Epidemiology of Guillain-BarréSyndrome in Iranian Children Aged 0-15 Years (2008-2013)
Iranian Journal of Child Neurology,
Vol. 15 No. 4 (2021),
1 October 2021
Objective: Guillain-Barre Syndrome (GBS) is an acute inflammatory polyneuropathy characterized by a rapid progressive symmetric weakness. This is the most common cause of Acute Flaccid Paralysis (AFP) in most parts of the world. This study was carried out to investigate the epidemiological features of GBS in Iranian children.
Materials & Methods: Data were extracted using the AFP surveillance system: a National screening program to detect all cases of AFP aged 0-15 years, around the country. National Population Statistics data and AFP demographic data during 2008-2013 intervals was obtained from the relevant authorities in ministry of health. GBS cases were then extracted from this data base. Chi-square and Fisher's exact test were used for statistical analysis.
Results: 1884 cases of GBS were identified in years of study and average annual incidence rate was 1.72 per 100,000 populations. The highest incidence rate was in the range of 0-5 years. There was no statistically significant relation between the incidence of GBS and the season in the whole country.
Conclusion: High costs of GBS treatment, morbidity and occasional mortality and the number of new cases which is estimated to be about 300 people per year, need particular attention of health system.
- Guillain-Barré Syndrome
How to Cite
McGrogana A, Madleb GC, Seamanb HE, de Vries CS. The Epidemiology of Guillain-Barré Syndrome Worldwide: a Systematic Literature Review. Neuroepidemiology 2009; 32: 150–63.
Govoni V, Granieri E: Epidemiology of the Guillain-Barre syndrome. Curr Opin Neurol
; 14: 605–613.
Hughes RAC, Rees JH. Clinical and epidemiologic features of Guillain-Barre syndrome. J Infect Dis 1997; 176 (suppl 2): S92–S98.
Rosen AB. Guillain-Barre´ Syndrome. Pediatrics in Review April 2012; 33(4): 164-71.
Congia S, Melis M, Carboni MA. Epidemiologic and clinical features of the Guillain-Barre´ syndrome in Sardinia in the 1961–1980 periods. Acta Neurol 1989; 11: 15–20.
Kaplan JE, Poduska PJ, McIntosh GC, Hopkins RS, Ferguson SW, Schon berger LB. GBS in Lorimer County Colorado: a high incidence area. Neurology 1985; 35: 581–4.
Hughes RA, Rees JH: Clinical and epidemiologic features of Guillain-Barre syndrome. J
Infect Dis 1997; 176: 92–98.
Olive JM, Castillo C, Garcia Castro R, de Quadros CA. Epidemiologic study of Guillain-Barre syndrome in children <15 years of age in Latin America. J Infect Dis 1997;
Peric1 S, Milosevic V, Berisavac I, Stojiljkovic O, Bumbasirevic LB, Marjanovic I, et al. Clinical and epidemiological features of Guillain-Barré syndrome in the Western Balkans. Journal of the Peripheral Nervous System 2014; 19:317–321.
Islam Zh, Jacobs BC, Islam MB, Mohammad QD, Diorditsa S, and Endtz HP. High Incidence of Guillain-Barré Syndrome in Children, Bangladesh. Emerging Infectious Diseases July 2011; 17 (7): 1317-18.
Barzegar M, Dastgiri S, Karegarmaher MH and Varshochiani A. Epidemiology of childhood Guillan-Barre syndrome in the north west of Iran. BMC Neurology 2007; 7: 22: 1-5.
González-Suárez I, Sanz-Gallego I, Rodríguez de Rivera FJ, Arpa J. Guillain-Barré syndrome: natural history and prognostic factors: a retrospective review of 106 cases. BMC Neurol 2013; 13:95
Vajsar J, Fehlings D, Stephens D. Long-term outcome in children with Guillain-Barré syndrome. J Pediatr. 2003 Mar; 142 (3): 305-9.
Molinero MR, Varon D, Holden KR, Sladky JT, Molina IB, Cleaves F. Epidemiology of Childhood Guillain-Barré Syndrome as a Cause of Acute Flaccid Paralysis in Honduras: 1989–1999. Journal of Child Neurology 2003 November; 18 (11): 741-7.
Storey E, Cook M, Peppard R, Newton-John H, Byrne E. Guillain-Barre syndrome and
related conditions in Victorian teaching hospitals 1980–1984. Aust NZ J Med 1989; 19:
Arami MA, Yazdchi M, Khandaghi R: Epidemiology and characteristics of Guillain Barre syndrome in the northwest of Iran. Ann Saudi Med 2006; 26: 22–27.
Govoni V, Granieri E, Tola MR, Casetta I, Ruppi P, Vaghi L. The frequency of clinical variants of Guillain-Barre syndrome in Ferrara, Italy. J Neurol 1999; 246: 1010–1014.
Sedano MJ, Calleja J, Canga E, Berciano J. Guillain-Barre syndrome in Cantabria, Spain: an epidemiological and clinical study. Acta Neurol Scand 1994; 89: 287–292.
Rocha MS, Brucki SM, Carvalho AA, Lima UW. Epidemiologic features of Guillain Barre Syndrome in Sao Paulo, Brazil. Arq Neuropsiquiatr 2004; 62: 33–37.
van Koningsveld R, van Doorn PA, Schmitz PI, Ang CW, van der Meche FG. Mild forms of Guillain-Barre syndrome in an epidemiologic survey in The Netherlands. Neurology 2000; 54: 620–625.
Wu X, Shen D, Li T, Zhang B, Li Ch, Mao M, et al. Distinct clinical characteristics of pediatric Guillain-Barré Syndrome: A comparative study between children and adults in northeast China. PLoS ONE 11(3)
Rees JH, Thompson RD, Smeeton NC, Hughes RAC. Epidemiological study of Guillain-Barre Syndrome in south east England. J Neurol Neurosurg Psychiatry 1998; 64: 74–77.
Winer JB. Guillain Barre Syndrome. Mol Pathol 2001; 54: 381–385.
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