An Update on Biochemical and Genomic Markers for Prostate Cancer Biochemical and Genomic Markers for Prostate Cancer
Urology Journal,
,
23 February 2021
,
Page 6828
https://doi.org/10.22037/uj.v18i.6828
Abstract
Purpose: Detecting prostate cancer, developing therapeutic plans after negative biopsies, and prognosis-based patient counseling can be challenging for many urologists dealing with prostate cancer-specific antigens. New Biomarkers advances made improvement for prediction of responses to therapeutic option and can tell us about survival and recurrence. In this review, we have assessed current and upcoming biomarkers that are opening a new era in diagnosing the disease.Materials and Methods: We conducted a comprehensive literature review of studies describing prostate cancer biomarkers. Two independent investigators searched PubMed, Embase, Web of Science, and Cochrane Databases to identify biomarkers in prostate cancer conducted a literature review.
Results: Recently, combining prostate cancer-specific biomarkers into a single test has gained increasing attention, especially since the introduction of genomic and molecular tools. The development of the Prostate Health Index (PHI), SelectMDx, and Confirm MDx have shown promising results for prostate cancer detection, in addition to risk stratification and biopsy avoidance. Conclusion: Despite major improvements and innovations in prostate cancer biomarkers, application in current clinical practice is limited. However, these biomarkers have an important role in determining risk, preventing unnecessary prostate biopsies, and predicting prognoses. Additional confirmatory studies will be needed to fully understand the impact of prostate cancer-specific biomarkers.
Keywords:
- Prostate cancer, Biomarkers, Genetic test, diagnosis, prognosis
How to Cite
Falahatkar, R. ., Mokhtari, G., Momeni-Moghaddam , M., Teimoori, M., Baghani Aal , H., Akhavan, A. ., Falahatkar, S., & Esmaeili, S. (2021). An Update on Biochemical and Genomic Markers for Prostate Cancer: Biochemical and Genomic Markers for Prostate Cancer. Urology Journal, 18, 6828. https://doi.org/10.22037/uj.v18i.6828
References
Wong MC, Goggins WB, Wang HH, Fung FD, Leung C, Wong SY, Ng CF, Sung JJ (2016) Global Incidence and Mortality for Prostate Cancer: Analysis of Temporal Patterns and Trends in 36 Countries. European urology 70 (5):862-874. doi:10.1016/j.eururo.2016.05.043
2) Hayes JH, Barry MJ (2014) Screening for prostate cancer with the prostate-specific antigen test: a review of current evidence. Jama 311 (11):1143-1149. doi:10.1001/jama.2014.2085
3) McDonald ML, Parsons JK (2016) 4-Kallikrein Test and Kallikrein Markers in Prostate Cancer Screening. The Urologic clinics of North America 43 (1):39-46. doi:10.1016/j.ucl.2015.08.004
4) Sanchis-Bonet A, Barrionuevo-Gonzalez M, Bajo-Chueca A, Morales-Palacios N, Sanchez-Chapado M (2018) Does [-2]Pro-Prostate Specific Antigen Meet the Criteria to Justify Its Inclusion in the Clinical Decision-Making Process? Urologia internationalis. doi:10.1159/000481439
5) Vickers AJ, Cronin AM, Aus G, Pihl CG, Becker C, Pettersson K, Scardino PT, Hugosson J, Lilja H (2008) A panel of kallikrein markers can reduce unnecessary biopsy for prostate cancer: data from the European Randomized Study of Prostate Cancer Screening in Goteborg, Sweden. BMC medicine 6:19. doi:10.1186/1741-7015-6-19
6) Lin DW, Newcomb LF, Brown MD, Sjoberg DD, Dong Y, Brooks JD, Carroll PR, Cooperberg M, Dash A, Ellis WJ, Fabrizio M, Gleave ME, Morgan TM, Nelson PS, Thompson IM, Wagner AA, Zheng Y (2017) Evaluating the Four Kallikrein Panel of the 4Kscore for Prediction of High-grade Prostate Cancer in Men in the Canary Prostate Active Surveillance Study. European urology 72 (3):448-454. doi:10.1016/j.eururo.2016.11.017
7) Loeb S, Catalona WJ (2014) The Prostate Health Index: a new test for the detection of prostate cancer. Therapeutic advances in urology 6 (2):74-77. doi:10.1177/1756287213513488
8) Tosoian JJ, Druskin SC, Andreas D, Mullane P, Chappidi M, Joo S, Ghabili K, Mamawala M, Agostino J, Carter HB, Partin AW, Sokoll LJ, Ross AE (2017) Prostate Health Index density improves detection of clinically significant prostate cancer. BJU international 120 (6):793-798. doi:10.1111/bju.13762
