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Efficacy of Continuous High Dose Midazolam Infusion in Childhood Refractory Generalized Convulsive Status Epilepticus

  • Afshin Fayyazi
  • Parvaneh Karimzadeh

Iranian Journal of Child Neurology, Vol. 5 No. 3 (2011), 17 September 2011 , Page 15-17
https://doi.org/10.22037/ijcn.v5i3.2401 Published 17 September 2011

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Abstract

Objecive

Prolonged and uncontrolled refractory status epilepticus (SE) is a life-threatening medical emergency in children (1,2,3). There is no consensus on the optimal therapy for refractory status epilepticus (1). The aim of this study was to develop a new method for treating patients with refractory status epilepticus.

Materials & Methods

Ten children with refractory status epilepticus in Mofid Hospital, who did not respond to 10 μg/kg per min of intravenous midazolam, had their dose of midazolam increased to 30 μg/kg per min. All children were monitored for the development of side effects.

Results

Ten children with no response to low-dose midazolam were given a higher dose of midazolam, and 5 (50%) children had a good response. These patients had significantly different response to high-dose midazolam.

One patient in the high-dose midazolam group was intubated and required mechanical ventilation. The duration of stay in the hospital and PICU and on mechanical ventilation in patients with no response to low-dose midazolam following with other drugs was longer than in the high-dose midazolam group.

No death occurred in high dose midazolam group.

Conclusion

High-midazolam dose drip infusion is a safe and effective protocol for refractory status epilepticus in children.

Keywords:

Refractory status epilepticus; midazolam; mortality; childhood
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How to Cite

Fayyazi, A., & Karimzadeh, P. (2011). Efficacy of Continuous High Dose Midazolam Infusion in Childhood Refractory Generalized Convulsive Status Epilepticus. Iranian Journal of Child Neurology, 5(3), 15-17. https://doi.org/10.22037/ijcn.v5i3.2401
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