A comparative study of influence of isoflurane and propofol on IL1, IL6, TNF serum levels after craniotomy for supratentorial brain tumors
Journal of Cellular & Molecular Anesthesia,
Vol. 4 No. 1 (2019),
15 August 2019
,
Page 8-14
https://doi.org/10.22037/jcma.v4i1.25315
Abstract
Background: The purpose of this randomized, single-center study was to prospectively investigate the impact of anesthetic techniques for craniotomy on the release of cytokines (interleukin (IL)-1, IL-6, tumor necrosis factor factor-alpha (TNF-α)) and to determine whether intravenous anesthesia compared to inhalational anesthesia attenuates the inflammatory response.Methods and Materials: The study enrolled 60 patients undergoing craniotomy, allocated into two equal groups to receive either Isoflurane (n=30) and Propofol (n=30). Non-invasive hemodynamic monitoring was used. Serum levels of IL-1, IL-6 and TNF-α were evaluated before and at the end of surgery and anesthesia.Results: Although there was a significant rise in serum level of inflammatory cytokine but compared with patients anaesthetized with Isoflurane, patients who received Propofol had significant lower levels of IL-1, IL-6 and TNF-a after surgery (p<0.05).Conclusion: Patients who received Propofol had lower levels of IL-1, IL-6 and TNF-α after surgery. Our findings should incite future studies to prove a potential medically important anti-inflammatory role of Propofol in neuroanesthesia.- Craniotomy
- Propofol
- Isoflurane
- Interleukin 1
- Interleukin 6
- TNF-a
How to Cite
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