9) Russo GI, Regis F, Castelli T, Favilla V, Privitera S, Giardina R, Cimino S, Morgia G (2017) A Systematic Review and Meta-analysis of the Diagnostic Accuracy of Prostate Health Index and 4-Kallikrein Panel Score in Predicting Overall and High-grade Prostate Cancer. Clinical genitourinary cancer 15 (4):429-439 e421. doi:10.1016/j.clgc.2016.12.022
10) Lenzo NP, Meyrick D, Turner JH (2018) Review of Gallium-68 PSMA PET/CT Imaging in the Management of Prostate Cancer. Diagnostics (Basel) 8 (1). doi:10.3390/diagnostics8010016
11) Ceci F, Castellucci P, Cerci JJ, Fanti S (2017) New aspects of molecular imaging in prostate cancer. Methods 130:36-41. doi:10.1016/j.ymeth.2017.07.009
12) Muthumani K, Marnin L, Kudchodkar SB, Perales-Puchalt A, Choi H, Agarwal S, Scott VL, Reuschel EL, Zaidi FI, Duperret EK, Wise MC, Kraynyak KA, Ugen KE, Sardesai NY, Joseph Kim J, Weiner DB (2017) Novel prostate cancer immunotherapy with a DNA-encoded anti-prostate-specific membrane antigen monoclonal antibody. Cancer immunology, immunotherapy : CII 66 (12):1577-1588. doi:10.1007/s00262-017-2042-7
13) Zheng K, Dou Y, He L, Li H, Zhang Z, Chen Y, Ye A, Liu W, Kong L (2015) Improved sensitivity and specificity for prostate cancer diagnosis based on the urine PCA3/PSA ratio acquired by sequencespecific RNA capture. Oncology reports 34 (5):2439-2444. doi:10.3892/or.2015.4266
14) Ferro M, Buonerba C, Terracciano D, Lucarelli G, Cosimato V, Bottero D, Deliu VM, Ditonno P, Perdona S, Autorino R, Coman I, De Placido S, Di Lorenzo G, De Cobelli O (2016) Biomarkers in localized prostate cancer. Future Oncol 12 (3):399-411. doi:10.2217/fon.15.318
15) Cui Y, Cao W, Li Q, Shen H, Liu C, Deng J, Xu J, Shao Q (2016) Evaluation of prostate cancer antigen 3 for detecting prostate cancer: a systematic review and meta-analysis. Scientific reports 6:25776. doi:10.1038/srep25776
16) Hegde JV, Veruttipong D, Said JW, Reiter RE, Steinberg ML, King CR, Kishan AU (2017) Prostate Cancer Antigen 3 Score Does Not Predict for Adverse Pathologic Features at Radical Prostatectomy or for Progression-free Survival in Clinically Localized, Intermediate- and High-risk Prostate Cancer. Urology 107:171-177. doi:10.1016/j.urology.2017.05.028
17) Sedarsky J, Degon M, Srivastava S, Dobi A (2017) Ethnicity and ERG frequency in prostate cancer. Nature reviews Urology. doi:10.1038/nrurol.2017.140
18) Adamo P, Ladomery MR (2016) The oncogene ERG: a key factor in prostate cancer. Oncogene 35 (4):403-414. doi:10.1038/onc.2015.109
19) Zhou CK, Young D, Yeboah ED, Coburn SB, Tettey Y, Biritwum RB, Adjei AA, Tay E, Niwa S, Truelove A, Welsh J, Mensah JE, Hoover RN, Sesterhenn IA, Hsing AW, Srivastava S, Cook MB (2017) TMPRSS2:ERG Gene Fusions in Prostate Cancer of West African Men and a Meta-Analysis of Racial Differences. American journal of epidemiology 186 (12):1352-1361. doi:10.1093/aje/kwx235
20) Pan J, Ding M, Xu K, Yang C, Mao LJ (2017) Exosomes in diagnosis and therapy of prostate cancer. Oncotarget 8 (57):97693-97700. doi:10.18632/oncotarget.18532
21) Dijkstra S, Birker IL, Smit FP, Leyten GH, de Reijke TM, van Oort IM, Mulders PF, Jannink SA, Schalken JA (2014) Prostate cancer biomarker profiles in urinary sediments and exosomes. The Journal of urology 191 (4):1132-1138. doi:10.1016/j.juro.2013.11.001
22) Donovan MJ, Noerholm M, Bentink S, Belzer S, Skog J, O'Neill V, Cochran JS, Brown GA (2015) A molecular signature of PCA3 and ERG exosomal RNA from non-DRE urine is predictive of initial prostate biopsy result. Prostate cancer and prostatic diseases 18 (4):370-375. doi:10.1038/pcan.2015.40
23) McKiernan J, Donovan MJ, O'Neill V, Bentink S, Noerholm M, Belzer S, Skog J, Kattan MW, Partin A, Andriole G, Brown G, Wei JT, Thompson IM, Jr., Carroll P (2016) A Novel Urine Exosome Gene Expression Assay to Predict High-grade Prostate Cancer at Initial Biopsy. JAMA oncology 2 (7):882-889. doi:10.1001/jamaoncol.2016.0097
24) Nguyen PL, Haddad Z, Ross AE, Martin NE, Deheshi S, Lam LLC, Chelliserry J, Tosoian JJ, Lotan TL, Spratt DE, Stoyanova RS, Punnen S, Ong K, Buerki C, Aranes M, Kolisnik T, Margrave J, Yousefi K, Choeurng V, Davicioni E, Trock BJ, Kane CJ, Pollack A, Davis JW, Feng FY, Klein EA (2017) Ability of a Genomic Classifier to Predict Metastasis and Prostate Cancer-specific Mortality after Radiation or Surgery based on Needle Biopsy Specimens. European urology 72 (5):845-852. doi:10.1016/j.eururo.2017.05.009
