Comparison of the Effectiveness of Pre-urodynamic Single-dose Levofloxacin with Post-urodynamic Levofloxacin for Three Days Related to the Incidence of Urinary Tract Infection: A Randomized Control Trial
Purpose: The current study aims to compare the effectiveness of pre-urodynamic single-dose levofloxacin and post-urodynamic levofloxacin for three days related to the incidence of urinary tract infections post-urodynamic examination.
Materials and Methods: This is a single-blind randomized clinical trial conducted in three outpatient urology centers in Jakarta: Cipto Mangunkusumo General Hospital, Siloam Asri Hospital, and Persahabatan General Hospital using a consecutive sampling method between July 2019 - February 2022. The outcome of the study is the incidence of urinary tract infections in both treatment groups. Urinary tract infection was defined as a patient with one or more clinical symptoms of lower urinary tract infection and one or more urinalysis parameters positive for urinary tract infections. Chi-square was used to evaluate the association where p < 0.05 was used to determine statistical significance.
Results: A total of 126 patients (63 patients in each arm) were included in the evaluation and analysis. Overall, urinary tract infections were detected in 25 cases (19.8%), 12 patients from the pre-urodynamic antibiotic group (9.5%) and 13 patients from the post-urodynamic antibiotic group (10.3%) (P = .823). E.coli was the most common bacteria found in the urine culture.
Conclusion:There is no significant difference between a single dose of 500 mg of Levofloxacin administered one hour before the urodynamic study and a once-daily dose of 500 mg of Levofloxacin for three days following the urodynamic study related to urinary tract infections prevention post-urodynamic examination.
- urinary tract infection
- urodynamic study
How to Cite
Rahardjo HE, Tirtayasa PMW, Afriansyah A, Parikesit D, Akbar MI. The Effectiveness of a Three Day Course Antibiotic Post-urodynamic Study in Preventing Lower Urinary Tract Infection. Acta Med Indones. 2016;48:84–90.
Dray E, Mueller ER. Use of Urodynamic Studies among Certifying and Recertifying Urologists from 2003 to 2014. Urol. Pract. 2017;4:251–6.
Kumalawati J, Handimulya D, Solin R. Bacterial and Antibiotics Susceptibility Profile at Cipto Mangunkusumo General Hospital January-June 2020. Kumalawati J, Handimulya D, Solin R, editors. Jakarta: Department of Clinical Pathology Cipto Mangunkusumo General Hospital; 2020. 147–153 p.
Copcoat MJ, Reed C, Cumming J, Shah PJR, Worth PHL. Is Antibiotic Prophylaxis Necessary for Routine Urodynamic Investigations?: A Controlled Study in 100 Patients. Br. J. Urol. 1988;61:302–3.
Kartal ED, Yenilmez A, Kiremitci A, Meric H, Kale M, Usluer G. Effectiveness of ciprofloxacin prophylaxis in preventing bacteriuria caused by urodynamic study: A blind, randomized study of 192 patients. Urology. 2006;67:1149–53.
Peschers UM, Kempf V, Jundt K, Autenrieth I, Dimpfl T. Antibiotic treatment to prevent urinary tract infections after urodynamic evaluation. Int Urogynecol J. 2001;12:254–7.
Siracusano S, Knez R, Tiberio A, Alfano V, Giannantoni A, Pappagallo G. The usefulness of antibiotic prophylaxis in invasive urodynamics in postmenopausal female subjects. Int Urogynecol J. 2008;19:939–42.
Westen EHMN, Kolk PR, Van Velzen CL, Unkels R, Mmuni NS, Hamisi AD, et al. Single-dose compared with multiple day antibiotic prophylaxis for cesarean section in low-resource settings, a randomized controlled, noninferiority trial. Acta Obstet Gynecol Scand. 2015;94:43–9.
Duff P. Antibiotic selection in obstetrics: Making cost-effective choices. Clin Obstet Gynecol. 2002;45:59–72.
Esposito S. Is single-dose antibiotic prophylaxis sufficient for any surgical procedure?. J Chemother. 1999;11(6):556–64.
Slobogean GP, O’Brien PJ, Brauer CA. Single-dose versus multiple-dose antibiotic prophylaxis for the surgical treatment of closed fractures. Acta Orthopaedica. 2010;81:256–62.
