Intracranial angiomatoid fibrous histiocytoma: report of a rare case
Iranian Journal of Child Neurology,
Vol. 16 No. 3 (2022),
16 Tir 2022
,
Page 205-212
https://doi.org/10.22037/ijcn.v15i4.26805
Abstract
One rare and low-grade soft tissue tumor with intermediate malignant potential is angiomatoid fibrous histiocytoma (AFH) و which occurs mainly in children and adolescents. The tumor naturally tends to local
recurrence and recurrent hemorrhage but rarely to remote metastasis.
AFH has been reported in different organs; however, there are rare reports of primary intracranial AFH. The diagnosis of AFH may be difficult due to its occurrence at multiple unusual anatomic sites and its spectrum of morphologic patterns; thus, it is especially importantto diagnose it correctly because of the small risk of metastasis and death. The lesion is simply confused with a hematoma, soft tissue hemangioma, or malignant fibrous histiocytoma from clinical and radiographical aspects.
We report a case of intracranial AFH in a 5-year-old boy. The tumor is a heterogeneous intra-axial with a size of 78*73mm at the right front temporal. There was also an extra-axial mass measured 8*12mm at the left superior frontal lobe in favor of metastasis. The diagnosis was confirmed using radiographical, immunohistochemical, and molecular tests.
AFH is a rare tumor with a high probability of misdiagnosis. Surgeons must be aware of the presence of AFH and conduct a careful followup
- Histiocytoma
- Malignant Fibrous
- Seizures
- Brain Neoplasms
- pediatrics
How to Cite
References
Chu Y-N, Chen C-J, Liang C-W, Hsu H-C. An unusual histopathologic feature of angiomatoid fibrous histiocytoma–A case report and molecular study. Dermatologica Sinica. 2018.
Enzinger FM. Angiomatoid malignant fibrous histiocytoma. A distinct fibrohistiocytic tumor of children and young adults simulating a vascular neoplasm. Cancer. 1979;44(6):2147-57.
Alshareef MA, Almadidy Z, Baker T, Perry A, Welsh CT, Vandergrift III WA. Intracranial angiomatoid fibrous histiocytoma: case report and literature review. World neurosurgery. 2016;96:403-9.
Sánchez-Garcîa I. Angiomatoid fibrous histiocytoma (AFH). Atlas of genetics and cytogenetics in oncology and haematology. 2006;10(2):127-30.
Huerter ME, Hammadeh R, Zhou Q, Riker AI. Recurrent angiomatoid fibrous histiocytoma: a case report and review of the literature. The Ochsner Journal. 2014;14(3):441-4.
Matushansky I, Charytonowicz E, Mills J, Siddiqi S, Hricik T, Cordon-Cardo C. MFH classification: differentiating undifferentiated pleomorphic sarcoma in the 21st century. Expert review of anticancer therapy. 2009;9(8):1135-44.
Saito K, Kobayashi E, Yoshida A, Araki Y, Kubota D, Tanzawa Y, et al. Angiomatoid fibrous histiocytoma: a series of seven cases including genetically confirmed aggressive cases and a literature review. BMC musculoskeletal disorders. 2017;18(1):31.
Costa MJ, Weiss SW. Angiomatoid malignant fibrous histiocytoma. A follow-up study of 108 cases with evaluation of possible histologic predictors of outcome. The American journal of surgical pathology. 1990;14(12):1126-32.
Fanburg-Smith J, Miettinen M. Angiomatoid “malignant” fibrous histiocytoma: a clinicopathologic study of 158 cases and further exploration of the myoid phenotype. Human pathology. 1999;30(11):1336-43.
Shi H, Li H, Zhen T, Zhang F, Dong Y, Zhang W, et al. Clinicopathological features of angiomatoid fibrous histiocytoma: a series of 21 cases with variant morphology. International journal of clinical and experimental pathology. 2015;8(1):772.
Kao Y-C, Lan J, Tai H-C, Li C-F, Liu K-W, Tsai J-W, et al. Angiomatoid fibrous histiocytoma: clinicopathological and molecular characterisation with emphasis on variant histomorphology. Journal of Clinical Pathology. 2014;67(3):210-5.
Chen G, Folpe AL, Colby TV, Sittampalam K, Patey M, Chen M-G, et al. Angiomatoid fibrous histiocytoma: unusual sites and unusual morphology. Modern Pathology. 2011;24(12):1560.
Li C-S, Chan WP, Chen W-T, Chang C-P, Shih L-S, Chen R-C, et al. MRI of angiomatoid fibrous histiocytoma. Skeletal radiology. 2004;33(10):604-8.
Billings SD, Folpe AL. Cutaneous and subcutaneous fibrohistiocytic tumors of intermediate malignancy: an update. The American journal of dermatopathology. 2004;26(2):141-55.
Kim K, Lee J-S, Cho K-J. Angiomatoid fibrous histiocytoma. Korean J Pathol. 2006;40:377-80.
Davis AM, O'Sullivan B, Turcotte R, Bell R, Catton C, Chabot P, et al. Late radiation morbidity following randomization to preoperative versus postoperative radiotherapy in extremity soft tissue sarcoma. Radiotherapy and oncology. 2005;75(1):48-53.
García JJ, Folpe AL. The impact of advances in molecular genetic pathology on the classification, diagnosis and treatment of selected soft tissue tumors of the head and neck. Head and neck pathology. 2010;4(1):70-6.
Asakura S, Tezuka N, Inoue S, Kihara N, Fujino S. Angiomatoid fibrous histiocytoma in mediastinum. The Annals of thoracic surgery. 2001;72(1):283-5.
- Abstract Viewed: 239 times