25) McGrath S, Christidis D, Perera M, Hong SK, Manning T, Vela I, Lawrentschuk N (2016) Prostate cancer biomarkers: Are we hitting the mark? Prostate international 4 (4):130-135. doi:10.1016/j.prnil.2016.07.002
26) Dijkstra S, Govers TM, Hendriks RJ, Schalken JA, Van Criekinge W, Van Neste L, Grutters JPC, Sedelaar JPM, van Oort IM (2017) Cost-effectiveness of a new urinary biomarker-based risk score compared to standard of care in prostate cancer diagnostics - a decision analytical model. BJU international 120 (5):659-665. doi:10.1111/bju.13861
27) Mohler JL, Armstrong AJ, Bahnson RR, D'Amico AV, Davis BJ, Eastham JA, Enke CA, Farrington TA, Higano CS, Horwitz EM (2016) Prostate cancer, version 1.2016. Journal of the National Comprehensive Cancer Network 14 (1):19-30
28) Gaudreau PO, Stagg J, Soulieres D, Saad F (2016) The Present and Future of Biomarkers in Prostate Cancer: Proteomics, Genomics, and Immunology Advancements. Biomarkers in cancer 8 (Suppl 2):15-33. doi:10.4137/BIC.S31802
29) Knezevic D, Goddard AD, Natraj N, Cherbavaz DB, Clark-Langone KM, Snable J, Watson D, Falzarano SM, Magi-Galluzzi C, Klein EA, Quale C (2013) Analytical validation of the Oncotype DX prostate cancer assay - a clinical RT-PCR assay optimized for prostate needle biopsies. BMC genomics 14:690. doi:10.1186/1471-2164-14-690
30) Crawford ED, Scholz MC, Kar AJ, Fegan JE, Haregewoin A, Kaldate RR, Brawer MK (2014) Cell cycle progression score and treatment decisions in prostate cancer: results from an ongoing registry. Current medical research and opinion 30 (6):1025-1031. doi:10.1185/03007995.2014.899208
31) Prolaris Cell Cycle Progression Test for Localized Prostate Cancer: A Health Technology Assessment (2017). Ontario health technology assessment series 17 (6):1-75
32) Ozdemir BC, Siefker-Radtke AO, Campbell MT, Subudhi SK (2017) Current and Future Applications of Novel Immunotherapies in Urological Oncology: A Critical Review of the Literature. European urology focus. doi:10.1016/j.euf.2017.10.001
33) Morgan R, El-Tanani M, Hunter KD, Harrington KJ, Pandha HS (2017) Targeting HOX/PBX dimers in cancer. Oncotarget 8 (19):32322-32331. doi:10.18632/oncotarget.15971
34) Gansmo LB, Vatten L, Romundstad P, Hveem K, Ryan BM, Harris CC, Knappskog S, Lonning PE (2016) Associations between the MDM2 promoter P1 polymorphism del1518 (rs3730485) and incidence of cancer of the breast, lung, colon and prostate. Oncotarget 7 (19):28637-28646. doi:10.18632/oncotarget.8705
35) Benafif S, Eeles R (2016) Genetic predisposition to prostate cancer. British medical bulletin 120 (1):75-89. doi:10.1093/bmb/ldw039
36) Ferro M, Ungaro P, Cimmino A, Lucarelli G, Busetto GM, Cantiello F, Damiano R, Terracciano D (2017) Epigenetic Signature: A New Player as Predictor of Clinically Significant Prostate Cancer (PCa) in Patients on Active Surveillance (AS). International journal of molecular sciences 18 (6). doi:10.3390/ijms18061146
37) Steiner I, Jung K, Schatz P, Horns T, Wittschieber D, Lein M, Dietel M, Erbersdobler A (2010) Gene promoter methylation and its potential relevance in early prostate cancer diagnosis. Pathobiology : journal of immunopathology, molecular and cellular biology 77 (5):260-266. doi:10.1159/000318017
38) Wojno KJ, Costa FJ, Cornell RJ, Small JD, Pasin E, Van Criekinge W, Bigley JW, Van Neste L (2014) Reduced Rate of Repeated Prostate Biopsies Observed in ConfirmMDx Clinical Utility Field Study. American health & drug benefits 7 (3):129-134
39) Tsourlakis MC, Eleftheriadou A, Stender A, Weigand P, Grupp K, Hube-Magg C, Kluth M, Schroeder C, Steurer S, Hinsch A, Luebke A, Angerer A, Wittmer C, Friedrich E, Gobel C, Buscheck F, Heinzer H, Graefen M, Simon R, Sauter G, Wilczak W, Minner S, Schlomm T, Jacobsen F (2017) FOXA1 expression is a strong independent predictor of early PSA recurrence in ERG negative prostate cancers treated by radical prostatectomy. Carcinogenesis 38 (12):1180-1187. doi:10.1093/carcin/bgx105
40) Djavan B, Eastham J, Gomella L, Tombal B, Taneja S, Dianat SS, Kazzazi A, Shore N, Abrahamsson PA, Cheetham P, Moul J, Lepor H, Crawford ED (2012) Testosterone in prostate cancer: the Bethesda consensus. BJU international 110 (3):344-352. doi:10.1111/j.1464-410X.2011.10719.x
41) Hettel D, Sharifi N (2017) HSD3B1 status as a biomarker of androgen deprivation resistance and implications for prostate cancer. Nature reviews Urology. doi:10.1038/nrurol.2017.201
