuroblastoma? Eur Spine J 2006; 15(3):363-5.
Thway K, Fisher C. Diffuse ganglioneuromatosis in small intestine associated with neurofibromatosistype 1. Ann Diagn Pathol 2009; 13(1):50-4.
Miyakoshi N, Hongo M, Kasukawa Y, Misawa A, Shimada Y.Bilateral and symmetric C1-C2 dumbbell ganglioneuromas associated with neurofibromatosis type 1 causing severe spinal cord compression. Spine 2010; 10(4):e11-5.
Ljung R, Helin I, Strömblad LG. Ganglioneuroma with an uncommon location in a six-year-old girl. Acta Paediatr Scand. 1984; 73(3):411-3.
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