Demographic changes of hepatitis B virus infection in Iran for the last two decades
Gastroenterology and Hepatology from Bed to Bench,
Aim: The objective of this study was to evaluate the impact of the hepatitis B virus (HBV) vaccination program, 24 years after its implementation, by analyzing patients with hepatitis B surface antigen (HBsAg) infection based on gender and age group.
Background: Since the launch of the first universal vaccination program against HBV in Iran in 1993, the epidemiological pattern of HBV prevalence may have changed in our country.
Methods: All data for this cross-sectional study were collected from medical records of HBsAg positive patients, who were referred to the Golhak and Armin private laboratories and also to the Gastrointestinal Department of Tehran’s Taleghani Hospital and Day Hospital in Iran over a period of 5 years (2011-2016). In total, 8,606 HBsAg positive subjects were assessed according to gender and age group.
Results: The rates of HBsAg carriage were 0.8%, 7.8%, 49.3%, 27.9% and 14.1% among subjects under 14 years old, 15-24 years, 25-44 years, 45-59 years and those older than 60 years, respectively. According to the age subgroup analyses; the highest (26.2%) and lowest (0.6%) rate of HBsAg positivity was seen in the 31-40 age group and younger than 10 year old children, respectively.
Conclusion: Global vaccination against hepatitis B has significantly reduced carrier rates among children and teenagers under 20 years old in this country. Nevertheless, HBsAg carriers still remain highly prevalent among 25-35-year age group. Therefore, the decline is limited to the younger population born after 1993, and it remains high in the middle-aged individuals
- Hepatitis B virus
- hepatitis B surface antigen (HBsAg)
How to Cite
Schweitzer A, Horn J, Mikolajczyk RT, Krause G, Ott JJ. Estimations of worldwide prevalence of chronic hepatitis B virus infection: a systematic review of data published between 1965 and 2013. Lancet 2015;386:1546-55.
Ashtari S, Pourhoseingholi MA, Sharifian A, Zali MR. Hepatocellular carcinoma in Asia: Prevention strategy and planning. World journal of hepatology 2015;7:1708-17.
Pourhoseingholi MA, Fazeli Z, Zali MR, Alavian SM. Burden of hepatocellular carcinoma in Iran; Bayesian projection and trend analysis. Asian Pacific journal of cancer prevention : APJCP 2010;11:859-62.
Fazeli Z, Pourhoseingholi MA, Vahedi M, zali MR. Burden of Hepatocellular Carcinoma in Asia. Asian Pacific Organization for Cancer Prevetion 2012;13:5955-8.
Rostami K, Malekzadeh R, Shahbazkhani B, Akbari MR, Catassi C. Coeliac disease in Middle Eastern countries: a challenge for the evolutionary history of this complex disorder? Dig Liver Dis 2004;36:694-7.
Merican I, Guan R, Amarapuka D, Alexander MJ, Chutaputti A, Chien RN, et al. Chronic hepatitis B virus infection in Asian countries. Journal of gastroenterology and hepatology 2000;15:1356-61.
Ott JJ, Stevens GA, Groeger J, Wiersma ST. Global epidemiology of hepatitis B virus infection: new estimates of age-specific HBsAg seroprevalence and endemicity. Vaccine 2012;30:2212-9.
Peña AS, Rodrigo L. Epidemiology of Celiac Disease and Non-celiac Gluten-Related Disorders. In Arranz E, Fernández-Bañares F, Rosell CM, Rodrigo L, Peña AS, editors. Advances in the Understanding of Gluten Related Pathology and the Evolution of Gluten-Free Foods. Barcelona, Spain: OmniaScience; 2015:27-73.
Mast EE, Margolis HS, Fiore AE, Brink EW, Goldstein ST, Wang SA, et al. A comprehensive immunization strategy to eliminate transmission of hepatitis B virus infection in the United States: recommendations of the Advisory Committee on Immunization Practices (ACIP) part 1: immunization of infants, children, and adolescents. MMWR Recommendations and reports : Morbidity and mortality weekly report Recommendations and reports 2005;54:1-31.
Mohammadi Z, Keshtkar A, Eghtesad S, Jeddian A, Pourfatholah AA, Maghsudlu M, et al. Epidemiological Profile of Hepatitis B Virus Infection in Iran in the Past 25 years; A Systematic Review and Meta-analysis of General Population Studies. Middle East J Dig Dis 2016;8:5-18.
