Gastroenterology and Hepatology from Bed to Bench

Abstract

The prevalence of obesity as one of the most health concerns has increased globally. This kind of disease has been accounted for several diseases such as type 2 diabetes, different types of cancer, heart disease, and Alzheimer. Obesity is a multifactorial disease that both environmental factors and genetics play important role in its susceptibly. In molecular biology, characterization of the adipocyte secretome is important in signaling to other organs and in regulating energy balance for evaluating underlines mechanism. Since better understanding of this disease lead to both preventive and post treatment of obesity which is achieved by molecular evaluations, this review underlies the importance of some molecular approaches in the field of obesity.