42) Grindstad T, Skjefstad K, Andersen S, Ness N, Nordby Y, Al-Saad S, Fismen S, Donnem T, Khanehkenari MR, Busund LT, Bremnes RM, Richardsen E (2016) Estrogen receptors alpha and beta and aromatase as independent predictors for prostate cancer outcome. Scientific reports 6:33114. doi:10.1038/srep33114
43) Horning AM, Wang Y, Lin CK, Louie AD, Jadhav RR, Hung CN, Wang CM, Lin CL, Kirma NB, Liss MA, Kumar AP, Sun L, Liu Z, Chao WT, Wang Q, Jin VX, Chen CL, Huang TH (2017) Single-cell RNA-seq reveals a subpopulation of prostate cancer cells with enhanced cell cycle-related transcription and attenuated androgen response. Cancer research. doi:10.1158/0008-5472.CAN-17-1924
44) Baena-Del Valle JA, Zheng Q, Esopi DM, Rubenstein M, Hubbard GK, Moncaliano MC, Hruszkewycz A, Vaghasia A, Yegnasubramanian S, Wheelan SJ, Meeker AK, Heaphy CM, Graham MK, De Marzo AM (2018) MYC drives overexpression of telomerase RNA (hTR/TERC) in prostate cancer. The Journal of pathology 244 (1):11-24. doi:10.1002/path.4980
45) Cheng HH, Plets M, Li H, Higano CS, Tangen CM, Agarwal N, Vogelzang NJ, Hussain M, Thompson IM, Jr., Tewari M, Yu EY (2018) Circulating microRNAs and treatment response in the Phase II SWOG S0925 study for patients with new metastatic hormone-sensitive prostate cancer. The Prostate 78 (2):121-127. doi:10.1002/pros.23452
46) Fu F, Wan X, Wang D, Kong Z, Zhang Y, Huang W, Wang C, Wu H, Li Y (2018) MicroRNA-19a acts as a prognostic marker and promotes prostate cancer progression via inhibiting VPS37A expression. Oncotarget 9 (2):1931-1943. doi:10.18632/oncotarget.23026
47) Feng S, Qian X, Li H, Zhang X (2017) Combinations of elevated tissue miRNA-17-92 cluster expression and serum prostate-specific antigen as potential diagnostic biomarkers for prostate cancer. Oncology letters 14 (6):6943-6949. doi:10.3892/ol.2017.7026
48) Liu L, Guo K, Liang Z, Li F, Wang H (2018) Identification of candidate genes that may contribute to the metastasis of prostate cancer by bioinformatics analysis. Oncology letters 15 (1):1220-1228. doi:10.3892/ol.2017.7404
49) Dhawan M, Ryan CJ, Ashworth A (2016) DNA Repair Deficiency Is Common in Advanced Prostate Cancer: New Therapeutic Opportunities. The oncologist 21 (8):940-945. doi:10.1634/theoncologist.2016-0135
50) Cheng HH, Pritchard CC, Montgomery B, Lin DW, Nelson PS (2017) Prostate Cancer Screening in a New Era of Genetics. Clinical genitourinary cancer 15 (6):625-628. doi:10.1016/j.clgc.2017.05.024
51) Zhao SG, Chang SL, Spratt DE, Erho N, Yu M, Ashab HA, Alshalalfa M, Speers C, Tomlins SA, Davicioni E, Dicker AP, Carroll PR, Cooperberg MR, Freedland SJ, Karnes RJ, Ross AE, Schaeffer EM, Den RB, Nguyen PL, Feng FY (2016) Development and validation of a 24-gene predictor of response to postoperative radiotherapy in prostate cancer: a matched, retrospective analysis. The Lancet Oncology 17 (11):1612-1620. doi:10.1016/S1470-2045(16)30491-0
52) Shipitsin M, Small C, Choudhury S, Giladi E, Friedlander S, Nardone J, Hussain S, Hurley AD, Ernst C, Huang YE, Chang H, Nifong TP, Rimm DL, Dunyak J, Loda M, Berman DM, Blume-Jensen P (2014) Identification of proteomic biomarkers predicting prostate cancer aggressiveness and lethality despite biopsy-sampling error. British journal of cancer 111 (6):1201-1212. doi:10.1038/bjc.2014.396
53) Lennartz M, Minner S, Brasch S, Wittmann H, Paterna L, Angermeier K, Ozturk E, Shihada R, Ruge M, Kluth M, Koop C, Wilczak W, Krech T, Lebok P, Wittmer C, Heinzer H, Steuber T, Adam M, Huland H, Graefen M, Haese A, Simon R, Sauter G, Schlomm T (2016) The Combination of DNA Ploidy Status and PTEN/6q15 Deletions Provides Strong and Independent Prognostic Information in Prostate Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research 22 (11):2802-2811. doi:10.1158/1078-0432.CCR-15-0635
54) Parimi S, Ko JJ (2017) Recent advances in circulating tumor cells and cell-free DNA in metastatic prostate cancer: a review. Expert review of anticancer therapy 17 (10):939-949. doi:10.1080/14737140.2017.1359544
55) Markou A, Lazaridou M, Paraskevopoulos P, Chen S, Swierczewska M, Budna J, Kuske A, Gorges TM, Joosse SA, Kroneis T, Zabel M, Sedlmayr P, Alix-Panabieres C, Pantel K, Lianidou ES (2017) Multiplex Gene Expression Profiling of In Vivo Isolated Circulating Tumor Cells in High-Risk Prostate Cancer Patients. Clinical chemistry. doi:10.1373/clinchem.2017.275503
