Thyroid Function Tests and the Serum Levels of Prolactin in Women With Suicide Attempt

Farnaz Rahmani, Farzad Rahmani, Mitra Niafar, Ali Ostadi, Navideh Robai, Fariba Abdollahi, Samira Asadollahi

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Abstract

Background: Suicide is a major public health concern across the world. Based on related studies, thyroid dysfunction is associated with psychiatric disorders. This study aimed to determine the relationship between thyroid function tests and serum prolactin in women with suicide attempt.
Methods: A total of 261 women with the suicide attempt were included in this descriptive-analytical study which took over one year (July 2015- July 2016). In addition, the patients’ serum Thyroid-Stimulating Hormone (TSH), free T4, and prolactin were measured, too.
Results: Of 261 patients, 44(16.9%) had subclinical hypothyroidism, 3(1.1%) clinical hypothyroidism, and 1(0.4%) hyperthyroidism. The median value of serum prolactin in the patients with decreased thyroid function was higher. There were not significant relationship between suicide attempts and thyroid dysfunction or serum level of prolactin.
Conclusion: Although there was no significant relationship between thyroid test, serum level of prolactin and suicide attempts, the prevalence of thyroid dysfunction and high serum levels of prolactin were clinically significant in women who attempted suicide. Thus, the measurement of serum TSH, free T4 and serum levels of prolactin could be considered for these patients.

Keywords

Suicide, Women, Hypothyroidism, Thyroid-stimulating hormone, Prolactin

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References

Amini P, Ahmadinia H, Poorolajal J, Moqaddasi Amiri M. Evaluating the high risk groups for suicide: A comparison of logistic regression, support vector machine, decision tree and artificial neural network. Iranian Journal of Public Health. 2016; 45(9):1179-87. PMCID: PMC5149472

Shojaei A, Moradi S, Alaeddini F, Khodadoost M, Ghadirzadeh MR, Khademi A. The association between completed suicides and season of the year in an Iranian population. Iranian Journal of Public Health. 2013; 42(3):293-7. PMCID: PMC3633799

Koromilas C, Liapi C, Schulpis KH, Kalafatakis K, Zarros A, Tsakiris S. Structural and functional alterations in the hippocampus due to hypothyroidism. Metabolic Brain Disease. 2010; 25(3):339–54. doi: 10.1007/s11011-010-9208-8.

World Health Organization. Preventing suicide: A global imperative. Geneva: World Health Organization; 2014.

Bertolote JM, Fleischmann A. A global perspective in the epidemiology of suicide. Suicidologi. 2015; 7(2). doi: 10.5617/suicidologi.2330

Pritchard C, Amanullah S. An analysis of suicide and undetermined deaths in 17 predominantly Islamic countries contrasted with the UK. Psychological Medicine. 2007; 37(3):421-30. doi: 10.1017/s0033291706009159

Bauer M, Goetz T, Glenn T, Whybrow PC. The thyroid-brain interaction in thyroid disorders and mood disorders. Journal of Neuroendocrinology . 2008; 20(10):1101-14. doi: 10.1111/j.1365-2826.2008.01774.x

Eshraghi A, Arshad M, Samadanifar H, Eshraghi M, Ghafoori SMS, Rangraz Jeddy M, et al. [The relationship between thyroid function and recent history of suicide attempt in patients with major depression (Persian)]. Qom University of Medical Sciences Journal. 2016; 9(12):35-40.

Lewitzka U, Doucette S, Seemuller F, Grof P, Duffy AC. Biological indicators of suicide risk in youth with mood disorders: what do we know so far? Current Psychiatry Reports. 2012; 14(6):705-12. doi: 10.1007/s11920-012-0329-0

Bermudes RA. Psychiatric illness or thyroid disease? Don’t be misled by false lab tests. Current Psychiatry. 2002; 1(5):51-61.

Brownlie BE, Rae AM, Walshe JW, Wells JE. Psychoses associated with thyrotoxicosis - ‘thyrotoxic psychosis.’ A report of 18 cases, with statistical analysis of incidence. European Journal of Endocrinology. 2000; 142(5):438-44. doi: 10.1530/eje.0.1420438

Davis JD, Tremont G. Neuropsychiatric aspects of hypothyroidism and treatment reversibility. Minerva Endocrinologica. 2007; 32(1):49-65. PMID: 17353866

Howland RH. Thyroid dysfunction in refractory depression: implications for pathophysiology and treatment. The Journal of Clinical Psychiatry. 1993; 54(2):47-54. PMID: 8444820

Freeman ME, Kanyicska B, Lerant A, Nagy G. Prolactin: structure, function, and regulation of secretion. Physiological Reviews. 2000; 80(4):1523-631. doi: 10.1152/physrev.2000.80.4.1523

Torre DL, Falorni A. Pharmacological causes of hyperprolactinemia. Therapeutics and Clinical Risk Management . 2007; 3(5):929-51. PMID: 18473017

Rajkumar RP. Prolactin and psychopathology in schizophrenia: A literature review and reappraisal. Schizophrenia research and treatment. 2014; 2014:1–12. doi: 10.1155/2014/175360

Pompili M, Gibiino S, Innamorati M, Serafini G, Del Casale A, De Risio L, et al. Prolactin and thyroid hormone levels are associated with suicide attempts in psychiatric patients. Psychiatry Research. 2012; 200(2-3):389–94. doi: 10.1016/j.psychres.2012.05.010

Krejcie RV, Morgan DW. Determining sample size for research activities. Educational and Psychological Measurement. 1970; 30(3):607–10. doi: 10.1177/001316447003000308

Duval F, Mokrani MC, Lopera FG, Diep TS, Rabia H, Fattah S. Thyroid axis activity and suicidal behavior in depressed patients. Psychoneuroendocrinology. 2010; 35(7):1045-54. doi: 10.1016/j.psyneuen.2010.01.005

Jose J, Nandeesha H, Kattimani S, Meiyappan K, Sarkar S, Sivasankar D. Association between prolactin and thyroid hormones with severity of psychopathology and suicide risk in drug free male schizophrenia. Clinica Chimica Acta. 2015; 444:78–80. doi: 10.1016/j.cca.2015.02.003

Ozcan H, Yucel A, Atis O, Yucel N, Bilen A, Emet M, et al. Thyroxin levels associated with current suicide attempts: a case control and follow-up study. Klinik Psikofarmakoloji Bülteni-Bulletin of Clinical Psychopharmacology. 2016; 26(3):278–86. doi: 10.5455/bcp.20160217101946

Lennartsson AK, Jonsdottir IH. Prolactin in response to acute psychosocial stress in healthy men and women. Psychoneuroendocrinology. 2011; 36(10):1530–9. doi: 10.1016/j.psyneuen.2011.04.007

Bahar A, Akha O, Kashi Z, Vesgari Z. Hyperprolactinemia in association with subclinical hypothyroidism. Caspian Journal of Internal Medicine. 2011; 2(2):229-33. PMCID: PMC3766941

Raber W, Gessl A, Nowotny P, Vierhapper H. Hyperprolactinaemia in hypothyroidism: Clinical significance and impact of TSH normalization. Clinical Endocrinology. 2003; 58(2):185-91. doi: 10.1046/j.1365-2265.2003.01694.x