Evaluation of allergy and eosinophilia level in peripheral blood of patients with cardiovascular diseases
Archives of Medical Laboratory Sciences,
Vol. 1 No. 1 (2015),
21 Ordibehesht 2015
https://doi.org/10.22037/amls.v1i1.8962
Abstract
Background: Cardiovascular diseases are the most common cause of deaths in Iran and other developing countries. The risk factors for cardiovascular diseases are divided into two categories; the variable risk factors and the non-variable risk factors. Many recent studies evaluated the relationship between higher eosinophilia and allergy levels with the incidence, progress and severity of cardiovascular diseases, but the exact correlation between these two still remains unknown. The current study was designed to assess the relationship between allergic responses and eosinophilia amongst patients with cardiovascular diseases in Ilam province, in comparison with healthy individuals.
Materials and Methods: In this case-control study, we enrolled 59 cardiovascular patients and 55 healthy individuals without any history of allergy and parasitic infections. A questionnaire including questions about demographic data, family history of heart disease, history of diabetes, hyperlipidemia, physical activity, smoking, stress, dietary fat consumption, salt intake, allergies to certain substances, history of parasitic disease and history of hypertension was completed. The blood was taken from each participant and CBC and IgE titer were measured.
Results: There was a significant relationship for the variables such as the family history of cardiovascular disease (P<0.001), diabetes (P<0.003), hyperlipidemia (P<0.0001), high blood pressure (P<0.0001) and physical activity (P<0.0001) between the case and the control groups. The mean IgE titer in case group was 95.3±71 and 62.44±49 in control group. The mean eosinophilia level in peripheral blood was 3.95±1.057 in case and 1.53±0.57 in control group. The difference between the IgE and eosinophilia levels in the case and the control groups was statistically significant (P<0.0001).
Conclusion: Based on our results, it can be concluded the increase in levels of IgE and eosinophilia can be considered by cardiologists as a reliable diagnostic tool for predicting cardiovascular diseases.
- Cardiovascular
- Eosinophil
- IgE
How to Cite
References
Thomas A, Gaziano S. Cardiovascular disease in the developing world and its cost-effective management. Circulation. 2005;112(23):3547-53.
Wang Z, Klipfell E, Brian J, Koeth R, Bruce S, Levison A, et al. Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease. Nature. 2011;472(7341):57-63.
Khor GL. Cardiovascular epidemiology in the Asia–Pacific region. Asia Pacific journal of clinical nutrition. 2001;10(2):76-80.
Anand K, Parekh MD, James M, Galloway MD, Hong Y, Janet S, et al. Aspirin in the secondary prevention of cardiovascular disease. N Engl J Med. 2013;368(3):204-5.
Brugts JJ, Yetgin T, Hoeks SE, Gotto AM, Shepherd J, Westendorp RG, et al. The benefits of statins in people without established cardiovascular disease but with cardiovascular risk factors: meta-analysis of randomised controlled trials. BMJ: British Medical Journal. 2009;338.
Jarett D, Alan-Dyer B, Cai X, Garside D, Ning H, Thomas A, et al. Lifetime Risks of Cardiovascular Disease. N Engl J Med. 2012;366(4):321-9.
Dodu SR. Emergence of cardiovascular diseases in developing countries. Cardiology. 2008;75(1):56-64.
Joffres MR, Hamet P, MacLean DR, L'italien GJ, Fodor Gl. Distribution of blood pressure and hypertension in Canada and the United States*. American Journal of Hypertension. 2001;14(11):1099-105.
Sarraf-Zadegan N, Boshtam M, Malekafzali H, Bashardoost N, Sayed-Tabatabaei FA, Rafiei M, et al. Secular trends in cardiovascular mortality in Iran, with special reference to Isfahan. Acta cardiologica. 1999;54(6):327-33.
Dahlöf B. Cardiovascular disease risk factors: epidemiology and risk assessment. The American journal of cardiology. 2010;105(1):3-9.
