Celiac disease is an immune-mediated enteropathy that characteristically responds to treatment with a gluten-free diet. In most, clinical features improve with resolution of diarrhea and weight loss. Serological studies also tend to normalize. Despite this, a mucosal inflammatory process may persist, especially in the proximal small intestine. In celiac disease, resolution of histopathological changes can occur within 6 months, but often, more than a year is required, sometimes, 2 years or more. Changes are not only time-dependent, but appear to be gender-dependent with resolution more readily achieved in females compared to males, and age-dependent with more persistence of the inflammatory process in the elderly compared to younger patients. Future studies need to take into account the individual nature of the normal mucosal healing process in celiac disease treated with a gluten-free diet.
Celiac disease; Refractory and Unclassified Sprue; Gluten-sensitive Enteropathy; Endoscopic Biopsy
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