• Logo
  • SBMUJournals

Hopkins Syndrome in a 14-Year-Old Boy; a Case Report

Alireza Majidi, Sasan Saket, Zohreh Nabizadeh Gharghozar, Ehsan Akrami, Seyed Mohsen Fayyazi




Hopkins syndrome (HS) is a flaccid paralysis resembling poliomyelitis that has been seen in some children who are recovering from an acute episode of asthma. This syndrome should be suspected based on clinical findings even before the occurrence of characteristic breathing patterns and epilepsy. We report a 14-year-old boy who had experienced an episode of HS.


Pitt-Hopkins syndrome; nervous system diseases; rare diseases; asthma



Yeung SC, Antonio G, Ip KS. Flaccid paralysis of the limbs after an asthmatic attack. Pediatric neurology. 2010;42(2):133-6.

Leonardi M, Sartorius N, Hull HF, Ward NA, Organization WH. Acute onset flaccid paralysis. 1993.

Horiuchi I, Yamasaki K, Osoegawa M, Ohyagi Y, Okayama A, Kurokawa T, et al. Acute myelitis after asthma attacks with onset after puberty. Journal of Neurology, Neurosurgery & Psychiatry. 2000;68(5):665-8.

Fine PE, Carneiro IA. Transmissibility and persistence of oral polio vaccine viruses: implications for the global poliomyelitis eradication initiative. American journal of epidemiology. 1999;150(10):1001-21.

Tyler KL. Acute viral myelitis. Infections of the central nervous system. 2004:310-1.

Sejvar JJ, Leis AA, Stokic DS, Van Gerpen JA, Marfin AA, Webb R, et al. Acute flaccid paralysis and West Nile virus infection. Emerging infectious diseases. 2003;9(7):788.

Marx A, Glass JD, Sutter RW. Differential diagnosis of acute flaccid paralysis and its role in poliomyelitis surveillance. Epidemiologic reviews. 2000;22(2):298-316.

Chen C-Y, Chang Y-C, Huang C-C, Lui C-C, Lee K-W, Huang S-C. Acute flaccid paralysis in infants and young children with enterovirus 71 infection: MR imaging findings and clinical correlates. American journal of neuroradiology. 2001;22(1):200-5.

Shahmahmoodi S, Mamishi S, Aghamohammadi A, Aghazadeh N, Tabatabaie H, Gooya MM, et al. Vaccine-associated paralytic poliomyelitis in immunodeficient children, Iran, 1995–2008. Emerging infectious diseases. 2010;16(7):1133.

Piero P, Longo MR, Scalia F, Polosa R, Kira J-i, Falsaperla R. Recurrent Hopkin's syndrome: A case report and review of the literature. Journal of the neurological sciences. 2010;297(1):89-91.

Shapiro GG, Chapman JT, Pierson WE, Bierman CW. Poliomyelitis-like illness after acute asthma. The Journal of pediatrics. 1979;94(5):767-8.

Shahar EM, Hwang PA, Niesen CE, Murphy EG. Poliomyelitis-like paralysis during recovery from acute bronchial asthma: possible etiology and risk factors. Pediatrics. 1991;88(2):276-9.

Danta G. Electrophysiological study of amyotrophy associated with acute asthma (asthmatic amyotrophy). Journal of Neurology, Neurosurgery & Psychiatry. 1975;38(10):1016-21.

Liedholm LJA, Eeg‐Olofsson O, Ekenberg BEK, Nicolaysen RB, Torbergsen T. Acute postasthmatic amyotrophy (Hopkins' syndrome). Muscle & nerve. 1994;17(7):769-72.

Kira J-i, Isobe N, Kawano Y, Osoegawa M, Ohyagi Y, Mihara F, et al. Atopic myelitis with focal amyotrophy: a possible link to Hopkins syndrome. Journal of the neurological sciences. 2008;269(1):143-51.

Kimura M, Tsuruta S, Yoshida T. Differences in cytokine production by peripheral blood mononuclear cells (PBMC) between patients with atopic dermatitis and bronchial asthma. Clinical and experimental immunology. 1999;118(2):192.

Osoegawa M, Ochi H, Yamada T, Horiuchi I, Murai H, Furuya H, et al. High Incidence of Subclinical Peripheral Neuropathy in Myelitis with HyperlgEaemia and Mite Antigen-specific IgE (Atopic Myelitis): an Electrophysiological Study. Internal medicine. 2002;41(9):684-91.

Kira J-i, Kawano Y, Yamasaki K, Tobimatsu S. Acute myelitis with hyperIgEaemia and mite antigen specific IgE: atopic myelitis. Journal of Neurology, Neurosurgery & Psychiatry. 1998;64(5):676-9.

Kira J-i, Kawano Y, Horiuchi I, Yamada T, Imayama S, Furue M, et al. Clinical, immunological and MRI features of myelitis with atopic dermatitis (atopic myelitis). Journal of the neurological sciences. 1999;162(1):56-61.

Taddeucci G, Bonuccelli A, Mantellassi I, Orsini A, Tarantino E. Pitt-Hopkins syndrome: report of a case with a TCF4 gene mutation. Italian journal of pediatrics. 2010;36(1):12.

DOI: https://doi.org/10.22037/emergency.v6i1.18287


  • There are currently no refbacks.