Genetic Footprints of Human Papilloma Virus in Ocular Surface Squamous Neoplasia
Journal of Ophthalmic and Optometric Sciences,
Vol. 4 No. 3 (2020),
23 June 2020
,
Page 54-69
https://doi.org/10.22037/joos.v4i3.38970
Abstract
Ocular surface squamous neoplasia (OSSN) after melanoma and lymphoma is the third most common tumor. Including a wide range of ocular malignancy from mild form of epithelial abnormality to invasive squamous cell carcinoma (SCC). Overall, the lesions are different in size but mostly occur in specific tissue called limbus due to the structure of the eye ball, that is the most common area for sunlight exposing. Beside exposure to the sunlight and the UV radiation there are other risk factors and genetic co factors related to the OSSN including immune suppression under the infection to the Human immunodeficiency virus (HIV) or Human papilloma virus (HPV) and also mutation in specific genes regulating cell cycles. However, the exact relation between many of these factors and OSSN has not been revealed and need further researches in this area.
In this review we aimed to study OSSN from different views specially risk factors and a glimpse of genetic insights specially related to human viral genome. Later, categorizing the role of them to pave the way in answering different questions related to the OSSN among types of that. On the other hand, although there is no evidence for straight relation between p53 mutations in OSSN, here we tried to mention the separated pathway’s role in p53 malfunction or disabled in different process leading to cancers namely OSSN.
Keywords:
- Human Immunodeficiency Virus
- Human Papilloma Virus
- ; Ocular Surface Squamous Neoplasia
- p53 Gene
- Squamous Carcinoma
How to Cite
Ghaffarian Zavarzadeh, P. ., Yaghooti, Y., & Daryabari, S.-H. . (2020). Genetic Footprints of Human Papilloma Virus in Ocular Surface Squamous Neoplasia . Journal of Ophthalmic and Optometric Sciences, 4(3), 54–69. https://doi.org/10.22037/joos.v4i3.38970
References
1. Cicinelli MV, Marchese A, Bandello F, Modorati G. Clinical Management of Ocular Surface Squamous Neoplasia: A Review of the Current Evidence. Ophthalmol Ther. 2018;7(2):247-62.
2. Al Bayyat G, Arreaza-Kaufman D, Venkateswaran N, Galor A, Karp CL. Update on pharmacotherapy for ocular surface squamous neoplasia. Eye Vis (Lond). 2019;6:24-.
3. Fasina O. Ocular surface squamous neoplasia at a tertiary eye facility, Southwestern Nigeria: a 10-year review. Int Ophthalmol. 2021;41(10):3325-31.
4. Gichuhi S, Sagoo MS, Weiss HA, Burton MJ. Epidemiology of ocular surface squamous neoplasia in Africa. Trop Med Int Health. 2013;18(12):1424-43.
5. Sharma R, Sharma K, Chopra P. Limited resection for limbal dysplasia by conjunctivectomy and medial canthectomy for limbal carcinoma involving medial canthus-case series. International Journal of Ocular Oncology and Oculoplasty, January-March, 2017;3(1):73-75. 2017;3:73-5.
6. Ma IH, Hu F-R, Wang IJ, Chen W-L, Hsu Y-J, Chu H-S, et al. Clinicopathologic correlation of ocular surface squamous neoplasia from a university hospital in North Taiwan 1994 to 2014. Journal of the Formosan Medical Association. 2019;118(4):776-82.
7. Rathi SG, Ganguly Kapoor A, Kaliki S. Ocular surface squamous neoplasia in HIV-infected patients: current perspectives. HIV AIDS (Auckl). 2018;10:33-45.
8. Gichuhi S, Ohnuma S-i, Sagoo MS, Burton MJ. Pathophysiology of ocular surface squamous neoplasia. Exp Eye Res. 2014;129:172-82.
9. Di Girolamo N. Association of human papilloma virus with pterygia and ocular-surface squamous neoplasia. Eye. 2012;26(2):202-11.
10. Weinstein JE, Karp CL. Ocular surface neoplasias and human immunodeficiency virus infection. Current Opinion in Infectious Diseases. 2013;26(1).
11. Delic NC, Lyons JG, Di Girolamo N, Halliday GM. Damaging Effects of Ultraviolet Radiation on the Cornea. Photochem Photobiol. 2017;93(4):920-9.
