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Evaluation of GKN1 and GKN2 gene expression as a biomarker of gastric cancer

Fatemeh Dokhaee, Sogol Mazhari, Mohammad Galehdari, Ayad Bahadori Monfared, Kaveh Baghaei
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Abstract

Aim: The aim of this study was to investigate the expression of GKN1 and GKN2 genes as probable biomarkers for gastric cancer.

Background: Gastric cancer is a multifactorial process characterized by the uncontrolled growth and dissemination of abnormal cells. Survival rates of gastric cancer tend to be poor, a plausible explanation is a combination of a late-stage diagnosis and limited access to treatment. In this regard, finding relevant and measurable biomarkers is urgently needed.

Methods: 27 samples of gastric cancer tissues were enrolled into this study, according to their pathological responses. The alteration of genes expression were evaluated by Real-Time PCR technique.

Results: Our findings showed the significant reduction of Gastrokin-1 and Gastrokine-2 genes expression in the cancerous specimens in comparison with the normal tissues. (P = 0.008 and P = 0.004 respectively).

Conclusion: Our findings showed the significant reduction of Gastrokin-1 and Gastrokine-2 genes expression in the cancerous specimens in comparison with the normal tissues. (P = 0.008 and P = 0.004 respectively).

Keywords: Gastric cancer, Gastrokine-1(GKN1), Gastrokine-2 (GKN2), Real-time PCR.

(Please cite as: Dokhaee F, Mazhari S, Galehdari M, Bahadori Monfared A, Baghaei K. Evaluation of GKN1 and GKN2 gene expression as a biomarker of gastric cancer. Gastroenterol Hepatol Bed Bench 2018;11(Suppl. 1):S140-S145).


Keywords

Gastric cancer, Gastrokine-1(GKN1), Gastrokine-2 (GKN2), Real-time PCR.

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DOI: https://doi.org/10.22037/ghfbb.v0i0.1540