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  3. Vol. 20 (2023): Instant 2023
  4. ORIGINAL PAPER(UROLOGICAL ONCOLOGY)

ISSN: 1735-1308

Instant 2023
Vol. 20 (2023)

Survival Differences in High-Risk Prostate Cancer By Age

  • Clara García Fuentes
  • Ana Guijarro
  • Virginia Hernández
  • Álvaro Gonzalo
  • Estíbaliz Jiménez
  • Enrique de la Peña
  • Elia Pérez
  • Elia Pérez
  • Carlos Llorente

Urology Journal, Vol. 20 (2023), , Page 7393
https://doi.org/10.22037/uj.v20i.7393 Published 18 March 2023

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Abstract

Purpose : Age is an established determining factor in survival in low-risk prostate cancer (PC), being this evidence weaker in high-risk tumors.


Our aim is to evaluate the survival of patients with high-risk PC treated with curative intent and to identify differences across age at diagnosis.


Methods: We did a retrospective analysis of patients with high-risk PC treated with surgery (RP) or radiotherapy (RDT) excluding N+ patients. We divided patients by age groups: <60, 60-70 and >70 years.


We performed a comparative survival analysis.A multivariate analysis adjusted for clinically relevant variables and initial treatment received was performed.


Results: Of a total of 2383 patients, 378 met the selection criteria with a median follow-up of 8.9 years: 38 (10.1%) <60 years, 175 (46.3%) between 60-70 years, and 165 (43.6%) >70 years.


Initial treatment with surgery was predominant in the younger group (RP:63.2%, RDT:36.8%), and with radiotherapy in the older group (RP:17%, RDT:83%) (p=0.001).


In the survival analysis, significant differences were observed in overall survival, with better results for the younger group. However, these results were reversed in biochemical recurrence-free survival, with patients <60 years presenting a higher rate of biochemical recurrence at 10 years.


In the multivariate analysis, age behaved as an independent risk variable only for overall survival, with a HR of 2.8 in the group >70 years (95%CI: 1.22-6.5; p=0.015).


Conclusion: In our series, age appeared to be an independent prognostic factor for overall survival, with no differences in the rest of the survival rates.

Keywords:
  • high-risk prostate cancer, age groups, survival differences.
  • Just Accepted-7393

How to Cite

García Fuentes, C., Guijarro, A., Hernández, V., Gonzalo , Álvaro, Jiménez, E., de la Peña, E., Pérez, E., Pérez, E., & Llorente, C. (2023). Survival Differences in High-Risk Prostate Cancer By Age. Urology Journal, 20, 7393. https://doi.org/10.22037/uj.v20i.7393
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