56) Djavan B, Nelson K, Kazzazi A, Bruhn A, Sadri H, Gomez-Pinillos A, Ferrari AC (2011) Immunotherapy in the treatment of advanced prostate cancer. The Canadian journal of urology 18 (5):5865-5874
57) Garcia JL, Lozano R, Misiewicz-Krzeminska I, Fernandez-Mateos J, Krzeminski P, Alfonso S, Marcos RA, Garcia R, Gomez-Veiga F, Virseda A, Herrero M, Olmos D, Cruz-Hernandez JJ (2017) A novel capillary nano-immunoassay for assessing androgen receptor splice variant 7 in plasma. Correlation with CD133 antigen expression in circulating tumor cells. A pilot study in prostate cancer patients. Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 19 (11):1350-1357. doi:10.1007/s12094-017-1675-5
58) Seitz AK, Thoene S, Bietenbeck A, Nawroth R, Tauber R, Thalgott M, Schmid S, Secci R, Retz M, Gschwend JE, Ruland J, Winter C, Heck MM (2017) AR-V7 in Peripheral Whole Blood of Patients with Castration-resistant Prostate Cancer: Association with Treatment-specific Outcome Under Abiraterone and Enzalutamide. European urology 72 (5):828-834. doi:10.1016/j.eururo.2017.07.024
2) Hayes JH, Barry MJ (2014) Screening for prostate cancer with the prostate-specific antigen test: a review of current evidence. Jama 311 (11):1143-1149. doi:10.1001/jama.2014.2085
3) McDonald ML, Parsons JK (2016) 4-Kallikrein Test and Kallikrein Markers in Prostate Cancer Screening. The Urologic clinics of North America 43 (1):39-46. doi:10.1016/j.ucl.2015.08.004
4) Sanchis-Bonet A, Barrionuevo-Gonzalez M, Bajo-Chueca A, Morales-Palacios N, Sanchez-Chapado M (2018) Does [-2]Pro-Prostate Specific Antigen Meet the Criteria to Justify Its Inclusion in the Clinical Decision-Making Process? Urologia internationalis. doi:10.1159/000481439
5) Vickers AJ, Cronin AM, Aus G, Pihl CG, Becker C, Pettersson K, Scardino PT, Hugosson J, Lilja H (2008) A panel of kallikrein markers can reduce unnecessary biopsy for prostate cancer: data from the European Randomized Study of Prostate Cancer Screening in Goteborg, Sweden. BMC medicine 6:19. doi:10.1186/1741-7015-6-19
6) Lin DW, Newcomb LF, Brown MD, Sjoberg DD, Dong Y, Brooks JD, Carroll PR, Cooperberg M, Dash A, Ellis WJ, Fabrizio M, Gleave ME, Morgan TM, Nelson PS, Thompson IM, Wagner AA, Zheng Y (2017) Evaluating the Four Kallikrein Panel of the 4Kscore for Prediction of High-grade Prostate Cancer in Men in the Canary Prostate Active Surveillance Study. European urology 72 (3):448-454. doi:10.1016/j.eururo.2016.11.017
7) Loeb S, Catalona WJ (2014) The Prostate Health Index: a new test for the detection of prostate cancer. Therapeutic advances in urology 6 (2):74-77. doi:10.1177/1756287213513488
8) Tosoian JJ, Druskin SC, Andreas D, Mullane P, Chappidi M, Joo S, Ghabili K, Mamawala M, Agostino J, Carter HB, Partin AW, Sokoll LJ, Ross AE (2017) Prostate Health Index density improves detection of clinically significant prostate cancer. BJU international 120 (6):793-798. doi:10.1111/bju.13762
9) Russo GI, Regis F, Castelli T, Favilla V, Privitera S, Giardina R, Cimino S, Morgia G (2017) A Systematic Review and Meta-analysis of the Diagnostic Accuracy of Prostate Health Index and 4-Kallikrein Panel Score in Predicting Overall and High-grade Prostate Cancer. Clinical genitourinary cancer 15 (4):429-439 e421. doi:10.1016/j.clgc.2016.12.022
10) Lenzo NP, Meyrick D, Turner JH (2018) Review of Gallium-68 PSMA PET/CT Imaging in the Management of Prostate Cancer. Diagnostics (Basel) 8 (1). doi:10.3390/diagnostics8010016
11) Ceci F, Castellucci P, Cerci JJ, Fanti S (2017) New aspects of molecular imaging in prostate cancer. Methods 130:36-41. doi:10.1016/j.ymeth.2017.07.009
12) Muthumani K, Marnin L, Kudchodkar SB, Perales-Puchalt A, Choi H, Agarwal S, Scott VL, Reuschel EL, Zaidi FI, Duperret EK, Wise MC, Kraynyak KA, Ugen KE, Sardesai NY, Joseph Kim J, Weiner DB (2017) Novel prostate cancer immunotherapy with a DNA-encoded anti-prostate-specific membrane antigen monoclonal antibody. Cancer immunology, immunotherapy : CII 66 (12):1577-1588. doi:10.1007/s00262-017-2042-7
13) Zheng K, Dou Y, He L, Li H, Zhang Z, Chen Y, Ye A, Liu W, Kong L (2015) Improved sensitivity and specificity for prostate cancer diagnosis based on the urine PCA3/PSA ratio acquired by sequencespecific RNA capture. Oncology reports 34 (5):2439-2444. doi:10.3892/or.2015.4266
