Gastroenterology and Hepatology from Bed to Bench

Abstract

Inflammatory bowel disease (IBD) is a chronic inflammatory disease affecting the gastrointestinal tract and includes ulcerative colitis and Crohn’s disease. During last decades, the incidence of IBD   has increased, both in children as well as in adults (1–3). While the precise etiology of IBD is unknown, inflammatory bowel disease occure due to an abnormal immune response to luminal antigens in genetically susceptible persons. Uhlig et al ,classified  the diseases into epithelial natural barrier and it’s  response defects in bacterial phagocitosis, disorders in inflammatory process and immune system disorders (such as  low antibody production, neutropenia or immune dysregulation) (4).Although over 160 specific genetic loci have been identified underlying the predisposition but Genome-wide association (GWA) studies are substantially improving our knowledge of the molecular pathways leading to IBD (5).