Pregnancy outcome in patients with non-alcoholic fatty liver disease: a prospective cohort study
Gastroenterology and Hepatology from Bed to Bench,
Vol. 17 No. 2 (2024),
14 April 2024
https://doi.org/10.22037/ghfbb.v17i2.2896
Abstract
Background: Gaining insights into the impact of non-alcoholic fatty liver disease (NAFLD) on pregnancy outcomes is essential for ensuring the health and well-being of both mothers and infants. Therefore, this study was conducted to investigate potential links between NAFLD during pregnancy and adverse maternal and perinatal outcomes.
Methods: This prospective cohort study, conducted in 2022 at Imam Khomeini and Razi hospitals, compared 180 pregnant women in the NAFLD group to 180 in the control group. We collected background information, medical history, and lab data during their initial visit using a researcher-made checklist. Follow-up continued until one week after delivery, with pregnancy outcomes assessed. Statistical analysis employed Student's t-test and the Chi-Square test for group comparisons.
Results: Significant differences were observed between the NAFLD and control groups in age (P=0.003), BMI (P=0.016), ALT and AST measures (P<0.001), and hypertensive complications (P=0.044). The NAFLD group also had higher rates of gestational diabetes (P<0.001) and gestational hypertension (P=0.003). However, no significant differences were found in gestational age at delivery, early postpartum hemorrhage rates, birth weight, and neonatal Apgar scores (P>0.05).
Conclusion: The pregnant women with NAFLD may be at risk for various complications during pregnancy, including a higher prevalence of gestational diabetes, elevated liver enzymes, and higher blood pressure compared to healthy pregnant women. However, the study did not find significant differences in terms of birth weight, Apgar scores, or neonatal mortality between infants born to mothers with NAFLD and those born to healthy mothers.
- - non-alcoholic fatty liver disease
- diabetes mellitus
- pregnancy
How to Cite
References
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