Shakeri MT, Foghanian B, Nomani H, Ghayour-Mobarhan M, Nabavinia MS, Rostami S, et al. The prevalence of hepatitis B virus infection in mashhad, iran: a population-based study. Iran Red Crescent Med J 2013;15:245-8.
Salehi M, Alavian SM, Tabatabaei SV, Izadi S, Sanei Moghaddam E, Amini Kafi-Abad S, et al. Seroepidemiology of HBV infection in South-East of iran; a population based study. Iran Red Crescent Med J 2012;14:283-8.
Alavian SM. Ministry of Health in Iran is serious about controlling hepatitis B. Hepatitis monthly 2007;7:3-5.
Alavian SM, Fallahian F, Lankarani KB. The changing epidemiology of viral hepatitis B in Iran. Journal of gastrointestinal and liver diseases : JGLD 2007;16:403-6.
Zali MR, Mohaghegh Shalmani H. The changing epidemiology of hepatitis B in Iran. Gastroenterology and Hepatology From Bed to Bench 2010;3:1-4.
Zali MR, Mohammad K, Noorbala AA, Noorimayer B, Shahraz S. Rate of hepatitis B seropositivity following mass vaccination in the Islamic Republic of Iran. Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit 2005;11:62-7.
Alavian SM. Hepatitis B virus infection in Iran; Changing the epidemiology. Iranian Journal of Clinical Infectious Diseases 2010;5:51-61.
Sood A, Midha V, Sood N, Avasthi G, Sehgal A. Prevalence of celiac disease among school children in Punjab, North India. J Gastroenterol Hepatol 2006;21:1622-5.
Ott MJ, Aruda M. Hepatitis B vaccine. Journal of pediatric health care : official publication of National Association of Pediatric Nurse Associates & Practitioners 1999;13:211-6.
Mirrezaie SM, Saber HR, Hajibeigi B, Salekmoghaddam E, Abbasian A, Alavian SM. Impact of HBV Vaccination on Prevalence of Hepatitis B Virus Infection Among Volunteer Blood Donors in Tehran-Iran. Shiraz E-Med J 2014;15:e18066.
Mackie CO, Buxton JA, Tadwalkar S, Patrick DM. Hepatitis B immunization strategies: timing is everything. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 2009;180:196-202.
Poorolajal J, Majdzadeh R. Prevalence of chronic hepatitis B infection in Iran: a review article. Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences 2009;14:249-58.
Janahi EM. Prevalence and risk factors of hepatitis B virus infection in Bahrain, 2000 through 2010. PloS one 2014;9:e87599.
Alavian SM, Tabatabaei SV, Ghadimi T, Beedrapour F, Kafi-Abad SA, Gharehbaghian A, et al. Seroprevalence of Hepatitis B Virus Infection and Its Risk Factors in the West of Iran: A Population-based Study. International journal of preventive medicine 2012;3:770-5.
Liao SS, Li RC, Li H, Yang JY, Zeng XJ, Gong J, et al. Long-term efficacy of plasma-derived hepatitis B vaccine: a 15-year follow-up study among Chinese children. Vaccine 1999;17:2661-6.
Azami M, Hafezi-Ahmadi MR, Sayehmiri K. Hepatitis B Vaccination Efficacy in Iranian HealthcareWorkers: A Meta-Analysis Study. Hepatitis monthly 2017;17:e37781.
Sayehmiri K, Azami M, Nikpey S, Borji M, Sayehmiri F. Hepatitis B Vaccination Coverage in Health Personnel of Iran: A Systematic Review and Meta-Analysis Study. Iran J Epidemiol 2015;11:1-10.
Azami M, Sayehmiri K, Darvishi Z, Sayehmiri F. Hepatitis B vaccination coverage among dentists in Iran: a systematic review and metaanalysis study. Hepatitis monthly 2015;15:37.
Azami M, Borji M, Ghanbari F, Nikpay S, Sayehmiri K. Hepatitis B vaccination coverage of physicians and nurses in Iran: a systematic review and meta-analysis study. J Birjand Univ Med Sci 2015;22:304-15.
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