Ueshima H, Sekikawa A, Miura K, Chowdhury-Turin T, Takashima N, Kita Y, et al. Cardiovascular Disease and Risk Factors in Asia A Selected Review. Circulation. 2008;118(25):2702-9.
Azizi F, Rahmani M, Emami H, Mirmiran P, Hajipour R, Madjid M, et al. Cardiovascular risk factors in an Iranian urban population: Tehran lipid and glucose study (phase 1). Sozial-und präventivmedizin. 2002;47(6):408-26.
Gersh BJ, Sliwa K, Mayosi BM, Yusuf S. Novel therapeutic conceptsThe epidemic of cardiovascular disease in the developing world: global implications.European heart journal. 2010;31(6):642-8.
Chou HC, Chang JR. Extracting drug utilization knowledge using self-organizing map and rough set theory. Expert systems with Applications. 2007;33(2):499-508.
Manolio TA, Burke GL, Psaty BM, Newman AB, Haan M, Powe N, et al. Black-white differences in subclinical cardiovascular disease among older adults: the Cardiovascular Health Study. Journal of clinical epidemiology. 1995;48(9):1141-52.
Yusuf S, Hawken S, Ounpuu S, Dans T, Avezum A, Lanas F, et al. Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study. The Lancet. 2004;364(9438):937-52.
Kounis NG, Giannopoulos S, Tsigkas GG, Goudevenos J. Eosinophilic responses to stent implantation and the risk of Kounis hypersensitivity associated coronary syndrome. International journal of cardiology. 2012;156(2):125-32.
Kounis NG, Kounis GN, Kouni SN, Soufras GD, Niarchos C, Mazarakis A. Allergic reactions following implantation of drug-eluting stents: a manifestation of Kounis syndrome? Journal of the American College of Cardiology. 2006;48(3):592-3.
Triggiani M, Patella V, Staiano RI, Granata F, Marone G. Allergy and the cardiovascular system. Clinical & Experimental Immunology. 2008;153(s1):7-11.
Kounis NG, Kouni SN, Almpanis G, Mazarakis A, Soufras GD. Eosinophilic coronary arteritis, hypersensitivity myocarditis and the Kounis hypersensitivity associated acute coronary syndrome. Journal of forensic nursing. 2012;8(4):195-6.
Kounis, N, Zavras G. Histamine-induced coronary artery spasm: the concept of allergic angina. The British journal of clinical practice. 1991;45(2):121-8.
Kounis NG. Kounis syndrome (allergic angina and allergic myocardial infarction): a natural paradigm? International journal of cardiology. 2006;110(1):7-14.
Sinkiewicz W, Sobanski P, Bartuzi Z. Allergic myocardial infarction. Cardiology Journal. 2008;15(3):220.
Kounis NG. Eosinophils and Kounis hypersensitivity associated syndrome as contributors to very late coronary stent thrombosis. International Journal of Cardiology.
Biteker M. Current understanding of Kounis syndrome. Expert review of clinical immunology. 2010;6(5):777-88.
Ozben B, Erdogan O. The role of inflammation and allergy in acute coronary syndromes. Inflammation & Allergy-Drug Targets. 2008;7(3):136-44.
Gollapudi RR, Teirstein PS, Stevenson DD, Simon RA. Aspirin sensitivity: Implications for patients with coronary artery disease. JAMA. 2004;292(24):3017-23.
López-Abad R, Rodríguez F, García-Abujeta JL, Martín-Gil D, Jerez J. Myocardial ischemia due to severe amoxicillin allergy. J Investig Allergol Clin Immunol. 2004;14(2):162-4.
Viana-Tejedor A, Espinosa MÁ, Cuesta J, Núñez A, Bueno H, Fernández-Avilés F. Kounis syndrome secondary to amoxicillin use in an asthmatic patient. International Journal of Cardiology. 2011;150(3):113-5.
