Neutrophil-Lymphocyte Ratio Could Be a Marker for Erectile Dysfunction
Urology Journal,
Vol. 16 No. 2 (2019),
5 May 2019
,
Page 216-220
https://doi.org/10.22037/uj.v16i2.5011
Abstract
Purpose: The literature reveals lots of information about the relationship between inflammatory markers and many diseases. In this study, we aimed to determine the relationship between erectile dysfunction and the neutrophil-lymphocyte ratio (NLR), which is a simple and nonspecific inflammatory marker.Materials and Methods: Ninety patients with erectile dysfunction (ED) and ninety-four healthy subjects were included in this study from our internal medicine and urology clinics. As diagnosis criteria, we used the first 5 questions of International Index for Erectile Function. The duration of erectile dysfunction was asked and recorded. Height, weight and waist circumference of patients were measured. We performed total blood count, sedimentation, C-reactive protein, and blood chemistry.
Results: There were statistically significant differences between the control [1,038 (0,507-1,92)] and ED [59,5 (52,0-68,0)] groups in terms of NLR (P < .001). According to the multivariate logistic regression analysis, Duration of ED (Cut off: 7,5 month) predicted ED with 78,8% sensitivity and 63,1% specificity (AUC: < ,001, 95% CI 1,030 (1,010-1,050), P = .003). Moreover, NLR (Cut off: 1,574) predicted ED with 81,8% sensitivity and 67,0% specificity (AUC: < 0,001, 95% CI 1,994 (1,139-3,490), P = .016) according to the multivariate logistic regression analysis.
Conclusion: It was found that the neutrophil-lymphocyte ratio was higher in patient group than the control group. Also, the neutrophil-lymphocyte ratio (NLR) predicted ED and it might be helpful in diagnosing erectile dysfunction.
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References
NIH Consensus Conference. Impotence. NIH Consensus Development Panel on Impotence (1993). Jama 270 (1):83-90
Heaton JP, Adams MA (2004) Causes of erectile dysfunction. Endocrine 23 (2-3):119-123. doi:10.1385/ENDO:23:2-3:119
Selvin E, Burnett AL, Platz EA (2007) Prevalence and risk factors for erectile dysfunction in the US. The American journal of medicine 120 (2):151-157. doi:10.1016/j.amjmed.2006.06.010
Erectile Dysfunction (2016). American family physician 94 (10):Online
Gandaglia G, Briganti A, Jackson G, Kloner RA, Montorsi F, Montorsi P, Vlachopoulos C (2014) A systematic review of the association between erectile dysfunction and cardiovascular disease. European urology 65 (5):968-978. doi:10.1016/j.eururo.2013.08.023
Rosen RC, Cappelleri JC, Gendrano N, 3rd (2002) The International Index of Erectile Function (IIEF): a state-of-the-science review. International journal of impotence research 14 (4):226-244. doi:10.1038/sj.ijir.3900857
Glina S, Cohen DJ, Vieira M (2014) Diagnosis of erectile dysfunction. Current opinion in psychiatry 27 (6):394-399. doi:10.1097/YCO.0000000000000097
Vlachopoulos C, Rokkas K, Ioakeimidis N, Stefanadis C (2007) Inflammation, metabolic syndrome, erectile dysfunction, and coronary artery disease: common links. European urology 52 (6):1590-1600. doi:10.1016/j.eururo.2007.08.004
Goodman DA, Goodman CB, Monk JS (1995) Use of the neutrophil:lymphocyte ratio in the diagnosis of appendicitis. The American surgeon 61 (3):257-259
Guthrie GJ, Charles KA, Roxburgh CS, Horgan PG, McMillan DC, Clarke SJ (2013) The systemic inflammation-based neutrophil-lymphocyte ratio: experience in patients with cancer. Critical reviews in oncology/hematology 88 (1):218-230. doi:10.1016/j.critrevonc. 2013.03.010
