A Potential Role of Cytomegalovirus Reactivation in the Severity of COVID-19 in the Elderly
Novelty in Biomedicine,
Vol. 10 No. 2 (2022),
In late 2019, severe acute respiratory syndrome- coronavirus-2 (SARS-CoV-2) was reported in Wuhan, China. This virus spread quickly worldwide, with millions of victims until now. The clinical manifestations of the novel coronavirus disease (COVID-19) are a broad spectrum, from asymptomatic and mild cases with a flu-like syndrome to severe cases requiring intensive care1.
The severity of diseases and risk of mortality is higher in the elderly, which most authorities attribute to underlying conditions, including diabetes, hypertension, cardiovascular diseases, and respiratory diseases. However, some neglected factors, such as cytomegalovirus (CMV) reactivation, can affect patient outcomes2.
- COVID-19, Cytomegalovirus, Opportunistic infections, Prognosis, SARS-CoV-2
How to Cite
Söderberg-Nauclér C. Does reactivation of cytomegalovirus contribute to severe COVID-19 disease? Immunity & ageing : I & A. Mar 12 2021;18(1):12.
Kadambari S, Klenerman P, Pollard AJ. Why the elderly appear to be more severely affected by COVID-19: The potential role of immunosenescence and CMV. Reviews in medical virology. Sep 2020;30(5):e2144.
Niitsu T, Shiroyama T, Hirata H, et al. Cytomegalovirus infection in critically ill patients with COVID-19. The Journal of infection. Oct 2021;83(4):496-522.
Müller L, Di Benedetto S. How Immunosenescence and Inflammaging May Contribute to Hyperinflammatory Syndrome in COVID-19. International journal of molecular sciences. Nov 21 2021;22(22).
Vigón L, García-Pérez J, Rodríguez-Mora S, et al. Impaired Antibody-Dependent Cellular Cytotoxicity in a Spanish Cohort of Patients With COVID-19 Admitted to the ICU. Frontiers in immunology. 2021;12:742631.
Yamamoto Y, Shiroyama T, Hirata H, et al. Prolonged corticosteroid therapy and cytomegalovirus infection in patients with severe COVID-19. Journal of medical virology. Oct 28 2021.
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