Effects of Henna-Violet Based Topical Preparation in Preventing and Reducing the Severity of Radiation-Induced Dermatitis in Breast Cancer Patients: A Randomized, Double-Blind Clinical Trial
Novelty in Biomedicine,
Vol. 10 No. 4 (2022),
Background: Radiation-induced dermatitis (RID) is a common side effect of radiotherapy. The present work
attempts to examine the effect of using henna- violet based topical preparation to prevent and decrease the
severity of RID in patients with breast cancer.
Materials and Methods: The study was carried out as a prospective, double-blind clinical study on 43 breast
cancer patients aged 18-75 years. The subjects had undergone breast-conserving surgery, and radiotherapy was scheduled for them. The participants were categorized randomly into two groups; patients who received the henna- violet based topical preparation and patients who received a placebo twice a day for six weeks. The level of the RID score was measured every week based on the toxicity criteria of the radiation therapy oncology group (RTOG).
Results: The henna- violet based topical preparation decreased the severity of RID and delayed the
development of grade 2 RID for two weeks. In addition, the initiation of grade 3 RID was deferred for one
week. There was a significant decrease in grade 2 RID (20% vs. 56.52%) as well as grade 3 RID (10% vs.
26.09%) in the patients who received the henna- violet based topical preparation at the end of the 6th week
Conclusion: This cream, which contained henna and violet, had no severe adverse effects, could prevent RID
and decreased the grade of dermatitis in breast cancer patients compared to the placebo.
- Breast Cancer, Dermatitis, Radiotherapy, Prevention, Lawsonia inermis L, Viola odorata
How to Cite
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