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The association between intracellular electrolytes and obesity indices

Reyhane Ebrahimi, Naghmeh Jannat Alipour, Solaleh Emamgholipour
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Abstract

Background: Obesity with a rapid grow in developed and developing countries has a close association with higher disposition to related diseases such as hypertension. Intracellular functions of sodium, potassium, calcium, phosphate, and iron have been an interested subject in obese patients since their dysregulations are linked to a higher risk of hypertension and other metabolic disorders.

Materials and Methods: In this study, the circulating levels of sodium, potassium, calcium, phosphate, and iron were determined in the serum of obese patients compared to normal-weight people. Moreover, we examined the correlation of such electrolytes with the well-known indices of obesity such as body mass index (BMI), waist circumference (WC), hip, triglycerides (TG), cholesterol and other characterizations.

Results: The mean levels of sodium, potassium, calcium, phosphate, and iron were significantly different (p < 0.05) in obese patients compared to normal-weight subjects. We observed a positive partial correlation between the levels of these electrolytes and obesity indices such as BMI, WC, hip, and cholesterol.

Conclusion: Collectively, the present study suggests the positive correlation between obesity and the indices of metabolic disorders such as hypertension and renal failure according to the observed imbalances in the concentration of electrolytes. Moreover, efforts for diet modification may be helpful in the programs aimed at decreasing the burden of obesity and related disorders.


Keywords

Obesity, electrolytes, body mass index, waist circumference.

References

Friedman JM. Obesity in the new millennium. Nature. 2000;404(6778):632-4.

Wei S, Du M, Jiang Z, Hausman GJ, Zhang L, Dodson MV. Long noncoding RNAs in regulating adipogenesis: new RNAs shed lights on obesity. Cellular and molecular life sciences : CMLS. 2016;73(10):2079-87.

Fitzgerald S, Kirby A, Murphy A, Geaney F. Obesity, diet quality and absenteeism in a working population. Public health nutrition. 2016;19(18):3287-95.

Cai X, Li X, Fan W, Yu W, Wang S, Li Z, et al. Potassium and Obesity/Metabolic Syndrome: A Systematic Review and Meta-Analysis of the Epidemiological Evidence. Nutrients. 2016;8(4):183.

Elfassy T, Mossavar-Rahmani Y, Van Horn L, Gellman M, Sotres-Alvarez D, Schneiderman N, et al. Associations of Sodium and Potassium with Obesity Measures Among Diverse US Hispanic/Latino Adults: Results from the Hispanic Community Health Study/Study of Latinos. Obesity (Silver Spring, Md). 2018;26(2):442-50.

Reisin E. Sodium and obesity in the pathogenesis of hypertension. Am J Hypertens. 1990;3(2):164-7.

Ndanuko RN, Tapsell LC, Charlton KE, Neale EP, O'Donnell KM, Batterham MJ. Relationship between sodium and potassium intake and blood pressure in a sample of overweight adults. Nutrition (Burbank, Los Angeles County, Calif). 2017;33:285-90.

Santhanam P, Shapiro JI, Khitan Z. Association between dietary potassium, body mass index, and proteinuria in normotensive and hypertensive individuals: Results from the Modification of Diet in Renal Disease study baseline data. Journal of clinical hypertension (Greenwich, Conn). 2017;19(5):558-9.

Ellison RC, Sosenko JM, Harper GP, Gibbons L, Pratter FE, Miettinen OS. Obesity, sodium intake, and blood pressure in adolescents. Hypertension. 1980;2(4 Pt 2):78-82.

Hulthen L, Aurell M, Klingberg S, Hallenberg E, Lorentzon M, Ohlsson C. Salt intake in young Swedish men. Public health nutrition. 2010;13(5):601-5.

Jain N, Minhajuddin AT, Neeland IJ, Elsayed EF, Vega GL, Hedayati SS. Association of urinary sodium-to-potassium ratio with obesity in a multiethnic cohort. The American journal of clinical nutrition. 2014;99(5):992-8.

Larsen SC, Angquist L, Sorensen TI, Heitmann BL. 24h urinary sodium excretion and subsequent change in weight, waist circumference and body composition. PLoS One. 2013;8(7):e69689.

