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  3. Vol. 13 No. 2 (2025): Vol. 13 No. 2 (2025): Spring2025
  4. Original Article

Vol. 13 No. 2 (2025)

Farvardin 2025

Evaluation of the role of susceptibility-weighted imaging (SWI) as a new complementary sequence in routine brain MRI

  • Maryam Haghighi-Morad
  • Maryam Sadeghi

Novelty in Biomedicine, Vol. 13 No. 2 (2025), 19 Farvardin 2025 , Page 67-74
https://doi.org/10.22037/nbm.v13i2.45581 Published: 2025-04-19

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Abstract

Background: Susceptibility-weighted imaging (SWI), an advanced MRI technique, has a high sensitivity in detecting microvascular changes, hemorrhages, and calcifications, thereby improving the diagnosis and management of various neurological pathologies. This study evaluated the frequency of abnormal findings in SWI sequence in patients with brain pathologies referred to Loghman Hakim Hospital.

Materials and Methods: This cross-sectional study was conducted on patients with various brain pathologies who underwent brain MRI with SWI sequence at Loghman Hakim Hospital from October 2021 to October 2022. The frequency of different brain pathologies in the SWI sequence was assessed.

Results: A total of 157 brain pathologies were evaluated. In 129 cases (82.2%), the most probable lesion diagnosis was only found in the SWI sequence. Thrombosis in veins was found in all cerebral venous thrombosis (CVT) patients in SWI and other sequences. Hemorrhage in venous infarct was observed in 20% of CVT cases. In patients with vascular malformations, the diagnosis of cavernoma was made in 9 patients (81.8%) and capillary telangiectasia in 2 patients (18.2%).

Conclusion: The findings of this study demonstrated the significant role of SWI in evaluating various brain pathologies, especially in cases where routine MRI sequences are not diagnostic. Therefore, we recommend using SWI in routine brain MRI.

Keywords:
  • Brain
  • Magnetic resonance imaging
  • Pathology
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How to Cite

Haghighi-Morad, M., & Sadeghi, M. (2025). Evaluation of the role of susceptibility-weighted imaging (SWI) as a new complementary sequence in routine brain MRI. Novelty in Biomedicine, 13(2), 67–74. https://doi.org/10.22037/nbm.v13i2.45581
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References

Di Ieva A, Lam T, Alcaide-Leon P, Bharatha A, Montanera W, Cusimano MD. Magnetic resonance susceptibility weighted imaging in neurosurgery: current applications and future perspectives. Journal of neurosurgery. 2015;123(6):1463-75.

Ashwal S, Wycliffe ND, Holshouser BA. Advanced neuroimaging in children with nonaccidental trauma. Developmental neuroscience. 2011;32(5-6):343-60.

Bian W, Hess CP, Chang SM, Nelson SJ, Lupo JM. Susceptibility-weighted MR imaging of radiation therapy-induced cerebral microbleeds in patients with glioma: a comparison between 3T and 7T. Neuroradiology. 2014;56:91-6.

Di Ieva A, Matula C, Grizzi F, Grabner G, Trattnig S, Tschabitscher M. Fractal analysis of the susceptibility weighted imaging patterns in malignant brain tumors during antiangiogenic treatment: technical report on four cases serially imaged by 7 T magnetic resonance during a period of four weeks. World Neurosurgery. 2012;77(5-6):785. e11-. e21.

Di Ieva A, Tschabitscher M, Galzio RJ, Grabner G, Kronnerwetter C, Widhalm G, et al. The veins of the nucleus dentatus: anatomical and radiological findings. Neuroimage. 2011;54(1):74-9.

Li C, Ai B, Li Y, Qi H, Wu L. Susceptibility-weighted imaging in grading brain astrocytomas. European Journal of Radiology. 2010;75(1):e81-e5.

Colbert CA, Holshouser BA, Aaen GS, Sheridan C, Oyoyo U, Kido D, Ashwal S. Value of cerebral microhemorrhages detected with susceptibility-weighted MR Imaging for prediction of long-term outcome in children with nonaccidental trauma. Radiology. 2010;256(3):898-905.

Grabner G, Nöbauer I, Elandt K, Kronnerwetter C, Woehrer A, Marosi C, et al. Longitudinal brain imaging of five malignant glioma patients treated with bevacizumab using susceptibility-weighted magnetic resonance imaging at 7 T. Magnetic resonance imaging. 2012;30(1):139-47.

Zeng Q-S, Kang X-S, Li C-F, Zhou G-Y. Detection of hemorrhagic hypointense foci in radiation injury region using susceptibility-weighted imaging. Acta radiologica. 2011;52(1):115-9.

Hemeda YH. Positive Susceptibility Vessel Sign on SWI-MRI Sequence Imaging Might Differentiate Patients Had Silent Brain Ischemia among Apparently Neurologically-Free Patients. The Egyptian Journal of Hospital Medicine. 2022;86(1):437-46.

Haller S, Haacke EM, Thurnher MM, Barkhof F. Susceptibility-weighted imaging: technical essentials and clinical neurologic applications. Radiology. 2021;299(1):3-26.

Abu-samra MF, Amin MF, Yassen AM, Fath El-Bab AK, Gabr MF. SWI as a promising tool comparable to CT perfusion in evaluation of acute cerebral infarction. Egyptian Journal of Radiology and Nuclear Medicine. 2021;52:1-10.

Löbel U, Sedlacik J, Sabin ND, Kocak M, Broniscer A, Hillenbrand CM, Patay Z. Three-dimensional susceptibility-weighted imaging and two-dimensional T2*-weighted gradient-echo imaging of intratumoral hemorrhages in pediatric diffuse intrinsic pontine glioma. Neuroradiology. 2010;52:1167-77.

