Comparison of risk factors related to intraventricular hemorrhage between preterm infants born after normal and in vitro fertilization conceptions, a historical cohort study
Iranian Journal of Child Neurology,
Vol. 13 No. 1 (2019),
1 January 2019
,
Page 71-78
https://doi.org/10.22037/ijcn.v13i1.16655
Abstract
Objectives: Recent studies have shown an association between IVH and in-vitro fertilization (IVF) treatment. Objectives: The purpose of our study was to compare the level of significance of risk factors related IVH between preterm infants born after IVF and non-IVF conceptions. Material and Methods; a historical cohort study was done at 4 Iranian Hospitals in 2013-2014. Based on medical records 155 preterm newborns were divided into case (IVF) and control (normal conception) groups. Both groups' demographic data were extracted and recorded. The incidence of IVH and its' grades were compared between case and control groups. Significant related risk factors were also considered. Results: With regard to demographic characteristics, no differences were observed between 2 groups except for gestational age and mode of delivery (p<.05). The incidence of IVH especially grade II and III were significantly higher in the case group (P = 0.003). Results showed no correlations between GA, birth weight and number of gestations with the incidence of IVH in the case group (0.059, 0.85 and 0.49, respectively).On the other hand among GA, birth weight and number of gestations; multi gestations (p value=0.0001) was an effective risk factor for IVH occurrence in the controls. Conclusion; Results showed that the incidence of IVH in the IVF group was significantly higher than in the non-IVF group. IVF as an independent risk factor may cause high-grade IVH; however, in the controls, multi gestational pregnancy (p value=0.0001) was an effective risk factor for IVH occurrence.
- intraventricular hemorrhage
- in vitro fertilization
- natural conception
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References
References:
Szpecht D, Frydryszak D, Miszczyk N, Szymankiewicz M, Gadzinowski J. The incidence of severe intraventricular hemorrhage based on retrospective analysis of 35939 full-term newborns-report of two cases and review of literature. Childs Nerv Syst. 2016 Jul 8. [Epub ahead of print]
Linder N, Haskin O, Levit O, Klinger G, Prince T, Naor N, et al.Risk Factors for Intraventricular Hemorrhage in Very Low Birth Weight Premature Infants: A Retrospective Case-Control Study. Pediatrics.May 2003, 111(5).590-8
Szpecht D, Frydryszak D, Miszczyk N, Szymankiewicz M, GadzinowskiJ.The incidence of severe intraventricular hemorrhage based on retrospective analysis of 35939 full-term newborns-report of two cases and review of literature. Childs Nerv Syst. 2016 Jul 8. [Epub ahead of print]
Szpecht D, Szymankiewicz M, Nowak I, Gadzinowski J. Intraventricular hemorrhage in neonates born before 32 weeks of gestation—retrospective analysis of risk factors. Childs Nerv Syst.2016; 32: 1399–1404.
Calisici E, Eras Z, Oncel MY, Oguz SS, Gokce İK, DilmenU.Neurodevelopmental outcomes of premature infants with severe intraventricular hemorrhage. J Matern Fetal Neonatal Med. 2015;28(17):2115-20. doi: 10.3109/14767058.2014.979783. Epub 2014 Nov 14.
Jodeiry B, Heidarzadeh M, Sahmani-Asl S, Hoseini M, Javaherizadeh H, Eliasi S, AbediniK.Study of intraventricular hemorrhage in VLBW neonates admitted in Al-Zahra Hospital, Tabriz, Iran. Niger J Med. 2012 Jan-Mar;21(1):92-7.
Kenny JD, Garcia-Prats JA, Hilliard JL, Corbet AJ, Rudolph AJ 1978 Hypercarbia at birth: a possible role in the pathogenesis of intraventricular hemorrhage. Pediatrics62:465–467
Heuchan AM, Evans N, Henderson Smart DJ, Simpson JM. Perinatal risk factors for major intraventricularhaemorrhage in the Australian and New Zealand Neonatal Network, 1995–97. Arch Dis Child Fetal Neonatal Ed 2002;86:F86–F90
Antoniuk S, da Silva RV. Periventricular and intraventricular hemorrhage in the premature infants.Rev Neuro 2000;l31:238–243
Spasojević S, Konstantinidis G, Doronjski A. Morbidity and mortality of premature neonates after introduction of national in vitro fertilisationprogramme--our experience.SrpArhCelokLek. 2010 Jan-Feb;138(1-2):67-71.
Squires J, Kaplan P. Developmental Outcomes of Children Born After Assisted Reproductive Technologies. Infants & Young Children. 2007; 20(1): 2–10c_2007 Lippincott Williams & Wilkins, Inc.
Manoura A, Korakaki E, Hatzidaki E, Bikouvarakis S, Papageorgiou M, GiannakopoulouC.Perinatal outcome of twin pregnancies after in vitro fertilization. ActaObstetGynecol Scand. 2004 Nov;83(11):1079-84.
Turker U, Doger E, Arısoy AE, Günlemez A, Gökalp AS, The effect of IVF pregnancies on mortality and morbidity in tertiary unit Italian Journal of Pediatrics2013;39:17
Tremayne S, Akhondi MM, Conceiving IVF in Iran. Reproductive BioMedicine and Society Online.2016; 2, 62–70 .
Yang H, Choi YS, Nam KH, Kwon JY, Park YW, Kim YH: Obstetric and perinatal outcomes of dichorionic twin pregnancies according to methods of conception: spontaneous versus in-vitro fertilization. Twin Res Hum Genet 2011, 14(1):98–103.
Schieve LA, Meikle SF, Ferre C, Peterson HB, Jeng G, Wilcox LS. Low and very low birth weight in infants conceived with use of assisted reproductive technology. N Engl J Med 2002, 346(10):731–7.
Turkish neonatal society study group on assisted reproductive techniques and multiple pregnancies. Neonatal outcomes assisted reproduction and multiple pregnancies, Ankara, Turkey). Neonatal outcomes assisted reproduction and multiple pregnancies. Çocuk Sağlığıve Hastalıkları Dergisi 2010, 53:258–266.
Ballabh P. Intraventricular Hemorrhage in Premature Infants: Mechanism of Disease. Pediatric Research (2010) 67, 1–8; doi:10.1203/PDR.0b013e3181c1b176
del Moral T, Dominguez S, Kooning K, Vanburskit S. Neonatal outcomes of very preterm infants born after in vitro fertilization. Archdischild 2012; 97(2)302724.1758
Göçmen A, Güven S, BağciS, Çekmez Y, Şanlıkan F. Comparison of maternal and fetal outcomes of IVF and spontaneously conceived twin pregnancies: three year experience of a tertiary hospital. Int J ClinExp Med. 2015; 8(4): 6272–6276. Published online 2015 Apr 15. IJCEM Copyright © 2015.
Luque MJ, Tapia JL, Villarroel L , Marshall G, Musante G , Carlo W, et al. A risk prediction model for severe intraventricular hemorrhage in very low birth weight infants and the effect of prophylactic indomethacin. Journal of Perinatology 2014; 34: 43–48
Shankaran S, Lin A, Maller-Kesselman J, Zhang H, O’Shea TM, Bada H,et al. Maternal race, demography and health care disparities impact risk for IVH in preterm neonates. J Pediatr. 2014 May; 164(5): 1005–1011.e3.
Lee J, Kim HS, Jung E, Kim ES, Shim GH, Joo H, et al. Risk Factors for Periventricular-Intraventricular Hemorrhage in Premature Infants. J Korean Med Sci. 2010 Mar; 25(3): 418–424.
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