12. Di Girolamo N, Atik A, McCluskey PJ, Wakefield D. Matrix Metalloproteinases and Their Inhibitors in Squamous Cell Carcinoma of the Conjunctiva. The Ocular Surface. 2013;11(3):193-205.
13. Dou L, Wang J, Deng R, Wang C, Xie Z, Yong W. Over-expression of human PP5 gene in mice induces corneal hyperplasia and leads to ocular surface squamous neoplasia. Biochemical and Biophysical Research Communications. 2020;529(2):487-93.
14. Ramos-Betancourt N, Field MG, Davila-Alquisiras JH, Karp CL, Hernández-Zimbrón LF, García-Vázquez R, et al. Whole exome profiling and mutational analysis of Ocular Surface Squamous Neoplasia. The ocular surface. 2020;18(4):627-32.
15. Mantovani F, Collavin L, Del Sal G. Mutant p53 as a guardian of the cancer cell. Cell Death Differ. 2019;26(2):199-212.
16. Kalamkar C, Radke N, Mukherjee A, Radke S. Xeroderma pigmentosum with bilateral ocular surface squamous neoplasia and review of the literature. BMJ Case Rep. 2016;2016:bcr2016215364.
17. Delic NC, Lyons JG, Di Girolamo N, Halliday GM. Damaging Effects of Ultraviolet Radiation on the Cornea. Photochemistry and Photobiology. 2017;93(4):920-9.
18. de Koning MNC, Waddell K, Magyezi J, Purdie K, Proby C, Harwood C, et al. Genital and cutaneous human papillomavirus (HPV) types in relation to conjunctival squamous cell neoplasia: A case-control study in Uganda. Infectious Agents and Cancer. 2008;3(1):12.
19. Luo J, Jing D, Kozak I, Huiming Z, Siying C, Yezhen Y, et al. Prevalence of ocular manifestations of HIV/AIDS in the highly active antiretroviral therapy (HAART) era: a different spectrum in Central South China. Ophthalmic Epidemiol. 2013;20(3):170-5.
20. Chalkia AK, Bontzos G, Spandidos DA, Detorakis ET. Human papillomavirus infection and ocular surface disease (Review). Int J Oncol. 2019;54(5):1503-10.
21. Simbiri KO, Murakami M, Feldman M, Steenhoff AP, Nkomazana O, Bisson G, et al. Multiple oncogenic viruses identified in Ocular surface squamous neoplasia in HIV-1 patients. Infectious Agents and Cancer. 2010;5(1):6.
22. Thomas M, Pim D, Banks L. The role of the E6-p53 interaction in the molecular pathogenesis of HPV. Oncogene. 1999;18(53):7690-700.
23. Carreira H, Coutinho F, Carrilho C, Lunet N. HIV and HPV infections and ocular surface squamous neoplasia: systematic review and meta-analysis. Br J Cancer. 2013;109(7):1981-8.
24. Chauhan S, Sen S, Sharma A, Dar L, Kashyap S, Kumar P, et al. Human papillomavirus: a predictor of better survival in ocular surface squamous neoplasia patients. British Journal of Ophthalmology. 2012;96(12):1517.
25. Nagaiah G, Stotler C, Orem J, Mwanda WO, Remick SC. Ocular surface squamous neoplasia in patients with HIV infection in sub-Saharan Africa. Curr Opin Oncol. 2010;22(5):437-42.
26. Basti S, Macsai MS. Ocular surface squamous neoplasia: a review. Cornea. 2003;22(7):687-704.
27. Zhang KY, Aurit S, Silberstein P. Racial and socioeconomic disparities in ocular surface squamous neoplasia: a National Cancer Database analysis. Ophthalmic Epidemiol. 2021:1-9.
28. Senturk E, Manfredi JJ. p53 and cell cycle effects after DNA damage. Methods Mol Biol. 2013;962:49-61.
29. El-Mofty SK, Zhang MQ, Davila RM. Histologic identification of human papillomavirus (HPV)-related squamous cell carcinoma in cervical lymph nodes: a reliable predictor of the site of an occult head and neck primary carcinoma. Head Neck Pathol. 2008;2(3):163-8.
