Transient Non-coeliac gluten sensitivity with markedly reduced villous height/crypt depth
Gastroenterology and Hepatology from Bed to Bench,
Vol. 16 No. 2 (2023),
21 April 2023
https://doi.org/10.22037/ghfbb.v16i2.2755
Abstract
There is no confident evidence in the current literature to show or demonstrate that non-coeliac gluten sensitivity (NCGS) exclusively presents with mild or nearly normal duodenal mucosal abnormality. Gluten sensitive patients with negative serology and severe mucosal changes are labelled with the term seronegative coeliac disease (SNCS). There might be at least some overlap between NCGS and SNCD. Transient gluten sensitivity with severe mucosal changes without CD have been previously reported like in our case.
- Non-coeliac gluten sensitivity
- coeliac disease
- histology
How to Cite
References
2. Rostami K, Ensari A, Marsh MN, et al. Gluten induces subtle histological changes in duodenal mucosa of patients with non-coeliac gluten sensitivity: a multicentre study. Nutrients 2022;14(12):2487.
3. Sapone A, Bai JC, Ciacci C, et al. Spectrum of gluten-related disorders: consensus on new nomenclature and classification. BMC medicine 2012;10(1):1-12.
4. Dore MP, Pes GM, Dettori I, Villanacci V, Manca A, Realdi G. Clinical and genetic profile of patients with seronegative coeliac disease: the natural history and response to gluten-free diet. BMJ Open Gastroenterol 2017;4(1):e000159. (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=28944073).
5. Carroccio A, Giannone G, Mansueto P, et al. Duodenal and Rectal Mucosa Inflammation in Patients With Non-celiac Wheat Sensitivity. Clin Gastroenterol Hepatol 2019;17(4):682-690 e3. (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=30138736).
6. Uhde M, Ajamian M, Caio G, et al. Intestinal cell damage and systemic immune activation in individuals reporting sensitivity to wheat in the absence of coeliac disease. Gut 2016;65(12):1930-1937. (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=27459152).
7. Walker-Smith J. Transient gluten intolerance. Arch Dis Child 1970;45(242):523-6. (In eng). DOI: 10.1136/adc.45.242.523.
8. Berg N, Lindberg T. Incidence of coeliac disease and transient gluten intolerance in children in a Swedish urban community. Acta Pædiatrica 1979;68(4):397-400.
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