Biteker M, Duran NE, Biteker FS, Ertürk E, Aykan AC, Civan HA, et al. Kounis Syndrome secondary to amoxicillin/clavulanic acid use in a child. International journal of cardiology. 2009;136(1):3-5.
Sinkiewicz W, Błazejewski J, Bujak R, Kubica J, Dudziak J. Immunoglobulin E in patients with ischemic heart disease. Cardiology Journal. 2008;15(2):122-8.
Criqui MH, Lee ER, Hamburger RN, Klauber MR, Coughlin SS. IgE and cardiovascular disease: results from a population-based study. The American journal of medicine. 1987;82(5):964-8.
Ogbogu PU, Rosing DR, Horne III. Cardiovascular manifestations of hypereosinophilic syndromes. Immunology and allergy clinics of North America. 2007;27(3):457-75.
Parrillo JE, Borer JS, Henry WL, Wolff SM, Fauci AS. The cardiovascular manifestations of the hypereosinophilic syndrome: prospective study of 26 patients, with review of the literature. The American journal of medicine. 1979;67(4):572-82.
Kleinfeldt T, Nienaber CA, Kische S, Akin I, Turan RG, Körber T, et al. Cardiac manifestation of the hypereosinophilic syndrome: new insights. Clinical research in cardiology. 2010;99(7):419-27.
Gleich GJ, Leiferman KM. The hypereosinophilic syndromes: current concepts and treatments. British journal of haematology. 2009;145(3):271-85.
Bernabe-Ortiz A, Benziger CP, Gilman RH, Smeeth L, Miranda JJ. Sex differences in risk factors for cardiovascular disease: The PERU MIGRANT study. PloS one. 2012;7(4):35127.
Barrett KM, Brott TG, Brown J, Frankel MR, Worrall BB, Silliman SL, et al. Sex differences in stroke severity, symptoms, and deficits after first-ever ischemic stroke. Journal of Stroke and Cerebrovascular Diseases. 2007;16(1):34-9.
Bazzano LA, Gu D, Whelton MR, Wu X, Chen CS, Duan X, et al. Body mass index and risk of stroke among Chinese men and women. Annals of neurology. 2010;67(1):11-20.
Pasquarella A, Buonomo E, Carbini R, Palombi L. Family history of cardiovascular diseases and risk factors in children. Journal of human hypertension. 1996;10:107-9.
Hewitt S, Graff-Iversen S. Risk factors for cardiovascular diseases and diabetes in disability pensioners aged 40-42 years: a cross-sectional study in Norway. Scand J Public Health. 2009;37(3):280-6.
Perez-Gomez G, Huffman FG. Risk Factors for Type 2 Diabetes and Cardiovascular Diseases in Hispanic Adolescents. The Journal of adolescent health: official publication of the Society for Adolescent Medicine. 2008;43(5):444-50.
Makedou A, Kourti M, Makedou K, Lazaridou S, Varlamis G. Lipid profile of children with a family history of coronary heart disease or hyperlipidemia: 9-year experience of an outpatient clinic for the prevention of cardiovascular diseases. Angiology. 2005;56(4):391-5.
Wang Y. The Impact of Blood Pressure on the Risk for Cardiovascular Diseases: What Should Be Done Now? American Journal of Hypertension. 2008;21(3):247.
He FJ, MacGregor GA. Salt, blood pressure and cardiovascular disease . curr opin cardiol. 2007;22(4):298-305.
Haennel RG, Lemire F. Physical activity to prevent cardiovascular disease. How much is enough? Canadian Family Physician. 2002;48(1):65-71.
Bairey-Merz CN, Dwyer J, Nordstrom CK, Walton KG, Salerno JW, Schneider RH.. Psychosocial stress and cardiovascular disease: pathophysiological links. Behavioral Medicine. 2002;27(4):141-7.
Vale S. Psychosocial stress and cardiovascular diseases. Postgraduate medical journal. 2005;81(957):429-35.
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