Libuda L, Kersting M, Alexy U. Consumption of dietary salt measured by urinary sodium excretion and its association with body weight status in healthy children and adolescents. Public health nutrition. 2012;15(3):433-41.

Räisänen JP, Silaste M-L, Kesäniemi YA, Ukkola O. Increased daily sodium intake is an independent dietary indicator of the metabolic syndrome in middle-aged subjects. Annals of Medicine. 2012;44(6):627-34.

Song HJ, Cho YG, Lee HJ. Dietary sodium intake and prevalence of overweight in adults. Metabolism. 2013;62(5):703-8.

Yi SS, Kansagra SM. Associations of sodium intake with obesity, body mass index, waist circumference, and weight. American journal of preventive medicine. 2014;46(6):e53-5.

Yoon YS, Oh SW. Sodium density and obesity; the Korea National Health and Nutrition Examination Survey 2007-2010. Eur J Clin Nutr. 2013;67(2):141-6.

Loftfield E, Yi S, Immerwahr S, Eisenhower D. Construct Validity of a Single-Item, Self-Rated Question of Diet Quality. Journal of Nutrition Education and Behavior. 2015;47(2):181-7.

Cai X, Li X, Fan W, Yu W, Wang S, Li Z, et al. Potassium and Obesity/Metabolic Syndrome: A Systematic Review and Meta-Analysis of the Epidemiological Evidence. Nutrients. 2016;8(4):183.

Zafari AM, Davidoff MN, Austin H, Valppu L, Cotsonis G, Lassegue B, et al. The A640G and C242T p22(phox) polymorphisms in patients with coronary artery disease. Antioxidants & redox signaling. 2002;4(4):675-80.

Cai X, Li X, Fan W, Yu W, Wang S, Li Z, et al. Potassium and Obesity/Metabolic Syndrome: A Systematic Review and Meta-Analysis of the Epidemiological Evidence. Nutrients. 2016;8(4):183.

Elfassy T, Mossavar-Rahmani Y, Van Horn L, Gellman M, Sotres-Alvarez D, Schneiderman N, et al. Associations of Sodium and Potassium with Obesity Measures Among Diverse US Hispanic/Latino Adults: Results from the Hispanic Community Health Study/Study of Latinos. Obesity (Silver Spring, Md). 2018;26(2):442-50.

Rafie N, Mohammadifard N, Khosravi A, Feizi A, Safavi SM. Relationship of sodium intake with obesity among Iranian children and adolescents. ARYA Atheroscler. 2017;13:1-6.

Bahadoran Z, Mirmiran P, Golzarand M, Hosseini-Esfahani F, Azizi F. Fast food consumption in Iranian adults; dietary intake and cardiovascular risk factors: Tehran Lipid and Glucose Study. Archives of Iranian medicine. 2012;15(6):346-51.

Hulthen L, Aurell M, Klingberg S, Hallenberg E, Lorentzon M, Ohlsson C. Salt intake in young Swedish men. Public health nutrition. 2010;13(5):601-5.

Larsen SC, Ängquist L, Sørensen TI, Heitmann BL. 24h urinary sodium excretion and subsequent change in weight, waist circumference and body composition. PLoS One. 2013;8(7):e69689.

Libuda L, Kersting M, Alexy U. Consumption of dietary salt measured by urinary sodium excretion and its association with body weight status in healthy children and adolescents. Public health nutrition. 2012;15(3):433-41.

Song HJ, Cho YG, Lee HJ. Dietary sodium intake and prevalence of overweight in adults. Metabolism. 2013;62(5):703-8.

Zhu H, Pollock NK, Kotak I, Gutin B, Wang X, Bhagatwala J, et al. Dietary sodium, adiposity, and inflammation in healthy adolescents. Pediatrics. 2014;133(3):e635-42.

Yi SS, Firestone MJ, Beasley JM. Independent associations of sodium intake with measures of body size and predictive body fatness. Obesity (Silver Spring, Md). 2015;23:20-3.

Cogswell ME, Mugavero K, Bowman BA, Frieden TR. Dietary Sodium and Cardiovascular Disease Risk--Measurement Matters. The New England journal of medicine. 2016;375(6):580-6.