Toth A, Kovacs N, Perlaki G, Orsi G, Aradi M, Komaromy H, et al. Multi-modal magnetic resonance imaging in the acute and sub-acute phase of mild traumatic brain injury: can we see the difference? Journal of neurotrauma. 2013;30(1):2-10.

El-Koussy M, Schroth G, Gralla J, Brekenfeld C, Andres R, Jung S, et al. Susceptibility-weighted MR imaging for diagnosis of capillary telangiectasia of the brain. American journal of neuroradiology. 2012;33(4):715-20.

Deistung A, Schweser F, Wiestler B, Abello M, Roethke M, Sahm F, et al. Quantitative susceptibility mapping differentiates between blood depositions and calcifications in patients with glioblastoma. PloS one. 2013;8(3):e57924.

Deistung A, Schäfer A, Schweser F, Biedermann U, Güllmar D, Trampel R, et al. High-resolution MR imaging of the human brainstem in vivo at 7 Tesla. Frontiers in human neuroscience. 2013;7:710.

Hunter JV, Wilde EA, Tong KA, Holshouser BA. Emerging imaging tools for use with traumatic brain injury research. Journal of neurotrauma. 2012;29(4):654-71.

Wang M, Dai Y, Han Y, Haacke EM, Dai J, Shi D. Susceptibility weighted imaging in detecting hemorrhage in acute cervical spinal cord injury. Magnetic resonance imaging. 2011;29(3):365-73.

Spronk E, Sykes G, Falcione S, Munsterman D, Joy T, Kamtchum-Tatuene J, Jickling GC. Hemorrhagic Transformation in Ischemic Stroke and the Role of Inflammation. Frontiers in neurology. 2021;12:661955.

Rubin A, Waszczuk Ł, Trybek G, Kapetanakis S, Bladowska J. Application of susceptibility weighted imaging (SWI) in diagnostic imaging of brain pathologies–a practical approach. Clinical Neurology and Neurosurgery. 2022;221:107368.

Rashid AMA, Yaakob MNM, Kamis MFA-K, Noh MSFM. The prominent hypointense vessel sign on susceptibility-weighted imaging (SWI) as a potential imaging biomarker for poor clinical outcome in acute ischemic stroke (AIS). Radiology Case Reports. 2022;17(11):4268-71.

Mohammed W, Xunning H, Haibin S, Jingzhi M. Clinical applications of susceptibility-weighted imaging in detecting and grading intracranial gliomas: a review. Cancer imaging : the official publication of the International Cancer Imaging Society. 2013;13(2):186-95.

Löbel U, Sedlacik J, Sabin ND, Kocak M, Broniscer A, Hillenbrand CM, Patay Z. Three-dimensional susceptibility-weighted imaging and two-dimensional T2*-weighted gradient-echo imaging of intratumoral hemorrhages in pediatric diffuse intrinsic pontine glioma. Neuroradiology. 2010;52(12):1167-77.

Ceballos-Ceballos J, Loza-Gallardo DA, Barajas-Romero MA, Cantú-Brito C, Valdés-Ferrer SI. Recognition of Brain Metastases Using Gadolinium-Enhanced SWI MRI: Proof-of-Concept Study. Frontiers in neurology. 2020;11:5.

Halefoglu AM, Yousem DM. Susceptibility weighted imaging: Clinical applications and future directions. World journal of radiology. 2018;10(4):30-45.

Al-Zandi SH, Fayadh NA, Al-Waely NK. Central vein sign detected by SWI at 3 T MRI as a discriminator between multiple sclerosis and leukoaraiosis. The Egyptian Journal of Radiology and Nuclear Medicine. 2018;49(1):158-64.

Conklin J, Frosch MP, Mukerji SS, Rapalino O, Maher MD, Schaefer PW, et al. Susceptibility-weighted imaging reveals cerebral microvascular injury in severe COVID-19. Journal of the neurological sciences. 2021;421:117308.

Toh CH, Wei KC, Chang CN, Hsu PW, Wong HF, Ng SH, et al. Differentiation of pyogenic brain abscesses from necrotic glioblastomas with use of susceptibility-weighted imaging. AJNR American journal of neuroradiology. 2012;33(8):1534-8.

Boukerche F, Balakrishnan S, Kalapos P, Thamburaj K. Detection of cerebral cortical vein thrombosis with high-resolution susceptibility weighted imaging- A comparison with MR venography and standard MR sequences. Neuroradiology. 2023;65(5):885-92.

Sadik JC, Jianu DC, Sadik R, Purcell Y, Novaes N, Saragoussi E, et al. Imaging of Cerebral Venous Thrombosis. Life (Basel, Switzerland). 2022;12(8).

Kashyap PV, Kashyap M, Dhiran A, Yadav A. Missed Cerebral Venous Thrombosis: A Diagnostic Challenge. Annals of Neurosciences. 2023;30(3):197-204.

Chaudhry US, De Bruin DE, Policeni BA. Susceptibility-weighted MR imaging: a better technique in the detection of capillary telangiectasia compared with T2* gradient-echo. AJNR American journal of neuroradiology. 2014;35(12):2302-5.

El-Koussy M, Schroth G, Gralla J, Brekenfeld C, Andres RH, Jung S, et al. Susceptibility-weighted MR imaging for diagnosis of capillary telangiectasia of the brain. AJNR American journal of neuroradiology. 2012;33(4):715-20.

Sparacia G, Speciale C, Banco A, Bencivinni F, Midiri M. Accuracy of SWI sequences compared to T2*-weighted gradient echo sequences in the detection of cerebral cavernous malformations in the familial form. The Neuroradiology Journal. 2016;29(5):326-35.

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