Evaluation of Neurofibromatosis Gene Expression in Non-Hereditary Breast Cancer
Novelty in Biomedicine,
Vol. 11 No. 1 (2023),
20 March 2023
Background: Breast cancer is the most common cause of death in women. Studies have shown that changes in neurofibromatosis gene expression can cause breast cancer. The aim of this study was to investigate the change of neurofibromatosis type 1 gene expression in non-hereditary breast cancer using real time PCR.
Materials and Methods: In this study, 160 tissue samples were collected from patients following ethical principles. After lysis of tissues, extraction of RNA and synthesis of cDNA was performed. The amount of gene expression changes was investigated.
Results: The results showed that the level of NF1 gene expression was dependent on the stages of the disease and as the stages progress, the level of expression of this gene showed a significant decrease.
Conclusion: The use of gene biomarkers can help to diagnose and treat diseases faster. Along with examining other candidate genes, using NF1 gene expression analysis in breast cancer patients can be a suitable option for diagnosing the stages of disease progression.
- Breast cancer, Gene expression, Neurofibromatosis gene
How to Cite
Moodi M, Rezaeian M, Mostafavi F, Sharifirad GR 2013. The study of mammography screening behavior based on stage of change model in isfahanian women of age 40 and older: a population-based study. J Adv Med Biomed Res. 21(84): 24-35.
Akbari ME, Sayad S, Saed S, Khayamzadeh M, Shojaee L, Shormeji Z, et al. Breast Cancer Status in Iran: Statistical Analysis of 3010 Cases between 1998 and 2014. Int J of Breast Cancer; Article ID 2481021. 2017;10.
Harirchi I, Kolahdoozan S, Karbakhsh M, Chegini N, Mohseni SM, Montazeri A, et al. Twenty years of breast cancer in Iran: downstaging without a formal screening program. Ann Oncol. 2011;22(1):93-7.
Akbari ME, Mirzaei HR. Opening Speech. Abstract book of nine the International Breast Cancer Congress. First ed. Tehran: Resaneh Takhasosi Pub. 2014;40-6.
Fonsecasanchez MA, Rodriguezcuevas S, Mendozahernandez G, Bautistapina V, Arechaga Ocampo E, et al. Breast cancer proteomics reveals a positive correlation between glyoxalase 1 expression and high tumor grade. Int J Oncol. 2012;41:670-80.
Skirmante S, Sirvaitis R, Perusek T, Garcia-Zuazaga J. Early Cutaneous Signs of Neurofibromatosis Type 1. Journal of the Dermatology Nurses' Association. 2017;9(4 ):191-3.
Korf, BR. Neurofibromatosis type 1 (NF1): Pathogenesis, clinical features, and diagnosis.; Management and prognosis. In: T. W. Post (Ed.), Up-to-date. Waltham, MA: Up-to-date. Retrieved from www.uptodate.com; 2017.
Dursun D, Aktaş S, Altun Z, Olgun N. Bilateral Breast Cancer with Neurofibromatosis Type 1 Patient: Case Report. Eur J Breast Health. 2017;13(4):213-5.
Helfferich J, Nijmeijer R, Oebele FB, Boon M, Fock A, Hoving EW, et al. Neurofibromatosis type 1 associated low grade gliomas: A comparison with sporadic low grade gliomas. Critical Reviews in Oncology/Hematology. 2016;104:30- 41.
Hassan KM. Neurofibromatosis presenting with a large mass overlying the sacrum a case from the archive of a retired orthopedic surgeon. Basrah Journal of Surgery. 2018;24(1):74-6.
Lee JW, Jeong EG, Soung YH, Nam SW, Lee JY, Yoo NJ, et al. Decreased expression of tumour suppressor Bax-interacting factor-1 a Bax activator in gastric carcinomas. Pathology. 2013;38:312-5.
Ci W, Polo JM, Cerchietti L, Shaknovich R, Wang L, Yang SN, et al. The BCL6 transcriptional program features repression of multiple oncogenes in primary B cells and is deregulated in DLBCL. Blood. 2009;113(22):5536-48.
Brosseau JP, Chung-Ping L, Yong W, Vijay R, Vandergriff T, Lee M, et al. NF1 heterozygosity fosters de novo tumorigenesis but impairs malignant transformation. Nature Communications. 9 Article number. 2014;5014.
Hadziak L, Goldhirsch A, Wood WC, Coates AS, Gelber RD, Thurlimann B, et al. Strategies for subtypes- dealing with the diversity of breast cancer; high of the St. Gallen Informational Expert Consensus on the Primary Therapy of Early Breast Cancer. Ann Oncol. 2011;1736-47.
Pan D, Liang P, Xiao H. Neurofibromatosis type 1 associated with pheochromocytoma and gastrointestinal stromal tumors: A case report and literature review. Oncol Lett. 2016;12(1):637-43.
Glenmore Lasam G, Marcelina L. High Grade Atrioventricular Block in Von Recklinghausen Disease: A Rare Phenomenon. Cardiol Res. 2018;9(3):176–9.
Gutmann DH, Michael D , Lellan Mc, Hussain I, Wallis JW, Lucinda L, et al. Somatic neurofibromatosis type 1 (NF1) inactivation characterizes NF1-associated pilocytic astrocytoma. Genome Res. 2013;23:431-9.
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