Investigation of the Frequency and Types of Errors During the Preparation and Injection of Chemotherapy Drugs
Novelty in Biomedicine,
Vol. 13 No. 4 (2025),
28 October 2025
,
Page 222-227
https://doi.org/10.22037/nbm.v13i4.49580
Abstract
Background: Medical errors are common in the world, but in some wards and some conditions, they need a higher level of concern. Chemotherapy and its related wards are one of the concerning issues. There are limited studies about the occurrence of medical errors in patients who receive chemotherapy. In this study, we aimed to investigate the frequency and types of errors during the preparation and injection of chemotherapy drugs.
Materials and Methods: This cross-sectional study was conducted on patients who were referred to the outpatient chemotherapy department of Imam Hossein Hospital (Tehran, Iran) in 2024. Basic patient data, including age, gender, type of cancer, presence or absence of other underlying diseases, and type of chemotherapy regimen, were extracted. All medication orders during chemotherapy prescribed by the subspecialist physician were reviewed and recorded by the internal medicine specialist assistant under the supervision of the project's supervisory team (clinical specialist, subspecialist, and clinical pharmacy); errors related to the medication process and related to chemotherapy medication errors were identified according to the researcher-made checklist. A statistical significance level was considered less than 0.05.
Results: Three hundred patients were evaluated. Medical errors were observed in 247 (82.33%) patients. Medical errors were significantly higher in patients with metastatic cancers than in patients with non-metastatic cancers (P-value: 0.002). No hand washes the most common type of medical error (39.27%), and the most common cause was job burnout (33.60) was the most common cause of medical errors.
Conclusion: Medical error frequency during the preparation and injection of chemotherapy drugs in outpatient wards is 82.33%.
- Cancer
- Medication error
- Chemotherapy
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References
1. Camerini FG, Silva LDd. Patient safety: analysing intravenous medication preparation in a sentinel network hospital in Brazil. Texto & Contexto-Enfermagem. 2011;20:41-9.
2. Mendes JR, Lopes MCBT, Vancini-Campanharo CR, Okuno MFP, Batista REA. Types and frequency of errors in the preparation and administration of drugs. Einstein (São Paulo). 2018;16:eAO4146.
3. Mattsson T, Holm B, Michelsen H, Knudsen J, Brixen K, Herrstedt J. Non-intercepted dose errors in prescribing anti-neoplastic treatment: a prospective, comparative cohort study. Annals of Oncology. 2015;26(5):981-6.
4. Weiss BD, Scott M, Demmel K, Kotagal UR, Perentesis JP, Walsh KE. Significant and sustained reduction in chemotherapy errors through improvement science. Journal of Oncology Practice. 2017;13(4):e329-e36.
5. Bergamini A, Pisano C, Di Napoli M, et al. Cisplatin can be safely administered to ovarian cancer patients with hypersensitivity to carboplatin. Gynecologic oncology. 2017;144(1):72-6.
6. Pham JC, Story JL, Hicks RW, et al. National study on the frequency, types, causes, and consequences of voluntarily reported emergency department medication errors. The Journal of emergency medicine. 2011;40(5):485-92.
7. Kuo GM, Touchette DR, Marinac JS, Collaborative ACoCPPBRN. Drug Errors and Related Interventions Reported by U nited S tates Clinical Pharmacists: The A merican C ollege of C linical P harmacy P ractice‐B ased R esearch N etwork M edication E rror D etection, A melioration and P revention Study. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy. 2013;33(3):253-65.
8. Bruce K, Hall L, Castelo S, Evans M, Frangoul H. Direct provider feedback to decrease chemotherapy ordering errors: The "gray envelope" initiative. Pediatric Blood & Cancer. 2012;59(7):1330-1.
9. Aradhya PJ, Ravi R, Chandra BJS, Ramesh M, Chalasani SH. Assessment of medication safety incidents associated with high-alert medication use in intensive care setting: a clinical pharmacist approach. Indian Journal of Critical Care Medicine: Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine. 2023;27(12):917.
10. Cajanding JMR. Administering and monitoring high-alert medications in acute care. Nursing Standard. 2017;31(47).
11. Kahangi LS, Chaharsoughi NT. Chemotherapy medication errors in patients with cancer: A narrative review. Journal of Multidisciplinary Care. 2021;10(3):126-31.
12. Dorothy A, Yadesa TM, Atukunda E. Prevalence of medication errors and the associated factors: a prospective observational study among cancer patients at Mbarara regional referral hospital. Cancer Management and Research. 2021:3739-48.
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