14) Ferro M, Buonerba C, Terracciano D, Lucarelli G, Cosimato V, Bottero D, Deliu VM, Ditonno P, Perdona S, Autorino R, Coman I, De Placido S, Di Lorenzo G, De Cobelli O (2016) Biomarkers in localized prostate cancer. Future Oncol 12 (3):399-411. doi:10.2217/fon.15.318
15) Cui Y, Cao W, Li Q, Shen H, Liu C, Deng J, Xu J, Shao Q (2016) Evaluation of prostate cancer antigen 3 for detecting prostate cancer: a systematic review and meta-analysis. Scientific reports 6:25776. doi:10.1038/srep25776
16) Hegde JV, Veruttipong D, Said JW, Reiter RE, Steinberg ML, King CR, Kishan AU (2017) Prostate Cancer Antigen 3 Score Does Not Predict for Adverse Pathologic Features at Radical Prostatectomy or for Progression-free Survival in Clinically Localized, Intermediate- and High-risk Prostate Cancer. Urology 107:171-177. doi:10.1016/j.urology.2017.05.028
17) Sedarsky J, Degon M, Srivastava S, Dobi A (2017) Ethnicity and ERG frequency in prostate cancer. Nature reviews Urology. doi:10.1038/nrurol.2017.140
18) Adamo P, Ladomery MR (2016) The oncogene ERG: a key factor in prostate cancer. Oncogene 35 (4):403-414. doi:10.1038/onc.2015.109
19) Zhou CK, Young D, Yeboah ED, Coburn SB, Tettey Y, Biritwum RB, Adjei AA, Tay E, Niwa S, Truelove A, Welsh J, Mensah JE, Hoover RN, Sesterhenn IA, Hsing AW, Srivastava S, Cook MB (2017) TMPRSS2:ERG Gene Fusions in Prostate Cancer of West African Men and a Meta-Analysis of Racial Differences. American journal of epidemiology 186 (12):1352-1361. doi:10.1093/aje/kwx235
20) Pan J, Ding M, Xu K, Yang C, Mao LJ (2017) Exosomes in diagnosis and therapy of prostate cancer. Oncotarget 8 (57):97693-97700. doi:10.18632/oncotarget.18532
21) Dijkstra S, Birker IL, Smit FP, Leyten GH, de Reijke TM, van Oort IM, Mulders PF, Jannink SA, Schalken JA (2014) Prostate cancer biomarker profiles in urinary sediments and exosomes. The Journal of urology 191 (4):1132-1138. doi:10.1016/j.juro.2013.11.001
22) Donovan MJ, Noerholm M, Bentink S, Belzer S, Skog J, O'Neill V, Cochran JS, Brown GA (2015) A molecular signature of PCA3 and ERG exosomal RNA from non-DRE urine is predictive of initial prostate biopsy result. Prostate cancer and prostatic diseases 18 (4):370-375. doi:10.1038/pcan.2015.40
23) McKiernan J, Donovan MJ, O'Neill V, Bentink S, Noerholm M, Belzer S, Skog J, Kattan MW, Partin A, Andriole G, Brown G, Wei JT, Thompson IM, Jr., Carroll P (2016) A Novel Urine Exosome Gene Expression Assay to Predict High-grade Prostate Cancer at Initial Biopsy. JAMA oncology 2 (7):882-889. doi:10.1001/jamaoncol.2016.0097
24) Nguyen PL, Haddad Z, Ross AE, Martin NE, Deheshi S, Lam LLC, Chelliserry J, Tosoian JJ, Lotan TL, Spratt DE, Stoyanova RS, Punnen S, Ong K, Buerki C, Aranes M, Kolisnik T, Margrave J, Yousefi K, Choeurng V, Davicioni E, Trock BJ, Kane CJ, Pollack A, Davis JW, Feng FY, Klein EA (2017) Ability of a Genomic Classifier to Predict Metastasis and Prostate Cancer-specific Mortality after Radiation or Surgery based on Needle Biopsy Specimens. European urology 72 (5):845-852. doi:10.1016/j.eururo.2017.05.009
25) McGrath S, Christidis D, Perera M, Hong SK, Manning T, Vela I, Lawrentschuk N (2016) Prostate cancer biomarkers: Are we hitting the mark? Prostate international 4 (4):130-135. doi:10.1016/j.prnil.2016.07.002
26) Dijkstra S, Govers TM, Hendriks RJ, Schalken JA, Van Criekinge W, Van Neste L, Grutters JPC, Sedelaar JPM, van Oort IM (2017) Cost-effectiveness of a new urinary biomarker-based risk score compared to standard of care in prostate cancer diagnostics - a decision analytical model. BJU international 120 (5):659-665. doi:10.1111/bju.13861
27) Mohler JL, Armstrong AJ, Bahnson RR, D'Amico AV, Davis BJ, Eastham JA, Enke CA, Farrington TA, Higano CS, Horwitz EM (2016) Prostate cancer, version 1.2016. Journal of the National Comprehensive Cancer Network 14 (1):19-30
28) Gaudreau PO, Stagg J, Soulieres D, Saad F (2016) The Present and Future of Biomarkers in Prostate Cancer: Proteomics, Genomics, and Immunology Advancements. Biomarkers in cancer 8 (Suppl 2):15-33. doi:10.4137/BIC.S31802
29) Knezevic D, Goddard AD, Natraj N, Cherbavaz DB, Clark-Langone KM, Snable J, Watson D, Falzarano SM, Magi-Galluzzi C, Klein EA, Quale C (2013) Analytical validation of the Oncotype DX prostate cancer assay - a clinical RT-PCR assay optimized for prostate needle biopsies. BMC genomics 14:690. doi:10.1186/1471-2164-14-690
