Survival Differences in High-Risk Prostate Cancer By Age
Vol. 20 (2023),
Purpose : Age is an established determining factor in survival in low-risk prostate cancer (PC), being this evidence weaker in high-risk tumors.
Our aim is to evaluate the survival of patients with high-risk PC treated with curative intent and to identify differences across age at diagnosis.
Methods: We did a retrospective analysis of patients with high-risk PC treated with surgery (RP) or radiotherapy (RDT) excluding N+ patients. We divided patients by age groups: <60, 60-70 and >70 years.
We performed a comparative survival analysis.A multivariate analysis adjusted for clinically relevant variables and initial treatment received was performed.
Results: Of a total of 2383 patients, 378 met the selection criteria with a median follow-up of 8.9 years: 38 (10.1%) <60 years, 175 (46.3%) between 60-70 years, and 165 (43.6%) >70 years.
Initial treatment with surgery was predominant in the younger group (RP:63.2%, RDT:36.8%), and with radiotherapy in the older group (RP:17%, RDT:83%) (p=0.001).
In the survival analysis, significant differences were observed in overall survival, with better results for the younger group. However, these results were reversed in biochemical recurrence-free survival, with patients <60 years presenting a higher rate of biochemical recurrence at 10 years.
In the multivariate analysis, age behaved as an independent risk variable only for overall survival, with a HR of 2.8 in the group >70 years (95%CI: 1.22-6.5; p=0.015).
Conclusion: In our series, age appeared to be an independent prognostic factor for overall survival, with no differences in the rest of the survival rates.
- high-risk prostate cancer, age groups, survival differences.
How to Cite
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