Comparison of Loratadine and Cetirizine in Perennial Allergic Rhinitis
Novelty in Biomedicine,
Vol. 3 No. 3 (2015),
AbstractBackground: Allergic rhinitis (AR) represents a global health problem, affecting 5-50% of the population worldwide and numerous classes of pharmacological agents are available for its treatment. Two more popular of these drugs are Loratadine and Cetirizine. There are few direct comparator studies between these two drugs with inconsistent results.
Materials and Methods: A randomized, double-blind study for comparison the therapeutic effects of Loratadine and Cetirizine was conducted in an otolaryngologic clinic of a general hospital. Eighty patients with perennial allergic rhinitis were divided into two equal groups. One group received Loratadine 10 mg daily for two weeks and the other group Cetirizine 10 mg daily also for two weeks. Alterations of the allergic rhinitis symptoms including rhinorrhea, sneezing, nasal itching and nasal obstruction were compared between the two groups.
Results: Severity of all four studied symptoms was reduced by both drugs. Although Cetirizine had a little more efficacy, their difference was not statistically significant (P>0.05). These two medications were most effective in reducing the sneezing and least effective on the nasal obstruction.
Conclusion: Loratadine and Cetirizine can reduce symptoms of the perennialallergic rhinitis but their difference is not statistically significant.
- Allergic Rhinitis
How to Cite
Sibbald B, Rink E. Epidemiology of seasonal and perennial rhinitis: clinical presentation and medical history. Thorax. 1991;46:895-901.
Meltzer EO. The prevalence and medical and economic impact of allergic rhinitis in the United States.J Allergy ClinImmunol. 1997;99(6, pt 2): 805-28.
Wright AL, Holberg CJ, Martinez FD, Halonen M, Morgan W, Taussig LM. Epidemiology of physician-diagnosed allergic rhinitis in childhood. Pediatrics. 1994;94(6, pt 1):895-901.
Bousquet J. Allergic Rhinitis and its Impact on Asthma (ARIA). ClinExp All Rev 2003:3:43–5.
Lehman Jm, Blaiss MS. Selecting the optimal oral antihistamine for patients with allergic rhinitis. Drugs. 2006;66(18):2309-19.
Zheng M, Wang X, Bo M, Wang K, Zhao Y, He F, et al. Prevalence of allergic rhinitis among adults in urban and rural areas of china: a population-based cross-sectional survey. Allergy Asthma Immunol Res. 2015;7(2):148-57.
Bousquet J, van Cauwenberge P, Khaltaev N, ARIA Workshop Group, World Health Organization. Allergic rhinitis and its impact on asthma. JAllergy ClinImmunol. 2001;108(5, suppl):S147-S334.
Xiao J, Wu WX, Ye YY, Lin WJ, Wang L. A network meta-analysis of randomized controlled trials focusing on different allergic rhinitis medications. Am J Ther. 2015 Apr 9. [Epub ahead of print]
Lockey RF, Widlitz MD, Mitchell DQ, Lumry W, Dockhorn R, Woehler T, et al. Comparative study of cetirizine and terfenadine versus placebo in the symptomatic management of seasonal allergic rhinitis. Ann Allergy Asthma Immunol. 1996;76:448-54.
Falliers CJ, Brandon ML, Buchman E, Connell JT, Dockhorn R, Leese PT, et al. Double-blind comparison of cetirizine and placebo in the treatment of seasonal rhinitis.Ann Allergy. 1991;66:257-62.
Dockhorn RJ, Bergner A, Connell JT, Falliers CJ, Grabiec SV, Weiler JM, et al. Safety and efficacy of loratadine (Sch-29851): a new non-sedating antihistamine in seasonal allergic rhinitis. Ann Allergy. 1987;58:407-11.
Skassa-Brociek W, Bousquet J, Montes F, Verdier M, Schwab D, Lherminier M, et al. Double-blind placebo controlled study of loratadine, mequitazine, and placebo in the symptomatic treatment of seasonal allergic rhinitis. J Allergy ClinImmunol. 1988;81:725-30.
Simons FE. Advances in H1-antihistamines. N Engl J Med. 2004;351(21):2203-17.
Noonan MJ, Raphael GD, Nayek A, Greos L, Olufade AO, Leidy NK, et al. The health-related quality of life effects of once-daily cetirizine HCl in patients with seasonal allergic rhinitis: a randomized double-blind, placebo-controlled trial. Clin Exp Allergy. 2003;33(3):351-8.
Chiang YC, Shyur SD, Chen TL, Huang LH, Wen TC, Lin MT, et al. A randomized controlled trial of cetirizine plus pseudoephedrine versus loratadine plus pseudoephedrine for perennial allergic rhinitis. Asian Pac J Allergy Immunol. 2006;24(2-3):97-103.
Nunes C, Ladeira S. Double-blind study of cetirizine and loratadine versus placebo in patients with allergic rhinitis. J Investig Allergol Clin Immunol. 2000;10:20-23.
Greisner WA 3rd. Onset of action for the relief of allergic rhinitis symptoms with second-generation antihistamines. Allergy Asthma Proc. 2004;25(2):81-3.
Salmun LM, Gates D, Scharf M, Greiding L, Ramon F, Heith off K. Loratadine versus cetirizine: assessment of somnolence and motivation during the workday. Clin Ther. 2000;22(5):573-82.
Slater JW, Zechnich AD, Haxby DG. Second-generation antihistamines: a comparative review. Drugs. 1999;57(1):31-47.
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