Räisänen JP, Silaste M-L, Kesäniemi YA, Ukkola O. Increased daily sodium intake is an independent dietary indicator of the metabolic syndrome in middle-aged subjects. Annals of Medicine. 2012;44(6):627-34.

Yoon YS, Oh SW. Sodium density and obesity; the Korea National Health and Nutrition Examination Survey 2007-2010. Eur J Clin Nutr. 2013;67(2):141-6.

Hulthen L, Aurell M, Klingberg S, Hallenberg E, Lorentzon M, Ohlsson C. Salt intake in young Swedish men. Public health nutrition. 2010;13(5):601-5.

Yi SS, Firestone MJ, Beasley JM. Independent associations of sodium intake with measures of body size and predictive body fatness. Obesity (Silver Spring, Md). 2015;23:20-3.

Hoffmann IS, Cubeddu LX. Salt and the metabolic syndrome. Nutrition, metabolism, and cardiovascular diseases : NMCD. 2009;19(2):123-8.

Ma Y, He FJ, MacGregor GA. High salt intake: independent risk factor for obesity? Hypertension. 2015;66(4):843-9.

Zhu H, Pollock NK, Kotak I, Gutin B, Wang X, Bhagatwala J, et al. Dietary sodium, adiposity, and inflammation in healthy adolescents. Pediatrics. 2014;133(3):e635-42.

Fonseca-Alaniz MH, Brito LC, Borges-Silva CN, Takada J, Andreotti S, Lima FB. High dietary sodium intake increases white adipose tissue mass and plasma leptin in rats. Obesity (Silver Spring, Md). 2007;15(9):2200-8.

Grimes CA, Riddell LJ, Campbell KJ, He FJ, Nowson CA. 24-h urinary sodium excretion is associated with obesity in a cross-sectional sample of Australian schoolchildren. The British journal of nutrition. 2016;115(6):1071-9.

Libuda L, Kersting M, Alexy U. Consumption of dietary salt measured by urinary sodium excretion and its association with body weight status in healthy children and adolescents. Public health nutrition. 2012;15(3):433-41.

Elfassy T, Mossavar-Rahmani Y, Van Horn L, Gellman M, Sotres-Alvarez D, Schneiderman N, et al. Associations of Sodium and Potassium with Obesity Measures Among Diverse US Hispanic/Latino Adults: Results from the Hispanic Community Health Study/Study of Latinos. Obesity (Silver Spring, Md). 2018;26(2):442-50.

Woodruff SJ, Fryer K, Campbell T, Cole M. Associations among blood pressure, salt consumption and body weight status of students from south-western Ontario. Public health nutrition. 2014;17(5):1114-9.

Beydoun, M.A., et al., Ethnic differences in dairy and related nutrient consumption among US adults and their association with obesity, central obesity, and the metabolic syndrome. Am J Clin Nutr, 2008. 87(6): p. 1914-25.

Dhingra, R., et al., Relations of serum phosphorus and calcium levels to the incidence of cardiovascular disease in the community. Arch Intern Med, 2007. 167(9): p. 879-85.

Kestenbaum, B., et al., Serum phosphate levels and mortality risk among people with chronic kidney disease. J Am Soc Nephrol, 2005. 16(2): p. 520-8.

Tonelli, M., et al., Relation between serum phosphate level and cardiovascular event rate in people with coronary disease. Circulation, 2005. 112(17): p. 2627-33.

Kalaitzidis, R., et al., Disturbances of phosphate metabolism: another feature of metabolic syndrome. Am J Kidney Dis, 2005. 45(5): p. 851-8.

Beydoun, M.A., et al., Ethnic differences in dairy and related nutrient consumption among US adults and their association with obesity, central obesity, and the metabolic syndrome. Am J Clin Nutr, 2008. 87(6): p. 1914-25.

Oyadomari, S. and M. Mori, Roles of CHOP/GADD153 in endoplasmic reticulum stress. Cell death and differentiation, 2004. 11(4): p. 381.

Aderibigbe, O.R., et al., The relationship between indices of iron status and selected anthropometric cardiovascular disease risk markers in an African population: the THUSA study. Cardiovasc J Afr, 2011. 22(5): p. 249-56.




DOI: https://doi.org/10.22037/amls.v4i2.26275

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