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  3. Vol. 17 No. 4 (2020): July-August 2020
  4. ORIGINAL PAPER(UROLOGICAL ONCOLOGY)

ISSN: 1735-1308

July-August 2020
Vol. 17 No. 4 (2020)

Role of Chronic Inflammation as a Predictor of Upstaging/Upgrading in Prostate Cancer: Finding a New Group Eligible for Active Surveillance

  • Mohammad Reza Nowroozi
  • Mohsen Ayati
  • Erfan Amini
  • Seyed Majid Aghamiri
  • Seyed Ali Momeni
  • Solmaz Ohadian Moghadam
  • Farzin Valizadeh

Urology Journal, Vol. 17 No. 4 (2020), , Page 370-373
https://doi.org/10.22037/uj.v0i0.5375 Published 23 June 2020

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Abstract

Purpose: We aimed to investigate the correlation between presence of inflammation and pathology upgrading/upstaging in patients with prostate cancer.
Materials and Methods: A retrospective study was accomplished on 315 patients with prostate cancer, eligible for active surveillance except prostate-specific antigen (PSA) level (PSA<30ng/dL), who underwent radical prostatectomy between 2005 and 2015. Patients were divided into two groups based on needle biopsy: A; with evidence of inflammation (chronic prostatitis) and B; without inflammation. The frequency of upstaging and upgrading in both groups was compared in different ranges of PSA level (<10, 10-20 and 20-30ng/dL). Upgrading/Upstaging was defined as increase from one prognostic grade group to another. Statistical analyses were performed to investigate the relation between inflammation and upgrading/upstaging.
Results: The mean age of the patients was 68.2 years and the mean PSA level was 10.2 ng/mL. Chronic prostatitis was identified in 82 of 315 cases therefore upgrading/upstaging were seen in only three patients (3.7%) while 39 of 233 (16.7%) patients without inflammation had upgrading/upstaging in final pathology (P = 0.003). Other variables including the patient's PSA before surgery, PSA density, and the presence of hypoechoic areas in ultrasound had a significant relationship with the incidence of postoperative upgrading/upstaging. Among studied variables, presence of inflammation in biopsies was found to be the most important predictor of upstaging/upgrading (OR: 0.205).
Conclusion: Our data demonstrated that patients with concurrent prostatitis and PCa may have a better prognosis even if the PSA level is higher than 10ng/mL.

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How to Cite

Nowroozi, M. R., Ayati, M., Amini, E., Aghamiri, S. M., Momeni, S. A., Ohadian Moghadam, S., & Valizadeh, F. (2020). Role of Chronic Inflammation as a Predictor of Upstaging/Upgrading in Prostate Cancer: Finding a New Group Eligible for Active Surveillance. Urology Journal, 17(4), 370-373. https://doi.org/10.22037/uj.v0i0.5375
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