Tamayo E, Gualis J, Flórez S, Castrodeza J, Eiros Bouza JM, Álvarez FJ. Comparative study of single-dose and 24-hour multiple-dose antibiotic prophylaxis for cardiac surgery. J. Thorac. Cardiovasc. Surg.. 2008;136:1522–7.
Davey P, Scott CL, Brown E, Charani E, Michie S, Ramsay CR, et al. Interventions to improve antibiotic prescribing practices for hospital inpatients (updated protocol). Cochrane Database of Systematic Reviews. 2017.
R. Foon, P. Toozs-Hobson, and P. Latthe, “Prophylactic antibiotics to reduce the risk of urinary tract infections after urodynamic studies,” Cochrane Database of Systematic Reviews, vol. 10, p. CD008224, 2012.
Latthe, P. M., Foon, R., & Toozs‐Hobson, P. Prophylactic antibiotics in urodynamics: a systematic review of effectiveness and safety. Neurourol Urodyn. 2008;27:167-173.
Okorocha I, Cumming G, Gould I. Female urodynamics and lower urinary tract infection. BJU Int. 2002;89:863-7
Onur R, Ozden M, Orhan I, et al. Incidence of bacteraemia after urodynamic study. J Hosp Infect. 2004;57:241-4.
L. Bombieri, D. A. Dance, G. W. Rienhardt, A. Waterfield, and R. M. Freeman, “Urinary tract infection after urodynamic studies in women: incidence and natural history,” BJU Int. 1999;83:392–5
Ghanbari, Z., Haghollahi, F., Eftekhr, T., Froghifar, T., Shariat, M., Hajihashemy, M., & Ayati, M. Rate of urinary tract infection after urodynamic study in pelvic floor clinic. Caspian J Intern Med. 2020;11:100.
Nóbrega, M. M., Auge, A. P. F., de Toledo, L. G. M., da Silva Carramão, S., Frade, A. B., & Salles, M. J. C. Bacteriuria and urinary tract infection after female urodynamic studies: risk factors and microbiological analysis. Am J Infect Control. 2015;43:1035-39.
Cutinha PE, Potts LK, Fleet C. Morbidity following pressure flow studies (PFS). Are prophylactic antibiotics necessary? Neurourol Urodyn. 1996;15:304-5.
Baker KR, Drutz HP, Barnes MD. Effectiveness of antibiotic prophylaxis in preventing bacteriuria after multichannel urodynamic investigations: a blind, randomized study in 124 female patients. Am J Obstet Gynecol. 1991;165:679-81.
Payne SR, Timoney AG, McKenning ST et al. Microbiological look at urodynamic studies. Lancet 1988;2:1123–1126
Thodthasri, T., Chetchotisakd, P., Kharmwan, S., & Anunnatsiri, S. Antibiotic Prophylaxis Prior to Urodynamic Study in Patients with Neurogenic Bladder and Asymptomatic Bacteriuria: A Randomized Controlled Trial. J Med Assoc Thai. 2021;104:56-62.
Wolf JS, Bennett CJ, Dmochowski RR, Hollenbeck BK, Pearle MS, Schaeffer AJ. Best Practice Policy Statement on Urologic Surgery Antimicrobial Prophylaxis. J Urol. 2008;179:1379–90.
Nadeem M, Sheikh MI, Sait MS, Emmanuel N, Sheriff MK, Masood S. Is urinary tract infection after urodynamic study predictable?. Urol. Sci.. 2017;28:240-2.
Barie PS. Modern surgical antibiotic prophylaxis and therapy--less is more. Surg Infect. 2000;1:23–9.
DiPiro JT, Cheung RPF, Bowden TA, Mansberger JA. Single dose systemic antibiotic prophylaxis of surgical wound infections. Am. J. Surg. 1986;152:552-9.
Carbón C. Single‐Dose Antibiotic Therapy: What Has the Past Taught Us? J. Clin. Pharmacol.. 1992;32:686–91.
Wu XY, Cheng Y, Xu SF, Ling Q, Yuan XY, Du GH. Prophylactic Antibiotics for Urinary Tract Infections after Urodynamic Studies: A Meta-Analysis. Biomed Res. Int.. 2021.
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