Journal of Ophthalmic and Optometric Sciences

Vol. 3 No. 4 (2019)

Probable Toxic Effect of Sodium Valproate on Retine Using Electroretinogram

Journal of Ophthalmic and Optometric Sciences, Vol. 3 No. 4 (2019), 5 October 2019 , Page 24-28
https://doi.org/10.22037/joos.v3i4.36745

Abstract

Aim:

Sodium Valporate (SV) is an anticonvulsant drug which is approved for use in epilepsy and bipolar disorder. It has also been used for neuropathic pain and migraine prophylaxis. It is reported that the drug has different side effect on different organs of the human body. The aim of present work is to search for the probable adverse effect of this drug on retina using Electroretinography (ERG) technique.

Method:

Twenty-five patients taking sodium valproate for 3 years were taken in to consideration for the purpose of recent work. Electroretinography was recorded in patients’ group. Flash ERG was the type of ERG used for this study. Latency (msec) and amplitude (µV) of ERG b wave was measured for each patient. Mean and standard deviation was calculated for patients group. The same procedure was repeated for 25 healthy population.

The findings obtained in two groups were compared together using SPSS version 13 to look for probable differences in two groups.

Result:

The mean latencies/S.D. and amplitude s/ S.D were 90.7 ± 9.39 and 114.94 ± 8.28 in patient and healthy groups, respectively. The difference in amplitude between two groups were statistically significant whereas the difference in latency was not statistically significant.

Conclusion:

Based on findings of recent work it is obvious that retina affected in SV consuming patients after three years which will be discussed in full paper.

Keywords:
  • Sodium Valproate
  • Retina
  • Electroretinogram

How to Cite

Shushtarian, S. M. M., & Hayti, Z. . (2019). Probable Toxic Effect of Sodium Valproate on Retine Using Electroretinogram. Journal of Ophthalmic and Optometric Sciences, 3(4), 24–28. https://doi.org/10.22037/joos.v3i4.36745

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