30) Crawford ED, Scholz MC, Kar AJ, Fegan JE, Haregewoin A, Kaldate RR, Brawer MK (2014) Cell cycle progression score and treatment decisions in prostate cancer: results from an ongoing registry. Current medical research and opinion 30 (6):1025-1031. doi:10.1185/03007995.2014.899208
31) Prolaris Cell Cycle Progression Test for Localized Prostate Cancer: A Health Technology Assessment (2017). Ontario health technology assessment series 17 (6):1-75
32) Ozdemir BC, Siefker-Radtke AO, Campbell MT, Subudhi SK (2017) Current and Future Applications of Novel Immunotherapies in Urological Oncology: A Critical Review of the Literature. European urology focus. doi:10.1016/j.euf.2017.10.001
33) Morgan R, El-Tanani M, Hunter KD, Harrington KJ, Pandha HS (2017) Targeting HOX/PBX dimers in cancer. Oncotarget 8 (19):32322-32331. doi:10.18632/oncotarget.15971
34) Gansmo LB, Vatten L, Romundstad P, Hveem K, Ryan BM, Harris CC, Knappskog S, Lonning PE (2016) Associations between the MDM2 promoter P1 polymorphism del1518 (rs3730485) and incidence of cancer of the breast, lung, colon and prostate. Oncotarget 7 (19):28637-28646. doi:10.18632/oncotarget.8705
35) Benafif S, Eeles R (2016) Genetic predisposition to prostate cancer. British medical bulletin 120 (1):75-89. doi:10.1093/bmb/ldw039
36) Ferro M, Ungaro P, Cimmino A, Lucarelli G, Busetto GM, Cantiello F, Damiano R, Terracciano D (2017) Epigenetic Signature: A New Player as Predictor of Clinically Significant Prostate Cancer (PCa) in Patients on Active Surveillance (AS). International journal of molecular sciences 18 (6). doi:10.3390/ijms18061146
37) Steiner I, Jung K, Schatz P, Horns T, Wittschieber D, Lein M, Dietel M, Erbersdobler A (2010) Gene promoter methylation and its potential relevance in early prostate cancer diagnosis. Pathobiology : journal of immunopathology, molecular and cellular biology 77 (5):260-266. doi:10.1159/000318017
38) Wojno KJ, Costa FJ, Cornell RJ, Small JD, Pasin E, Van Criekinge W, Bigley JW, Van Neste L (2014) Reduced Rate of Repeated Prostate Biopsies Observed in ConfirmMDx Clinical Utility Field Study. American health & drug benefits 7 (3):129-134
39) Tsourlakis MC, Eleftheriadou A, Stender A, Weigand P, Grupp K, Hube-Magg C, Kluth M, Schroeder C, Steurer S, Hinsch A, Luebke A, Angerer A, Wittmer C, Friedrich E, Gobel C, Buscheck F, Heinzer H, Graefen M, Simon R, Sauter G, Wilczak W, Minner S, Schlomm T, Jacobsen F (2017) FOXA1 expression is a strong independent predictor of early PSA recurrence in ERG negative prostate cancers treated by radical prostatectomy. Carcinogenesis 38 (12):1180-1187. doi:10.1093/carcin/bgx105
40) Djavan B, Eastham J, Gomella L, Tombal B, Taneja S, Dianat SS, Kazzazi A, Shore N, Abrahamsson PA, Cheetham P, Moul J, Lepor H, Crawford ED (2012) Testosterone in prostate cancer: the Bethesda consensus. BJU international 110 (3):344-352. doi:10.1111/j.1464-410X.2011.10719.x
41) Hettel D, Sharifi N (2017) HSD3B1 status as a biomarker of androgen deprivation resistance and implications for prostate cancer. Nature reviews Urology. doi:10.1038/nrurol.2017.201
42) Grindstad T, Skjefstad K, Andersen S, Ness N, Nordby Y, Al-Saad S, Fismen S, Donnem T, Khanehkenari MR, Busund LT, Bremnes RM, Richardsen E (2016) Estrogen receptors alpha and beta and aromatase as independent predictors for prostate cancer outcome. Scientific reports 6:33114. doi:10.1038/srep33114
43) Horning AM, Wang Y, Lin CK, Louie AD, Jadhav RR, Hung CN, Wang CM, Lin CL, Kirma NB, Liss MA, Kumar AP, Sun L, Liu Z, Chao WT, Wang Q, Jin VX, Chen CL, Huang TH (2017) Single-cell RNA-seq reveals a subpopulation of prostate cancer cells with enhanced cell cycle-related transcription and attenuated androgen response. Cancer research. doi:10.1158/0008-5472.CAN-17-1924
44) Baena-Del Valle JA, Zheng Q, Esopi DM, Rubenstein M, Hubbard GK, Moncaliano MC, Hruszkewycz A, Vaghasia A, Yegnasubramanian S, Wheelan SJ, Meeker AK, Heaphy CM, Graham MK, De Marzo AM (2018) MYC drives overexpression of telomerase RNA (hTR/TERC) in prostate cancer. The Journal of pathology 244 (1):11-24. doi:10.1002/path.4980
