Serum Zinc level in Children with Febrile Seizure: A Case – Control Study
Iranian Journal of Child Neurology,
Vol. 14 No. 1 (2020),
1 January 2020
,
Page 43-47
https://doi.org/10.22037/ijcn.v14i1.22931
Abstract
Abstract
Objective
Febrile seizure (FS) is the most common seizure disorder in children. FS is a genetic age-limited seizure disorder that occurs only with febrile illness. Nowadays, we know that genetic factors play a major role in occurrence of FS, but some trace elements (for example: zinc) may have important role in occurrence of FS. In this study, we investigate serum level of zinc in patients with FS and in febrile children without seizure as control group.
Materials & Methods
In this case-control prospective study 41 patients with first febrile seizure (FS) (simple & complex) as case group and 41 febrile children without seizure as age, sex matched control group admitted in Besat hospital in Hamadan between January 2013 to January 2014 were enrolled. Ages of children were 6 months to 5 years. Serum zinc levels were measured by atomic absorption spectrophotometery method in these groups.
Results
The mean serum zinc level was 70.41±20.46 mcg/dl and 92.73±17.62 mcg/dl in the case group and the control group, respectively (P = 0.001). In fact, serum zinc level in children with FS was significantly lower than that of control group.
Conclusion
Although based on results of this study, we found lower serum zinc level in children with febrile seizure, but we can't recommend zinc administration for prevention of FS and we need further fundamental basic studies in futures.
- Febrile Seizure
- Zinc
- Trace Element
- Children
How to Cite
References
- Febrile seizures: clinical practice guideline for the long-term management of the child with simple febrile seizures. Pediatrics 2008; 121(6):1281-1286. [PMID:18519501] [doi:10.1542/peds.2008-0939]
- Nasehi MM, Abbaskhanian A, Salehiomran MR. Association between Iron Deficiency Anemia and Febrile Seizure: a Systematic Review and Meta-Analysis, J Pediatr Rev. 2013; 1(2):13-8.
- American Academy of Pediatrics, 2011. Clinical practice guideline: febrile seizures: guideline for the neurodiagnostic evaluation of the child with a simple febrile seizure. Pediatrics. 127, 389–394. [PMID:21285335].[doi: 10.1542/peds.2010-3318]
- Glykys JC, Jones RM. Febrile Seizures. In: B. Sims K, et al. Handbook of Pediatric Neurology. Lippincott Williams & Wilkins Press; 2014.P.50-51. [ Handbook]
- Shinnar S, Seinfeld S. Febrile Seizures. In: Swaiman KF, Ashwal S, Ferriero DM, editors. Pediatric neurology principle & practice. 6th Ed, vol. 1.Elsevier Press; 2017. P. 520-523. [Textbook]
- Namakin K, Zardast M, Sharifzadeh Gh, Bidar T, Zargarian S. Serum Trace Elements in Febrile Seizure: A Case-Control Study. Iran J Child Neurol. Summer 2016; 10(3):57-60. [doi: 10.22037/ijcn.v10i3.9215]
- Frederickson CJ. Neurobiology of zinc and zinc-containing neurons. Int Rev Neurobiol. 1989; 31:145–238. [PMID: 2689380]
- Talebian A, Vakili Z, Talar A, Kazemi M, Mousavi GA. Assessment of the relation between serum zinc and magnesium levels in children with febrile convulsion. Iranian j pathol 2009; 4(4):157-60. [doi: 10.14260/jemds/2014/2233]
- Siamak S, Barzegar M, Zokae N, Shadi S. Does Supplemental Zinc Prevent Recurrence of Febrile Seizures? .Iranian journal of child neurology.2011.Vol 5, No4.p38.
- Salehiomran MR, Mahzari M. Zinc Status in Febrile Seizure. A Case-Control Study. Iran J Child Neurol 2013; 7(4):20-23. [PMCID: PMC3943049]
- Ganesh R, Janakiraman L. Serum Zinc levels in children with simple febrile seizures. Clin Pediatr (Phila) 2008; 47:164–166.[PMID: 17873242]
[Doi: 10.1177/0009922807306165]
- Osama N. Salah, Ehab R. Abdelraou, Marwa H. Abdelhameed Ahmed A, et al. Assessment of the Level of GABA and some trace elements in blood in children who suffer from familial febrile convulsions. Macedonian J Med Sci 2014; 7(1):68-73. [doi: 10.3889/oamjms.2014.012]
- Heydarian F, Ashrafzadeh F, Ghasemian A. Serum zinc level in patients with simple febrile seizure. Iran J Child Neurol 2010; 4(2):41-3. [doi:10.22037/ijcn.v4i2.1869]
- Lee JH, Kim JH. Comparison of serum zinc levels Measured by Inductively Coupled Plasma Mass Spectrometry in Preschool Children with Febrile and Afebrile Seizures. Ann Lab Med 2012; 32(3):190-3. [PMID: 22563553][doi:10.3343/alm.2012.32.3.190]
- Ehsanipour F, Talebi-Taher M, Harandi N, Kani k. Serum zinc level in children with febrile convulsion and its comparison with that of control group. Iranian J Pediatr 2009; 199:65-8. [Short communication]
- Cho WJ, Son BH, Kim SW. Levels of Sodium and Zinc Concentration in febrile convulsion. Korean Child Neural Soc1999; 7(2):214-9.
- Amouian S, Mohammadian S, Behnampour N, Tizrou M. Trace Elements in Febrile Seizure Compared to Febrile Children Admitted to an Academic Hospital in Iran, 2011. J Clin Diagn Res 2013 Oct; 7(10):2231-3.
[Doi: 10.7860/JCDR/2013/5548.3478]
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