Ayta IA, McKinlay JB, Krane RJ (1999) The likely worldwide increase in erectile dysfunction between 1995 and 2025 and some possible policy consequences. BJU international 84 (1):50-56
Feldman HA, Goldstein I, Hatzichristou DG, Krane RJ, McKinlay JB (1994) Impotence and its medical and psychosocial correlates: results of the Massachusetts Male Aging Study. The Journal of urology 151 (1):54-61
Martin-Morales A, Sanchez-Cruz JJ, De Tejada IS, Rodriguez-Vela L, Jimenez-Cruz JF, Burgos-Rodriguez R (2001) Prevalence and independent risk factors for erectile dysfunction in Spain: results of the Epidemiologia de la Disfuncion Erectil Masculina Study. The Journal of urology 166 (2):569-575
Lewis RW, Fugl-Meyer KS, Corona G, Hayes RD, Laumann EO, Moreira ED, Jr., Rellini AH, Segraves T (2010) Definitions/epidemiology/risk factors for sexual dysfunction. The journal of sexual medicine 7 (4 Pt 2):1598-1607. doi:10.1111/j.1743-6109.2010.01778.x
Chew K-K, Bremner A, Stuckey B, Earle C, Jamrozik K (2009) Is the relationship between cigarette smoking and male erectile dysfunction independent of cardiovascular disease? Findings from a population-based cross-sectional study. The journal of sexual medicine 6 (1):222-231
Solomon H, Man JW, Jackson G (2003) Erectile dysfunction and the cardiovascular patient: endothelial dysfunction is the common denominator. Heart 89 (3):251-253
Virag R, Bouilly P, Frydman D (1985) Is impotence an arterial disorder? A study of arterial risk factors in 440 impotent men. Lancet 1 (8422):181-184
Corona G, Giorda CB, Cucinotta D, Guida P, Nada E, SUBITO‐DE Gds (2014) Sexual dysfunction at the onset of type 2 diabetes: the interplay of depression, hormonal and cardiovascular factors. The journal of sexual medicine 11 (8):2065-2073
Fung MM, Bettencourt R, Barrett-Connor E (2004) Heart disease risk factors predict erectile dysfunction 25 years later: the Rancho Bernardo Study. Journal of the American College of Cardiology 43 (8):1405-1411
Feldman HA, Johannes CB, Derby CA, Kleinman KP, Mohr BA, Araujo AB, McKinlay JB (2000) Erectile dysfunction and coronary risk factors: prospective results from the Massachusetts male aging study. Preventive medicine 30 (4):328-338
Montorsi P, Ravagnani PM, Galli S, Salonia A, Briganti A, Werba JP, Montorsi F (2006) Association between erectile dysfunction and coronary artery disease: matching the right target with the right test in the right patient. European urology 50 (4):721-731
Montorsi F, Briganti A, Salonia A, Rigatti P, Margonato A, Macchi A, Galli S, Ravagnani PM, Montorsi P (2003) Erectile dysfunction prevalence, time of onset and association with risk factors in 300 consecutive patients with acute chest pain and angiographically documented coronary artery disease. European urology 44 (3):360-365
Kirby M, Jackson G, Betteridge J, Friedli K (2001) Is erectile dysfunction a marker for cardiovascular disease? International journal of clinical practice 55 (9):614-618
Montorsi P, Ravagnani PM, Galli S, Rotatori F, Veglia F, Briganti A, Salonia A, Deho F, Rigatti P, Montorsi F, Fiorentini C (2006) Association between erectile dysfunction and coronary artery disease. Role of coronary clinical presentation and extent of coronary vessels involvement: the COBRA trial. European heart journal 27 (22):2632-2639. doi:10.1093/eurheartj/ehl142
Vlachopoulos C, Aznaouridis K, Ioakeimidis N, Rokkas K, Vasiliadou C, Alexopoulos N, Stefanadi E, Askitis A, Stefanadis C (2006) Unfavourable endothelial and inflammatory state in erectile dysfunction patients with or without coronary artery disease. European heart journal 27 (22):2640-2648. doi:10.1093/eurheartj/ehl341
