The Effects of Diuresis, Duration of Dialysis and Age on Lower Urinary Tract Function in Urologically Healthy Male Patients on the Waiting List for Kidney Transplant
Urology Journal,
Vol. 15 No. 2 (2018),
18 Esfand 2018
,
Page 49-54
https://doi.org/10.22037/uj.v15i2.3888
Abstract
Purpose: This work investigated the effects of diuresis, duration of dialysis and age on lower urinary tract function in urologically healthy males on the waiting list for kidney transplant.Materials and methods: The study included all men who had kidney transplants at our centre between January 2009 and December 2014 who had normal urological findings prior to inclusion on the list. Diuresis, the duration of haemodialysis, age, and parameters of function of the lower urinary tract as determined by filling and voiding cystometry were evaluated.
Results: The study included 127 men (median age, 59 years; median diuresis, 250 mL; median duration of dialysis, 469.5 days). We found that greater diuresis was accompanied by significantly higher FDV, FDV/Cmax, NDV,Cmax and compliance and by significantly lower Pdet.max, PdetQmax and BOOI. Longer duration of dialysis was accompanied by significantly lower FDV, NDV and Cmax, compliance and Qmax.p and with significantly
higher Pdet.max, PdetQmax and BOOI. Older age was associated with significantly higher Pdet.max and with significantly lower compliance. Worsening of the basic parameters of the storage function of the lower urinary tract occurred when diuresis decreased to 500–750 mL, when the duration of dialysis was one year and when patients were older than 54 years.
Conclusion: In healthy male patients on the waiting list for kidney transplant, there were connections between the occurrence of dysfunctions of the lower urinary tract and diuresis, duration of dialysis and age. Patients should be monitored for dysfunctions of the lower urinary tract before and after transplantation.
How to Cite
References
Habib Kashi S., Wynne KS, Sadek SA, et al. An evaluation of vesical urodynamics before renal transplantation and its effect on renal allograft function and survival. Transplantation. 1994;57:1455–1457.
Zermann DH. Disorders of micturition. In: Schrier R, ed. Diseases of the Kidney, 7th ed. Philadelphia: Lippincott-Williams and
Wilkins, 2001: Vol. 1, 663-694.
Barzegar H, Moosazadeh M, Jafari H, Esmaeili, R. Evaluation of dialysis adequacy in hemodialysis patients: A systematic review. Urol J. 2016; 13: 2744-2749.
Tumin M, Satar NHM, Zakaria RZ et al. Determinants of Willingness to Became Organ Donors among Dialysis Patients´ Family Members. Urol J. 2015; 12:2245-2250.
Ounissi M., Gargah T, Bacha MM, et al. Malformative uropathies and kidney transplantation. Transplant Proc. 2011; 43:437-440.
Zhang Y, Wang Y, Zhang P, et al. Extendedrelease doxazosin for treatment of renal transplant recipients with benign prostatic hyperplasia. Transplant Proc. 2009; 41: 3747-3751.
Hurst FP, Neff RR, Falta EM et al. Incidence, predictors, and associated outcomes of prostatism after kidney transplantation. Clin J Am Soc Nephrol. 2009; 4: 329-336.
Tillou X, Lee-Bion A, deLigny BH et al. Does daily urine output really matter in renal transplantation? Ann Transplant. 2013; 18:716-720.
Zermann DH, Loffler U, Reichelt O, Wunderlich H, Wilhelm S, Schubert J. Bladder dysfunction and end stage renal disease. Int Urol Nephrol. 2003; 35: 93-97.
Tsunoyama K, Ishida H, Omoto K, Shimizu T, Shirakawa H, Tanabe K. Bladder function of end-stage renal disease patients. Int Urol Nephrol. 2010; 17: 791-795.
Song M, Park J, Kim YH et al. Bladder capacity in kidney transplant patients with end-stage renal disease. Int Urol Nephrol.
; 47: 101-106.
Chen JL, Lee MC, Kuo HC. Reduction of cystometric bladder capacity and bladder compliance with time in patients with endstage
renal disease. Journal of the Formosan Medical Association. 2012; 111: 209-213.
Martin X, Aboutaieb R, Soliman S, el Essawy A, Dawahra M, Lefrancois N. The use of long-term defunctionalized bladder in renal transplantation: is it safe? Eur Urol. 1999; 36: 450-453.
Ushigome H, Sakai K, Suzuki T et al. Kidney transplantation for patients on long-term hemodialysis. Transplant Proc. 2008; 40:2297-2298.
Dion M, Cristea O, Langford S, Luke PPW, Sener A. Debilitating Lower
Urinary Tract Symptoms in the Post-Renal Transplant Population Can Be Predicted Pretransplantation. Clinical and Translational Research. 2013; 95: 589-594.
Hald T, Horn T. The human urinary bladder in aging. Br. J Urol. 1998; 82, Suppl 1: 59-64.
Homma Y, Imajo C, Takabashi S, Kawabe K, Aso Y. Urinary symptoms and urodynamics in a normal elderly population. Scand J Urol Nephrol Suppl. 1994; 157: 27-30.
Balslev Jorgensen J, Jensen KME, Mogensen P. Longitudinal Observation on Normal and Abnormal Voiding in Men Over the Age of 50 Years. Br J Urol. 1993; 72: 413-420.
Madersbacher S, Pycha A, Schatzl G, Mian C, Klingler CH, Marberger M. The aging lower urinary tract: A comparative urodynamic study of men and women. Adult Urology. 1998; 51:206-212.
Bosch JLHR, Kranse R, van Mastrigt R, Schroeder FH. Dependence of male voiding efficiency on age, bladder contractility and urethral resistence: Development of a voiding efficiency nomogram. J Urol. 1995; 154: 190-194.
Malone-Lee J, Wahedna I. Characterisation of Detrusor Contractile Function in Relation to Old Age. Br J Urol. 1993; 72: 873-880.
Abrams PH. Prostatism and prostatectomy: The value of urine flow rate measurement in the preoperative assessment for operation. J
Urol. 1977; 117: 70-71.
Andersen JT, Jacobsen O, Worm-Petersen J et al. Bladder function in healthy elderly males. Scand J Urol Nephrol. 1978; 12:123-127.
Drach GW, Layton TN, Binard WJ. Male peak urinary flow rate: relationships to volume and age. J Urol. 1979; 122: 210-214.
Gammelgaard J. Micturition patterns in normal adults. Ugeskr Laeger. 1974;48: 2675-2678.
Ball AJ, Feneley RCL, Abrams PH. The natural history of untreated prostatism. Br J Urol. 1981. 53:613-616.
- Abstract Viewed: 978 times
- PDF Downloaded: 392 times