30. Carrilho C, Miu C, Kim Y, Karki S, Balmaceda A, Challa B, et al. p16 Expression Correlates with Invasive Ocular Surface Squamous Neoplasms in HIV-Infected Mozambicans. Ocular Oncology and Pathology. 2020;6(2):123-8.
31. Sayed-Ahmed IO, Palioura S, Galor A, Karp CL. Diagnosis and Medical Management of Ocular Surface Squamous Neoplasia. Expert Rev Ophthalmol. 2017;12(1):11-9.
32. Shen Y-S, Hu JL, Hu C-C. Anterior high-resolution OCT in the diagnosis and management of corneal squamous hyperplasia mimicking a malignancy: a case report. BMC Ophthalmology. 2019;19(1):235.
33. Al Bayyat G, Arreaza-Kaufman D, Venkateswaran N, Galor A, Karp CL. Update on pharmacotherapy for ocular surface squamous neoplasia. Eye and Vision. 2019;6(1):24.
34. Longley DB, Harkin DP, Johnston PG. 5-Fluorouracil: mechanisms of action and clinical strategies. Nature Reviews Cancer. 2003;3(5):330-8.
2. Al Bayyat G, Arreaza-Kaufman D, Venkateswaran N, Galor A, Karp CL. Update on pharmacotherapy for ocular surface squamous neoplasia. Eye Vis (Lond). 2019;6:24-.
3. Fasina O. Ocular surface squamous neoplasia at a tertiary eye facility, Southwestern Nigeria: a 10-year review. Int Ophthalmol. 2021;41(10):3325-31.
4. Gichuhi S, Sagoo MS, Weiss HA, Burton MJ. Epidemiology of ocular surface squamous neoplasia in Africa. Trop Med Int Health. 2013;18(12):1424-43.
5. Sharma R, Sharma K, Chopra P. Limited resection for limbal dysplasia by conjunctivectomy and medial canthectomy for limbal carcinoma involving medial canthus-case series. International Journal of Ocular Oncology and Oculoplasty, January-March, 2017;3(1):73-75. 2017;3:73-5.
6. Ma IH, Hu F-R, Wang IJ, Chen W-L, Hsu Y-J, Chu H-S, et al. Clinicopathologic correlation of ocular surface squamous neoplasia from a university hospital in North Taiwan 1994 to 2014. Journal of the Formosan Medical Association. 2019;118(4):776-82.
7. Rathi SG, Ganguly Kapoor A, Kaliki S. Ocular surface squamous neoplasia in HIV-infected patients: current perspectives. HIV AIDS (Auckl). 2018;10:33-45.
8. Gichuhi S, Ohnuma S-i, Sagoo MS, Burton MJ. Pathophysiology of ocular surface squamous neoplasia. Exp Eye Res. 2014;129:172-82.
9. Di Girolamo N. Association of human papilloma virus with pterygia and ocular-surface squamous neoplasia. Eye. 2012;26(2):202-11.
10. Weinstein JE, Karp CL. Ocular surface neoplasias and human immunodeficiency virus infection. Current Opinion in Infectious Diseases. 2013;26(1).
11. Delic NC, Lyons JG, Di Girolamo N, Halliday GM. Damaging Effects of Ultraviolet Radiation on the Cornea. Photochem Photobiol. 2017;93(4):920-9.
12. Di Girolamo N, Atik A, McCluskey PJ, Wakefield D. Matrix Metalloproteinases and Their Inhibitors in Squamous Cell Carcinoma of the Conjunctiva. The Ocular Surface. 2013;11(3):193-205.
13. Dou L, Wang J, Deng R, Wang C, Xie Z, Yong W. Over-expression of human PP5 gene in mice induces corneal hyperplasia and leads to ocular surface squamous neoplasia. Biochemical and Biophysical Research Communications. 2020;529(2):487-93.
14. Ramos-Betancourt N, Field MG, Davila-Alquisiras JH, Karp CL, Hernández-Zimbrón LF, García-Vázquez R, et al. Whole exome profiling and mutational analysis of Ocular Surface Squamous Neoplasia. The ocular surface. 2020;18(4):627-32.
15. Mantovani F, Collavin L, Del Sal G. Mutant p53 as a guardian of the cancer cell. Cell Death Differ. 2019;26(2):199-212.
