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  3. Vol. 23 No. 00 (2026): Instant 2026
  4. CASE REPORT

Vol. 23 No. 00 (2026)

January 2026

Renal Pelvis Epidermoid Cyst Mimicking Staghorn Calculus: Successful Treatment with Percutaneous Approach (PCN)

  • Hamid Pakmanesh
  • Reza Malekpour Afshar
  • Mohammad Mehdi Moeini-aghtaei

Urology Journal, Vol. 23 No. 00 (2026), 24 January 2026 , Page 8845
https://doi.org/10.22037/uj.v23i00.8845 Published: 2026-08-02

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Abstract

Background: Renal pelvis epidermoid cysts are extremely rare and often misdiagnosed as stones or tumors. Only one previous case has been treated via the percutaneous approach (PCN).

Case Presentation: A 67-year-old diabetic female on Empagliflozin presented with imaging suggestive of a staghorn calculus. During Percutaneous Nephrolithotomy (PCNL), whitish keratinous material was found in the renal pelvis along with a small obstructing stone. All material was evacuated through the Amplatz sheath. Urine culture was negative. Histopathology confirmed an epidermoid cyst. Postoperative CT scan at one month showed complete resolution.

Discussion: Epidermoid cysts can mimic staghorn calculi radiologically. A Fungal ball was initially suspected due to diabetes and SGLT2 inhibitor therapy, but radiopacity, negative culture, and histology ruled this out. PCNL served as both a diagnostic and therapeutic procedure, preserving renal function.

Conclusion: Renal pelvis epidermoid cysts should be considered in the differential diagnosis of opaque pelvic lesions. PCNL is a minimally invasive, kidney-preserving treatment that can be performed as a renal-sparing procedure.

Keywords:
  • epidermal cyst
  • renal pelvis
  • staghorn calculi
  • Empagliflozin
  • Percutaneous
  • Just Accepted/8845

How to Cite

Pakmanesh, H., Malekpour Afshar, R., & Moeini-aghtaei, M. M. (2026). Renal Pelvis Epidermoid Cyst Mimicking Staghorn Calculus: Successful Treatment with Percutaneous Approach (PCN). Urology Journal, 23(00), 8845. https://doi.org/10.22037/uj.v23i00.8845
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References

(1) D, P., S, S., S, S., al., e.: Epidermoid Cyst of the Renal Pelvis Masquerading as Malignancy. Indian J Pathol Microbiol, 60: 571, 2017

(2) J, G., Y, L., J, Z., al., e.: Renal Epidermoid Cyst Mimicking Renal Tuberculous Abscess: A Case Report. Front Med, 12: 1632764, 2025

(3) KI, A.-O., al., e.: Epidermoid cyst of the kidney: case report and literature review. Urol Ann, 6: 245, 2014

(4) SZ, K., TI, P., SH, L., JS, K.: Epidermoid Cyst in the Renal Pelvis: A Case Report. Korean J Pathol, 38: 270, 2004

(5) JF, L., al., e.: SGLT2 inhibition and risk of genital and urinary tract infections. Diabetes Care, 32: 2013, 2009

(6) Karlin, G., Rich, M., Lee, W. O. N., Smith, A. D.: Endourological Management of Upper-Tract Fungal Infection. Journal of Endourology, 1: 49, 1987

(7) PB, P., al., e.: Renal tuberculosis: a review of radiological features and management. Indian J Urol, 32: 50, 2016

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