45) Cheng HH, Plets M, Li H, Higano CS, Tangen CM, Agarwal N, Vogelzang NJ, Hussain M, Thompson IM, Jr., Tewari M, Yu EY (2018) Circulating microRNAs and treatment response in the Phase II SWOG S0925 study for patients with new metastatic hormone-sensitive prostate cancer. The Prostate 78 (2):121-127. doi:10.1002/pros.23452
46) Fu F, Wan X, Wang D, Kong Z, Zhang Y, Huang W, Wang C, Wu H, Li Y (2018) MicroRNA-19a acts as a prognostic marker and promotes prostate cancer progression via inhibiting VPS37A expression. Oncotarget 9 (2):1931-1943. doi:10.18632/oncotarget.23026
47) Feng S, Qian X, Li H, Zhang X (2017) Combinations of elevated tissue miRNA-17-92 cluster expression and serum prostate-specific antigen as potential diagnostic biomarkers for prostate cancer. Oncology letters 14 (6):6943-6949. doi:10.3892/ol.2017.7026
48) Liu L, Guo K, Liang Z, Li F, Wang H (2018) Identification of candidate genes that may contribute to the metastasis of prostate cancer by bioinformatics analysis. Oncology letters 15 (1):1220-1228. doi:10.3892/ol.2017.7404
49) Dhawan M, Ryan CJ, Ashworth A (2016) DNA Repair Deficiency Is Common in Advanced Prostate Cancer: New Therapeutic Opportunities. The oncologist 21 (8):940-945. doi:10.1634/theoncologist.2016-0135
50) Cheng HH, Pritchard CC, Montgomery B, Lin DW, Nelson PS (2017) Prostate Cancer Screening in a New Era of Genetics. Clinical genitourinary cancer 15 (6):625-628. doi:10.1016/j.clgc.2017.05.024
51) Zhao SG, Chang SL, Spratt DE, Erho N, Yu M, Ashab HA, Alshalalfa M, Speers C, Tomlins SA, Davicioni E, Dicker AP, Carroll PR, Cooperberg MR, Freedland SJ, Karnes RJ, Ross AE, Schaeffer EM, Den RB, Nguyen PL, Feng FY (2016) Development and validation of a 24-gene predictor of response to postoperative radiotherapy in prostate cancer: a matched, retrospective analysis. The Lancet Oncology 17 (11):1612-1620. doi:10.1016/S1470-2045(16)30491-0
52) Shipitsin M, Small C, Choudhury S, Giladi E, Friedlander S, Nardone J, Hussain S, Hurley AD, Ernst C, Huang YE, Chang H, Nifong TP, Rimm DL, Dunyak J, Loda M, Berman DM, Blume-Jensen P (2014) Identification of proteomic biomarkers predicting prostate cancer aggressiveness and lethality despite biopsy-sampling error. British journal of cancer 111 (6):1201-1212. doi:10.1038/bjc.2014.396
53) Lennartz M, Minner S, Brasch S, Wittmann H, Paterna L, Angermeier K, Ozturk E, Shihada R, Ruge M, Kluth M, Koop C, Wilczak W, Krech T, Lebok P, Wittmer C, Heinzer H, Steuber T, Adam M, Huland H, Graefen M, Haese A, Simon R, Sauter G, Schlomm T (2016) The Combination of DNA Ploidy Status and PTEN/6q15 Deletions Provides Strong and Independent Prognostic Information in Prostate Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research 22 (11):2802-2811. doi:10.1158/1078-0432.CCR-15-0635
54) Parimi S, Ko JJ (2017) Recent advances in circulating tumor cells and cell-free DNA in metastatic prostate cancer: a review. Expert review of anticancer therapy 17 (10):939-949. doi:10.1080/14737140.2017.1359544
55) Markou A, Lazaridou M, Paraskevopoulos P, Chen S, Swierczewska M, Budna J, Kuske A, Gorges TM, Joosse SA, Kroneis T, Zabel M, Sedlmayr P, Alix-Panabieres C, Pantel K, Lianidou ES (2017) Multiplex Gene Expression Profiling of In Vivo Isolated Circulating Tumor Cells in High-Risk Prostate Cancer Patients. Clinical chemistry. doi:10.1373/clinchem.2017.275503
56) Djavan B, Nelson K, Kazzazi A, Bruhn A, Sadri H, Gomez-Pinillos A, Ferrari AC (2011) Immunotherapy in the treatment of advanced prostate cancer. The Canadian journal of urology 18 (5):5865-5874
57) Garcia JL, Lozano R, Misiewicz-Krzeminska I, Fernandez-Mateos J, Krzeminski P, Alfonso S, Marcos RA, Garcia R, Gomez-Veiga F, Virseda A, Herrero M, Olmos D, Cruz-Hernandez JJ (2017) A novel capillary nano-immunoassay for assessing androgen receptor splice variant 7 in plasma. Correlation with CD133 antigen expression in circulating tumor cells. A pilot study in prostate cancer patients. Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 19 (11):1350-1357. doi:10.1007/s12094-017-1675-5
58) Seitz AK, Thoene S, Bietenbeck A, Nawroth R, Tauber R, Thalgott M, Schmid S, Secci R, Retz M, Gschwend JE, Ruland J, Winter C, Heck MM (2017) AR-V7 in Peripheral Whole Blood of Patients with Castration-resistant Prostate Cancer: Association with Treatment-specific Outcome Under Abiraterone and Enzalutamide. European urology 72 (5):828-834. doi:10.1016/j.eururo.2017.07.024
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