Prognostic Significance of the Controlling Nutritional Status (CONUT) Score in Patients with Muscle-Invasive Bladder Cancer after Radical Cystectomy
Urology Journal,
Vol. 21 No. 06 (2024),
27 November 2024
,
Page 390-396
https://doi.org/10.22037/uj.v21i.8266
Abstract
Purpose: To assess the impact of the The Controlling Nutritional Status (CONUT) score, an indicator of nutritional
status, on the survival and prognosis after radical cystectomy.
Materials and Methods: The medical records of patients who underwent consecutive radical cystectomy operations with the diagnosis of muscle-invasive bladder cancer at our clinic were retrospectively examined. The
patients were separated into two groups based on the cut-off CONUT score which was derived using the receiver
operating characteristic (ROC) curve. The group with a CONUT score ≥ 3 was categorized as high CONUT,
whereas the group with a CONUT score < 3 was categorized as low CONUT. The groups were compaired according
to oncological outcomes and survival risk factors.
Results: Cancer-specific survival (CSS) and overall survival (OS) were statistically significantly lower in the High
CONUT group compared to the Low CONUT group (p < 0.001, p = 0.024, respectively). Age (HR: 1.02, 95% CI:
1.006-1.04, p = 0.011) and CONUT score (HR: 3.92, 95% CI: 2.66-5.77, p < 0.001) were revealed to be independent
prognostic variables in the multivariate analysis for OS.
Conclusion: The CONUT score was found to be an independent predictor of survival in patients with muscle-invasive bladder cancer in this study.
- Bladder cancer
- overall survival
- The Controlling Nutritional Status
How to Cite
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