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Effect of Essential Oil of Rosa damascena on Human Colon Cancer Cell Line SW742

Mostafa Rezaie-Tavirani, Setareh Fayazfar, Saeid Heydari-Keshel, Mohamad Bagher Rezaee, Mona Zamanian- Azodi, Majid Rezaei-Tavirani, Reza Khodarahmi
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Abstract

Aim: In this study, the effect of the essential oil of Rosa damascena on human colon cancer cell line (SW742) and human fibroblast cells has been reported.

Background: Colon cancer is the second lethal disease after lung cancer. Owing to the existence of many side effects and problems related to common treatments such as surgery, chemotherapy and radiotherapy, better substitution is highly needed. Herbal medicine has been shown promising against different types of cancers recently; usage of their essential oils as drug contributes to a major part of traditional medicine.

Patients and Methods: The essential oil is provided by distillation method and its effects on SW742 cell line and fibroblast cells have been investigated. The cells were cultured and different volumes of essential oil were induced to the cells. After 48h incubation, cell survival was studied with MTT assay method. Using the statistical analysis, the findings were evaluated and reported.

Results: One side of the present study shows that soluble part of essential oil can possibly stimulates cell growth in high volumes and the other side outlines the growth reducing properties of the evaporation part of the essential oil.

Conclusion: Analytical data provide considerable information about pharmaceutical properties of the plant. It can be considered for discovery of drugs relating to cancer therapy and tissue engineering purposes.



DOI: https://doi.org/10.22037/ghfbb.v6i1.339