Validation of a method to assess occupational exposure to tert-buthyl mercaptan by gas chromatography- mass spectrometry (GC-MS)
Journal of Health in the Field,
,
20 March 2020
چکیده
Background and Aims: Tert-butyl mercaptan is used as an important odorant of natural gas. Exposure to high concentrations of this substance lead to stimulating effects in human. Occupational exposure to mercaptan is measured by gas chromatography - flame photometer according to NIOSH 2542. The purpose of this study was to develop a method for sampling and analyzing tert-butyl mercaptan using GC_MS.
Materials and Methods: In this study, tert-butyl mercaptan was analyzed using BP-5 MS column and internal standard of 4-methyl thiophenol. Calibration curve was developed and evaluated in the range of 0.45-10 ppm. Repeatability of method was presented by inter- day and intra-day assay based on the coefficient of variation (CV). Recovery of tert-butyl mercaptan was reported as the accuracy of method. All procedures of this study were approved by Shahid beheshti University of medical Science Institutional Review Board.
Results: Retention Time of tert-butyl mercaptan and 4-methylthiophenol were determined as 4.05 and 8.01 min, respectively. Calibration curve was evaluated by the regression of 0.99. The mean recovery percent was 98.68 ± 6.6. Intra-day and inter-day coefficient of variance for standard concentrations was ranged between 0.46-7.2 percent. The limit of detection and limit of quantitation were presented 0.037 and 1.84 μg/sample, respectively.
Conclusion: GC-MS method by validated parameters was suggested as a suitable alternative for NIOSH method.
مراجع
- Jain P, Kushwaha R, editors. Wireless gas sensor network for detection and monitoring of harmful gases in utility areas and industries. Proceedings of the Sixth International Conference on Sensing Technology (ICST) 2012 Dec. 18-21; Kolkata, India.
- Yang Y, Wang Z, Zong B, Yang H. Determination of sulfur compounds in fluid catalytic cracking gasoline by gas chromatography with a sulfur chemiluminescence detector. Chinese Journal of Chromatography 2004; 22(3):216-19.
- Babaei Nasami F. Appropriate methods for eliminating the smell of mercaptan barrels and their effects on the environment [dissertation]. School of Basic Sciences: Payam-e-nour UniversityOf Mazandaran Province; 2008 (In Persian).
- Kopasz JP. Fuel cells and odorants for hydrogen. International Journal of Hydrogen Energy 2007; 32(13):2527-31.
- Zeiny ARN. Gas Sealing in Pem Fuel Cells. 2014. DOI:10.13140/RG.2.1.4541.2560
- Abraham MH, Gola JM, Cometto-Muniz JE. An assessment of air quality reflecting the chemosensory irritation impact of mixtures of volatile organic compounds. Environment international 2016; 86:84-91.
- Szczurek A, Maciejewska M, Flisowska-Wiercik B, Bodzoj Ł. Application of a sensor system for determining the kind and quantity of two component VOC mixtures in air after the use of solvents. Journal of Environmental Monitoring 2009; 11(11):1942-51.
- NIOSH. NIOSH Manual of Analytical Methods. 5th ed. Washington, D.C: Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health 2017.
- Chin S-T, Wu Z-Y, Morrison PD, Marriott PJ. Observations on comprehensive two dimensional gas chromatography coupled with flame photometric detection for sulfur-and phosphorus-containing compounds. Analytical Methods 2010; 2(3):243-53.
- Turpin A, Couvert A, Laplanche A, Paillier A. Mass transfer and deodorization efficiency in a countercurrent spray tower for low superficial gas velocities. The Canadian Journal of Chemical Engineering 2009; 87(1):53-59.
- Kelly LC, Rawson P. Detection and identification of sulfur compounds in an Australian jet fuel. Australia: Australian Government, Defence Science and Technology Organisation, 2010.
- Lee I, Ubanyionwu H. Determination of sulfur contaminants in military jet fuels. Fuel 2008; 87(3):312-18.
- Hosseini, V. Occupational exposure evaluation of shoe makers to benzene and toluene compounds in the manufacturing workshops in East Tehran [dissertation]. School of Health and Safety: Shahid Beheshti University Of Medical Sciences; 2012 (In Persian).
- Keleş D, Taşkın H, Baktemur G, Kafkas E, Büyükalaca S. Comparitive study on volatile aroma compounds of two different garlic types (Kastamonu and Chinese) using gas chromatography mass spectrometry (HS-GC/MS) technique. African Journal of Traditional, Complementary and Alternative Medicines 2014; 11(3):217-20.
- Myung S-W, Huh S, Kim J, Kim Y, Kim M, Kim Y, et al. Gas chromatographic–mass spectrometric analysis of mercaptan odorants in liquefied petroleum gas and liquefied natural gas. Journal of Chromatography A 1997; 791(1-2):367-70.
- Imanishi H, Takahashi T. The new quantitative analytical method for ultratrace sulfur compounds in natural gas. Proceedings of the International Gas Union Research Conference 2014 Sep. 17-19; Copenhagen, Denmark.
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