Cytosolic HMGB1 Expression in Human Renal Clear Cell Cancer Indicates Higher Pathological T Classifications and Tumor Grades
Urology Journal,
Vol. 10 No. 3 (2013),
26 September 2013
,
Page 960-965
https://doi.org/10.22037/uj.v10i3.1425
Abstract
Purpose: High mobility group box (HMGB) proteins are nuclear nonhistone chromosomalproteins that bend DNA, bind preferentially to distorted DNA structures, and promote the assembly
of site-specific DNA binding proteins. Recent reports indicate that HMGB1 functions
as a proinflammatory cytokine. Here, we studied expressions of HMGB1 and HMGB2 in human
renal cancer.
Material and Methods: Immunohistological expressions of HMGB1 and HMGB2 were assessed
in 39 surgically resected human renal cancer specimens.
Results: HMGB1 was expressed in the nucleus in 37 out of 39 (94.9%) renal clear cell cancers,
while its expression in the cytosol was noted in 19 cases (48.7%). Cytosolic HMGB1 is
expressed more frequently in cancers beyond the pT1b classification than in those at the pT1a
classification. Higher tumor grades (≥ G2) were also significantly linked with the cytosolic
expression of HMGB1. HMGB2 was expressed in the nucleus in 35 of 39 (89.7%) renal clear
cell cancers, while its expression in the cytosol was observed in only 7 case (17.9%). Linkage
between cytosolic expression of HMGB2 and T classifications was weakly observed, while that
between nuclear expression and T classifications was not.
Conclusion: HMGB1 expressed in the cytoplasm may be an effective marker indicating higher
T classifications and tumor grades.
How to Cite
Takeuchi, T., Sakazume, K., Tonooka, A., Zaitsu, M., Takeshima, Y., Mikami, K., & Uekusa, T. (2013). Cytosolic HMGB1 Expression in Human Renal Clear Cell Cancer Indicates Higher Pathological T Classifications and Tumor Grades. Urology Journal, 10(3), 960–965. https://doi.org/10.22037/uj.v10i3.1425
- Abstract Viewed: 262 times
- PDF Downloaded: 189 times