Yao F, Huang Y, Zhang Y, Dong Y, Ma H, Deng C, Lin H, Liu D, Lu K (2012) Subclinical endothelial dysfunction and low‐grade inflammation play roles in the development of erectile dysfunction in young men with low risk of coronary heart disease. International journal of andrology 35 (5):653-659
Chiurlia E, D’Amico R, Ratti C, Granata AR, Romagnoli R, Modena MG (2005) Subclinical coronary artery atherosclerosis in patients with erectile dysfunction. Journal of the American College of Cardiology 46 (8):1503-1506
Bocchio M, Desideri G, Scarpelli P, Necozione S, Properzi G, Spartera C, Francavilla F, Ferri C, Francavilla S (2004) Endothelial cell activation in men with erectile dysfunction without cardiovascular risk factors and overt vascular damage. The Journal of urology 171 (4):1601-1604
Araña Rosaínz MdJ, Ojeda MO, Acosta JR, Elías‐Calles LC, González NO, Herrera OT, García Álvarez CT, Rodríguez EM, Báez ME, Seijas EÁ (2011) Imbalanced low‐grade inflammation and endothelial activation in patients with type 2 diabetes mellitus and erectile dysfunction. The journal of sexual medicine 8 (7):2017-2030
Yüksel M, Yıldız A, Oylumlu M, Akyüz A, Aydın M, Kaya H, Acet H, Polat N, Bilik MZ, Alan S (2016) The association between platelet/lymphocyte ratio and coronary artery disease severity. Anatolian journal of cardiology 15 (8):640
Sunbul M, Gerin F, Durmus E, Kivrak T, Sari I, Tigen K, Cincin A (2014) Neutrophil to lymphocyte and platelet to lymphocyte ratio in patients with dipper versus non-dipper hypertension. Clinical and Experimental Hypertension 36 (4):217-221
Azab B, Shah N, Akerman M, McGinn JT (2012) Value of platelet/lymphocyte ratio as a predictor of all-cause mortality after non-ST-elevation myocardial infarction. Journal of thrombosis and thrombolysis 34 (3):326-334
Uthamalingam S, Patvardhan EA, Subramanian S, Ahmed W, Martin W, Daley M, Capodilupo R (2011) Utility of the neutrophil to lymphocyte ratio in predicting long-term outcomes in acute decompensated heart failure. The American journal of cardiology 107 (3):433-438
Tamhane UU, Aneja S, Montgomery D, Rogers E-K, Eagle KA, Gurm HS (2008) Association between admission neutrophil to lymphocyte ratio and outcomes in patients with acute coronary syndrome. The American journal of cardiology 102 (6):653-657
Demirkol S, Balta S, Unlu M, Arslan Z, Cakar M, Kucuk U, Celik T, Arslan E, Turker T, Iyisoy A (2014) Neutrophils/lymphocytes ratio in patients with cardiac syndrome X and its association with carotid intima–media thickness. Clinical and Applied Thrombosis/Hemostasis 20 (3):250-255
Kalay N, Dogdu O, Koc F, Yarlıoglues M, Ardic I, Akpek M, Cicek D, Oguzhan A, Ergin A, Kaya MG (2012) Hematologic parameters and angiographic progression of coronary atherosclerosis. Angiology 63 (3):213-217
Esposito K, Giugliano F, Martedì E, Feola G, Marfella R, D’Armiento M, Giugliano D (2005) High proportions of erectile dysfunction in men with the metabolic syndrome. Diabetes care 28 (5):1201-1203
Giugliano F, Esposito K, Di Palo C, Ciotola M, Giugliano G, Marfella R, D'Armiento M, Giugliano D (2004) Erectile dysfunction associates with endothelial dysfunction and raised proinflammatory cytokine levels in obese men. Journal of endocrinological investigation 27 (7):665-669. doi:10.1007/BF03347500
Eaton C, Liu Y, Mittleman M, Miner M, Glasser D, Rimm E (2007) A retrospective study of the relationship between biomarkers of atherosclerosis and erectile dysfunction in 988 men. International journal of impotence research 19 (2):218
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