Metabolic Screening in Children with Neurodevelopmental Delay, Seizure and/or Regression
Iranian Journal of Child Neurology,
Vol. 11 No. 3 (2017),
3 July 2017
,
Page 42-47
https://doi.org/10.22037/ijcn.v11i3.14321
Abstract
How to Cite This Article: Karimzadeh P, Taghdiri MM, Abasi E, Hassanvand Amouzadeh M, Naghavi Zh, Ghazavi A, Nasehi MM, Alipour A. Metabolic Screening in Children with Neurodevelopmental Delay, Seizure and/or Regression. Iran J Child Neurol. Summer 2017; 11(3):42-47.
Abstract
Objective
Neurometabolic disorder is one of the important groups of diseases that prominently has presentation early infantile period. In this study, we evaluated the result of metabolic screening of the patient with seizure, developmental delay and/or regression in development, demographic disease clinical and radiological findings on admitted and outpatient visited children.
Materials & Methods
Two-year retrospective review of 187 children with seizure, developmental delay and/or regression in the Mofid Children Hospital, Tehran, Iran was performed. The diagnosis was based on observation, findings of EEG and history of the patient, besides evaluation of patient milestones. The result of metabolic screening with Tandem mass spectrometry was evaluated using SPSS (ver.18.0) Statistical software.
Results
Totally, 187 children with seizure, regression and/or developmental delay were evaluated by metabolic screening with tandem mass spectrometry method. The results of laboratory examination had no relationship between positive results of metabolic screening and the mentioned disease. The relations between positive results of metabolic screening and seizure, regression and/or developmental delay were not statistically meaningful.
Conclusion
Positive results of metabolic screening and seizure, regression and/or developmental delay were not statistically meaningful.
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- Seizure
- Developmental delay
- Regression
- Metabolic screening
- Mass spectrometry
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