Royal jelly Accelerate healing of acetate induced gastric ulcer in male rats
Gastroenterology and Hepatology from Bed to Bench,
Vol. 13 No. 1 (2020),
22 January 2020
,
Page 14-22
https://doi.org/10.22037/ghfbb.v13i1.1714
Abstract
Abstract
Background: Scientific reports suggest that bee products are useful for healing of wounds.
Objective: The healing potential of royal jelly on the acetic acid induced wounds healing in male rat’s gastric mucosa were studied.
Materials: 96 male Wistar rats divided into in 4 groups includes: Control (without treatment), Omeprazole (20 mg/kgw), and Royal jelly (50, 200 mg /kgw). Gastric ulcer was induced in all rats with100% acetic acid. Treatment groups received omeprazole or royal jelly from 1nd to 14th day after acetic ulceration. The histopathological parameters were evaluated on 4, 7, 10,15th days after ulceration.
Results: The administration of royal jelly significantly reduced depth of gastric lesion (p<0.05) and attuned histopathological changes compere to control group. The largest healing effect of royal jelly was on the 10 day of treatment, and at its higher used concentration (200 mg/kg).
Conclusion: These findings supported that royal jelly has valuable effects on Gastric ulcer healing, and can used for peptic ulcer therapy.
- Royal jelly
- Gastric ulcer
- Rat.
How to Cite
References
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