16. Kalamkar C, Radke N, Mukherjee A, Radke S. Xeroderma pigmentosum with bilateral ocular surface squamous neoplasia and review of the literature. BMJ Case Rep. 2016;2016:bcr2016215364.
17. Delic NC, Lyons JG, Di Girolamo N, Halliday GM. Damaging Effects of Ultraviolet Radiation on the Cornea. Photochemistry and Photobiology. 2017;93(4):920-9.
18. de Koning MNC, Waddell K, Magyezi J, Purdie K, Proby C, Harwood C, et al. Genital and cutaneous human papillomavirus (HPV) types in relation to conjunctival squamous cell neoplasia: A case-control study in Uganda. Infectious Agents and Cancer. 2008;3(1):12.
19. Luo J, Jing D, Kozak I, Huiming Z, Siying C, Yezhen Y, et al. Prevalence of ocular manifestations of HIV/AIDS in the highly active antiretroviral therapy (HAART) era: a different spectrum in Central South China. Ophthalmic Epidemiol. 2013;20(3):170-5.
20. Chalkia AK, Bontzos G, Spandidos DA, Detorakis ET. Human papillomavirus infection and ocular surface disease (Review). Int J Oncol. 2019;54(5):1503-10.
21. Simbiri KO, Murakami M, Feldman M, Steenhoff AP, Nkomazana O, Bisson G, et al. Multiple oncogenic viruses identified in Ocular surface squamous neoplasia in HIV-1 patients. Infectious Agents and Cancer. 2010;5(1):6.
22. Thomas M, Pim D, Banks L. The role of the E6-p53 interaction in the molecular pathogenesis of HPV. Oncogene. 1999;18(53):7690-700.
23. Carreira H, Coutinho F, Carrilho C, Lunet N. HIV and HPV infections and ocular surface squamous neoplasia: systematic review and meta-analysis. Br J Cancer. 2013;109(7):1981-8.
24. Chauhan S, Sen S, Sharma A, Dar L, Kashyap S, Kumar P, et al. Human papillomavirus: a predictor of better survival in ocular surface squamous neoplasia patients. British Journal of Ophthalmology. 2012;96(12):1517.
25. Nagaiah G, Stotler C, Orem J, Mwanda WO, Remick SC. Ocular surface squamous neoplasia in patients with HIV infection in sub-Saharan Africa. Curr Opin Oncol. 2010;22(5):437-42.
26. Basti S, Macsai MS. Ocular surface squamous neoplasia: a review. Cornea. 2003;22(7):687-704.
27. Zhang KY, Aurit S, Silberstein P. Racial and socioeconomic disparities in ocular surface squamous neoplasia: a National Cancer Database analysis. Ophthalmic Epidemiol. 2021:1-9.
28. Senturk E, Manfredi JJ. p53 and cell cycle effects after DNA damage. Methods Mol Biol. 2013;962:49-61.
29. El-Mofty SK, Zhang MQ, Davila RM. Histologic identification of human papillomavirus (HPV)-related squamous cell carcinoma in cervical lymph nodes: a reliable predictor of the site of an occult head and neck primary carcinoma. Head Neck Pathol. 2008;2(3):163-8.
30. Carrilho C, Miu C, Kim Y, Karki S, Balmaceda A, Challa B, et al. p16 Expression Correlates with Invasive Ocular Surface Squamous Neoplasms in HIV-Infected Mozambicans. Ocular Oncology and Pathology. 2020;6(2):123-8.
31. Sayed-Ahmed IO, Palioura S, Galor A, Karp CL. Diagnosis and Medical Management of Ocular Surface Squamous Neoplasia. Expert Rev Ophthalmol. 2017;12(1):11-9.
32. Shen Y-S, Hu JL, Hu C-C. Anterior high-resolution OCT in the diagnosis and management of corneal squamous hyperplasia mimicking a malignancy: a case report. BMC Ophthalmology. 2019;19(1):235.
33. Al Bayyat G, Arreaza-Kaufman D, Venkateswaran N, Galor A, Karp CL. Update on pharmacotherapy for ocular surface squamous neoplasia. Eye and Vision. 2019;6(1):24.
34. Longley DB, Harkin DP, Johnston PG. 5-Fluorouracil: mechanisms of action and clinical strategies. Nature Reviews Cancer. 2003;3(5):330-8.
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