ISSN: 1735-1308
March-April 2022
Vol. 19 No. 02 (2022)
Medium-Term Outcomes of COVID-19 Infection After Kidney Transplantation for Ongoing Living and Deceased Kidney Transplantations within the COVID-19 Pandemic
Urology Journal,
Vol. 19 No. 02 (2022),
,
Page 126-130
https://doi.org/10.22037/uj.v18i.6930
Abstract
Objectives: To present the early to midterm experience of two referral kidney transplantation centers with living and deceased kidney transplantations that were performed within the COVID-19 pandemic.
Materials and Methods: All cases performed in two referral centers in Iran within the COVID-19 pandemic
were investigated. Transplantations were performed from May 2020 to February 2021. The protocol for screening included nasopharyngeal RT-PCR with chest CT scan for living and deceased transplantations in center A and RTPCR for living transplantations and chest CT scan for deceased transplantations in center B. Patients were followed for 14-26 months after transplantation regarding COVID-19 infection and its outcomes in case of infection.
Results: 103 kidney transplantations were performed during the study period including 54 (52.4%) living and 49
(47.6%) deceased kidney transplantations. Twenty-four recipients (23.3%) and a living donor (1%) were infected
with COVID-19. The severity of COVID-19 infection was mild, moderate, severe, and critical in 16 (66.6%), 4
(16.6%), 2 (8.4%), and 2 patients (8.4%), respectively. Two mortalities were observed within transplantation recipients with COVID-19 infection (1.9%). 87.5% (7/8) COVID-19 infections in center B were observed in recipients of deceased transplantations who were screened only by chest CT scan.
Conclusion: The results of this study indicate a low frequency of COVID-19 mortality (1.9% for the whole cohort
and 8.3% within COVID-19 infected patients) for recipients of living and deceased kidney transplantation that
were performed within the COVID-19 pandemic. The above findings highlight for the first time in a large study
the probability of living kidney transplantation during the COVID-19 pandemic in case strict screening of donors
and recipients and close supervision of operating rooms and wards are implemented. We further hypothesize the inadequacy of chest CT scan for screening of COVID-19 in kidney transplantation surgery candidates.
- kidney transplantation; COVID-19 pandemic; Living transplantation; cadaveric transplantation; rt-PCR COVID-19 test; chest CT scan
How to Cite
References
Craig-Schapiro R, Salinas T, Lubetzky M, Abel BT, Sultan S. COVID-19 outcomes in patients waitlisted for kidney transplantation and kidney transplant recipients. Am J Transplant.2020.
Abrishami A, Samavat S, Behnam B, Arab-Ahmadi M, Nafar M, Sanei Taheri M. Clinical Course, Imaging Features, and Outcomes of COVID-19 in Kidney Transplant Recipients. Eur Urol. 2020;78:281-6.
Rodrigo E, Miñambres E. COVID-19-related collapse of transplantation systems: A heterogeneous recovery? Am J Transplant. 2020;20:3265-6.
Simforoosh N, Basiri A, Tabibi A, Javanmard B, Kashi AH, Soltani MH, et al. Living Unrelated Versus Related Kidney Transplantation: A 25-Year Experience with 3716 Cases. Urol J. 2016;13:2546-51.
Clarke C, Lucisano G, Prendecki M, Gleeson S, Martin P, Ali M, et al. Informing the Risk of Kidney Transplantation Versus Remaining on the Waitlist in the Coronavirus Disease 2019 Era. Kidney Int Rep. 2021;6:46-55.
Montagud-Marrahi E, Cofan F, Torregrosa JV, Cucchiari D, Ventura-Aguiar P, Revuelta I, et al. Preliminary data on outcomes of SARS-CoV-2 infection in a Spanish single center cohort of kidney recipients. Am J Transplant. 2020;20:2958-9.
Cravedi P, Mothi SS, Azzi Y, Haverly M, Farouk SS. COVID-19 and kidney transplantation: Results from the TANGO International Transplant Consortium. Am J Transplant. 2020;20:3140-8.
Pascual J, Melilli E, Jiménez-Martín C, González-Monte E, Zárraga S, Gutiérrez-Dalmau A, et al. COVID-19-related Mortality During the First 60 Days After Kidney Transplantation. Eur Urol. 2020;78:641-3.
Mahalingasivam V, Craik A, Tomlinson LA, Ge L, Hou L, Wang Q, et al. A Systematic Review of COVID-19 and Kidney Transplantation. Kidney Int Rep. 2021;6:24-45.
Basiri A, Zafarghandi M, Golshan S, Eshrati B, Fattahi A, Kashi AH. COVID-19 Infection and Mortality Rates within Medical Specialists and General Practitioners and Its Comparison with the General Population: A Longitudinal Nationwide Study. Iran J Public Health. 2021;50:1421-7.
Ghahestani SM, Kashi AH. Guidelines for Urological Surgeries in the COVID-19 Pandemic: Is it Time for Revision? Urol J. 2021;17:560-1.
Horby P, Lim WS, Emberson JR, Mafham M, Bell JL, Linsell L, et al. Dexamethasone in Hospitalized Patients with Covid-19. New Eng J Med. 2021;384:693-704.
Kataria A, Yakubu I, Winstead R, Gowda M, Gupta G. COVID-19 in Kidney Transplantation: Epidemiology, Management Considerations, and the Impact on Kidney Transplant Practice. Transplantation direct. 2020;6:e582.
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